INT60187

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Context Info
Confidence 0.43
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 12
Disease Relevance 11.43
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
fat 7
Band 2
plasma 1
body 1
Lbm1 (Mus musculus)
Pain Link Frequency Relevance Heat
rapifen 6 98.64 Very High Very High Very High
cytokine 143 91.24 High High
anesthesia 1 91.24 High High
Neuropeptide 22 71.48 Quite High
antagonist 33 51.36 Quite High
Inflammation 55 5.00 Very Low Very Low Very Low
Buprenorphine 22 5.00 Very Low Very Low Very Low
analgesia 22 5.00 Very Low Very Low Very Low
agonist 22 5.00 Very Low Very Low Very Low
Central nervous system 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Weight Gain 55 99.96 Very High Very High Very High
Myocardial Infarction 1144 98.84 Very High Very High Very High
Targeted Disruption 11 97.48 Very High Very High Very High
Appetite Loss 495 96.76 Very High Very High Very High
Frailty 11 96.48 Very High Very High Very High
Body Weight 121 96.04 Very High Very High Very High
Weight Loss 33 93.96 High High
Hypertrophy 22 93.08 High High
Congenital Anomalies 11 91.72 High High
Fatty Liver 22 85.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an initial group of four patients, who received a simple two-stage infusion, plasma alfentanil concentration was measured at frequent intervals and Ep(L.min-1.kg LBM-1) was estimated at each sampling time.
Positive_regulation (estimated) of LBM-1 in plasma associated with rapifen
1) Confidence 0.43 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 8452267 Disease Relevance 0 Pain Relevance 0.26
Eight weeks after surgery, WT-Sham mice had significant increases in lean body mass (LBM; P<0·05) and fat mass (P<0·05), whereas WT-MI did not gain significant amounts of LBM or fat mass.
Positive_regulation (increases) of LBM in body associated with myocardial infarction
2) Confidence 0.11 Published 2010 Journal The Journal of Endocrinology Section Abstract Doc Link PMC2887273 Disease Relevance 0.95 Pain Relevance 0.03
AGRP treatment in banded rats was effective in attenuating the cachectic state as evidenced by the significant increases in food intake, LBM, and fat mass accumulation while receiving treatment.
Positive_regulation (increases) of LBM in fat
3) Confidence 0.11 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.79 Pain Relevance 0
Significant accumulation of LBM and fat mass after surgery occurred in WT-Sham mice, but not in WT-MI mice (Table 1).
Positive_regulation (accumulation) of LBM in fat associated with myocardial infarction
4) Confidence 0.11 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 1.58 Pain Relevance 0
The ability of genetic and pharmacologic blockade of melanocortin signaling to increase both LBM and fat mass in rodent models of CHF suggests that compounds that selectively antagonize central melanocortin signaling may have important pharmacotherapeutic benefits for cachectic CHF patients.


Positive_regulation (increase) of LBM in fat associated with myocardial infarction
5) Confidence 0.11 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 1.20 Pain Relevance 0.05
AGRP treatment significantly increased LBM per animal in banded rats when expressed both as a percent of baseline (Band-aCSF 3·39±2·50% versus Band-AGRP 17·90±2·29%, P<0·001; Fig. 4) and when expressed as absolute grams of tissue (Band-aCSF 7·12±5·57?
Positive_regulation (increased) of LBM in Band
6) Confidence 0.08 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.66 Pain Relevance 0
Weight gain, LBM, fat mass accumulation, and kidney weights and liver weights were significantly increased by AGRP treatment in banded rats (Band-aCSF versus Band-AGRP; Table 2).
Positive_regulation (increased) of LBM in fat associated with weight gain
7) Confidence 0.08 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.79 Pain Relevance 0
The percent increase in LBM per animal over the course of the study was higher in Sham-aCSF rats compared to Band-aCSF rats (Sham-aCSF 11·62±2·04% versus Band-aCSF 3·39±2·50%, P<0·05; Fig. 4).
Positive_regulation (increase) of LBM in Band
8) Confidence 0.08 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.66 Pain Relevance 0
There was no difference in the percent increase in LBM (Fig. 2) and fat mass (Table 1) per animal over the course of the study for MC4-Sham mice compared with MC4-MI mice, and both groups were significantly higher compared to WT-Sham mice (Fig. 2).
Positive_regulation (increase) of LBM in fat associated with myocardial infarction
9) Confidence 0.07 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 1.29 Pain Relevance 0
At the beginning of the treatment period, banded rats were hypophagic, and had reduced BWs, LBM, and fat mass accumulation compared to sham-operated rats.
Positive_regulation (accumulation) of LBM in fat
10) Confidence 0.07 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 1.07 Pain Relevance 0
The percent increase in LBM per animal over the course of the study was significantly higher for WT-Sham mice compared with WT-MI mice (WT-Sham 11·24±1·11% versus WT-MI 1·73±1·27%, P<0·001; Fig. 2).
Positive_regulation (increase) of LBM associated with myocardial infarction
11) Confidence 0.07 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 1.53 Pain Relevance 0
In contrast, MC4-MI mice as a group did not become cachectic as shown by their normal accumulation of LBM, fat mass, and overall normal gross organ weights as compared to MC4-Sham mice.
Positive_regulation (accumulation) of LBM in fat associated with myocardial infarction
12) Confidence 0.07 Published 2010 Journal The Journal of Endocrinology Section Body Doc Link PMC2887273 Disease Relevance 0.90 Pain Relevance 0.04

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