INT6018

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Context Info
Confidence 0.60
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.36
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMB9) nucleoplasm (PSMB9) peptidase activity (PSMB9)
small molecule metabolic process (PSMB9) nucleus (PSMB9) cellular nitrogen compound metabolic process (PSMB9)
Anatomy Link Frequency
brain 1
uterine 1
fat cells 1
PSMB9 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 6 98.74 Very High Very High Very High
Central nervous system 28 97.76 Very High Very High Very High
Potency 1 90.44 High High
Clonidine 2 88.68 High High
tolerance 6 87.00 High High
agonist 7 86.80 High High
noradrenaline 2 83.64 Quite High
positron emission tomography 3 80.04 Quite High
Catecholamine 4 75.00 Quite High
Pain 7 73.48 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 174 99.88 Very High Very High Very High
Adenocarcinoma 6 98.54 Very High Very High Very High
Disease 41 98.20 Very High Very High Very High
Leiomyosarcoma 177 97.60 Very High Very High Very High
Obesity 9 97.48 Very High Very High Very High
Cancer 105 77.92 Quite High
Eosinophilia 6 76.56 Quite High
Hypercalcemia 6 75.92 Quite High
Uterine Fibroids 9 74.32 Quite High
Pain 3 73.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Radioligand saturation experiments with the nonselective beta-antagonist 125I-cyanopindolol and competition experiments between this radioligand and the selective antagonists CGP-20,712-A (beta 1) and ICI-118551 (beta 2) showed a 2-fold increase in the amount of beta 1- and beta 2-adrenergic receptors in omental as compared to sc fat cells (P less than 0.02).
Positive_regulation (increase) of beta 1 in fat cells associated with antagonist and obesity
1) Confidence 0.60 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 1320047 Disease Relevance 0.36 Pain Relevance 0.46
treatment in human uterine LMS cell lines, although cervical epithelial adenocarcinoma cell lines and normal human uterus smooth muscle cells underwent strong induction of LMP2 following IFN-?
Positive_regulation (induction) of LMP2 in uterine associated with adenocarcinoma and leiomyosarcoma
2) Confidence 0.46 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.92 Pain Relevance 0
The main effect of vibration, compared to its unstimulated baseline, consisted in an increase of beta-1 (14-20 Hz) power in the right frontal region.
Positive_regulation (increase) of beta-1
3) Confidence 0.46 Published 2000 Journal Clin Neurophysiol Section Body Doc Link 11090762 Disease Relevance 0.06 Pain Relevance 0
signalling pathway, thus the loss of LMP2 induction is attributable to a defect in the earliest steps of the IFN-?
Positive_regulation (induction) of LMP2
4) Confidence 0.43 Published 2008 Journal Gene Regulation and Systems Biology Section Abstract Doc Link PMC2733082 Disease Relevance 0.90 Pain Relevance 0.09
The LMP2 gene is transcribed from a promoter containing an interferon (IFN)-?
Positive_regulation (transcribed) of LMP2
5) Confidence 0.43 Published 2008 Journal Gene Regulation and Systems Biology Section Abstract Doc Link PMC2733082 Disease Relevance 1.03 Pain Relevance 0.11
This result was further confirmed by anti-LMP2 and anti-Olig2 labeling of the same MS brain area where oligodendrocytes were positive to both LMP2 and the oligodendrocytes transcription factor Olig2, while other cells were only stained for LMP2 (Fig. 3B).
Positive_regulation (positive) of LMP2 in brain associated with multiple sclerosis
6) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.44 Pain Relevance 0.09
[39] and golli MBP [40] during EAE, are positive to LMP2 and PA28-??
Positive_regulation (positive) of LMP2 associated with multiple sclerosis
7) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.57 Pain Relevance 0.15
Beta-2 and alpha-2 adrenoceptors are resistant in this respect whereas activation of beta-1 adrenoceptors leads to rapid desensitization.
Positive_regulation (activation) of beta-1
8) Confidence 0.11 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1681086 Disease Relevance 0.07 Pain Relevance 0.44

General Comments

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