INT60174

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 1.05
Pain Relevance 3.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell cycle (Pik3c3) cell division (Pik3c3) kinase activity (Pik3c3)
Anatomy Link Frequency
neurons 3
brain 1
hippocampus 1
Pik3c3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 20 99.98 Very High Very High Very High
Hippocampus 31 99.80 Very High Very High Very High
nMDA receptor 96 99.38 Very High Very High Very High
bradykinin 3 99.36 Very High Very High Very High
adenocard 4 99.06 Very High Very High Very High
cytokine 5 98.88 Very High Very High Very High
opioid receptor 5 98.48 Very High Very High Very High
Sumatriptan 2 86.20 High High
Serotonin 3 75.00 Quite High
long-term potentiation 51 62.80 Quite High
Disease Link Frequency Relevance Heat
Holoprosencephaly 1 100.00 Very High Very High Very High
Apoptosis 48 98.72 Very High Very High Very High
Cancer 94 91.76 High High
Targeted Disruption 20 85.64 High High
Death 10 82.48 Quite High
Toxicity 3 74.36 Quite High
Syndrome 1 72.04 Quite High
Parkinson's Disease 116 70.36 Quite High
Insulin Resistance 24 53.04 Quite High
Impaired Glucose Tolerance 9 44.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibition of morphine-induced increase in PKCgamma phosphorylation reduced Vps34 level.
Positive_regulation (increase) of Vps34 associated with morphine
1) Confidence 0.67 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.40
In this study, we investigated whether PKCgamma could be associated with functional changes of vacuolar protein sorting 34 (Vps34) during morphine treatment using primary cultures of cerebral cortical neurons from mice.
Positive_regulation (changes) of Vps34 in neurons associated with morphine
2) Confidence 0.48 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.36
Phosphorylation of PKCgamma increased Vps34 level.
Positive_regulation (increased) of Vps34
3) Confidence 0.48 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.40
The treatment with morphine increases PKCgamma and Vps34 levels.
Positive_regulation (increases) of Vps34 associated with morphine
4) Confidence 0.45 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.40
These results indicates that opioid receptor activation increases PKCgamma phosphorylation in the neurons and, in turn, upregulates Vps34 during short-term treatment with neurons.
Positive_regulation (upregulates) of Vps34 in neurons associated with opioid receptor
5) Confidence 0.42 Published 2009 Journal Synapse Section Abstract Doc Link 19173263 Disease Relevance 0 Pain Relevance 0.38
It is proposed that tyrosine kinases are activated during IP through some ill-defined interaction with G-protein coupled receptors such as the adenosine and bradykinin receptors and that this causes activation of phosphatidyl inositol 3 phosphate kinase (PI-3-kinase).
Positive_regulation (activation) of PI-3-kinase associated with adenocard and bradykinin
6) Confidence 0.04 Published 2007 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2212780 Disease Relevance 0.07 Pain Relevance 0.10
The 5-HT5A gene colocalized with the mouse mutation reeler and the human mutation holoprosencephaly type 3, which both result in abnormal brain development, raising the possibility that the 5-HT5A receptor plays a role in brain development.
Positive_regulation (result) of holoprosencephaly type 3 in brain associated with holoprosencephaly
7) Confidence 0.04 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8450829 Disease Relevance 0.10 Pain Relevance 0.28
We also detected a 20% increase in IRS-1┬ľassociated PI3-kinase activity (Fig. 3D) of Tg IRS-1 Ser?
Positive_regulation (increase) of PI3-kinase
8) Confidence 0.02 Published 2008 Journal Diabetes Section Body Doc Link PMC2551673 Disease Relevance 0.05 Pain Relevance 0
Leptin receptors are class I cytokine receptors (Tartaglia et al., 1995) associated with the activation of PI 3-kinase and MAPK signaling cascades in neurons (Harvey, 2003; Irving et al., 2006).
Positive_regulation (activation) of PI 3-kinase in neurons associated with cytokine
9) Confidence 0.02 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.31
Our previous studies have shown that leptin facilitates hippocampal NMDA receptor function via a combination of PI 3-kinase and MAPK activation (Shanley et al., 2001).
Positive_regulation (activation) of PI 3-kinase associated with nmda receptor
10) Confidence 0.02 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.35
Indeed, the ability of leptin to facilitate NMDA receptor function in the hippocampus involves activation of PI 3-kinase and MAPK-dependent processes (Shanley et al., 2001).
Positive_regulation (activation) of PI 3-kinase in hippocampus associated with nmda receptor and hippocampus
11) Confidence 0.02 Published 2007 Journal Mol Cell Neurosci Section Body Doc Link PMC1995039 Disease Relevance 0 Pain Relevance 0.25
Recently, it was shown that Apoptin-induced apoptosis essentially depends on abnormal phosphatidylinositol 3-kinase (PI3-kinase)/Akt activation, resulting in the activation of the cyclin-dependent kinase CDK2 [32].
Positive_regulation (activation) of PI3-kinase associated with apoptosis
12) Confidence 0.01 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 0.83 Pain Relevance 0

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