INT60188

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Context Info
Confidence 0.70
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.04
Pain Relevance 4.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2d4) oxidoreductase activity (Cyp2d4) endoplasmic reticulum (Cyp2d4)
cellular_component (Cyp2d4) cytoplasm (Cyp2d4)
Anatomy Link Frequency
liver 2
plasma 1
Cyp2d4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dextromethorphan 25 98.36 Very High Very High Very High
Oxycodone 204 97.92 Very High Very High Very High
fluoxetine 2 88.72 High High
Catechol-O-methyltransferase 5 81.56 Quite High
opioid receptor 24 76.80 Quite High
Antinociceptive 4 74.88 Quite High
antagonist 3 73.28 Quite High
lidocaine 10 72.88 Quite High
analgesia 18 66.68 Quite High
Paracetamol 5 63.52 Quite High
Disease Link Frequency Relevance Heat
Mycobacterial Infection 34 96.20 Very High Very High Very High
Hepatotoxicity 19 92.96 High High
Hypotension 2 88.88 High High
Adverse Drug Reaction 4 87.44 High High
Death 12 69.24 Quite High
Toxicity 10 67.20 Quite High
Cancer Pain 40 50.00 Quite Low
Schizophrenia 39 50.00 Quite Low
Drug Induced Neurotoxicity 20 50.00 Quite Low
Sprains And Strains 5 38.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, sodium ozagrel metabolism in rats is mediated primarily through CYP2D6, and sodium ozagrel can induce CYP2D6 activity.
Positive_regulation (induce) of CYP2D6
1) Confidence 0.70 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17651725 Disease Relevance 0 Pain Relevance 0.07
In conclusion, sodium ozagrel metabolism in rats is mediated primarily through CYP2D6, and sodium ozagrel can induce CYP2D6 activity.
Positive_regulation (mediated) of CYP2D6
2) Confidence 0.47 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17651725 Disease Relevance 0 Pain Relevance 0.09
DM is commonly used as a probe for phenotyping subjects as either poor or extensive metabolizers for the debrisoquine/sparteine oxidative polymorphism via CYP2D6.
Positive_regulation (metabolizers) of CYP2D6 associated with dextromethorphan
3) Confidence 0.44 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8452558 Disease Relevance 0 Pain Relevance 0.23
The conversion of oxycodone to oxymorphone, as well as the conversion of noroxycodone to noroxymorphone are catalyzed by the liver enzyme cytochrome P4502D6 (CYP2D6) (Figure 1) (Kress 2005)
Positive_regulation (enzyme) of cytochrome P4502D6 in liver associated with oxycodone
4) Confidence 0.41 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936259 Disease Relevance 0 Pain Relevance 1.72
The conversion of oxycodone to oxymorphone, as well as the conversion of noroxycodone to noroxymorphone are catalyzed by the liver enzyme cytochrome P4502D6 (CYP2D6) (Figure 1) (Kress 2005)
Positive_regulation (enzyme) of CYP2D6 in liver associated with oxycodone
5) Confidence 0.41 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936259 Disease Relevance 0 Pain Relevance 1.73
Three are believed to be alleles of CYP2D1, 2D2, and 2D3, respectively, based on high nucleotide sequence similarity, while CYP2D4 had both sequences of CYP2D4 and CYP2D18.
Positive_regulation (sequences) of CYP2D4
6) Confidence 0.40 Published 1997 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 9434752 Disease Relevance 0 Pain Relevance 0.13
Three are believed to be alleles of CYP2D1, 2D2, and 2D3, respectively, based on high nucleotide sequence similarity, while CYP2D4 had both sequences of CYP2D4 and CYP2D18.
Positive_regulation (sequences) of CYP2D18
7) Confidence 0.40 Published 1997 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 9434752 Disease Relevance 0 Pain Relevance 0.13
For example, rifampicin is a potent inducer of CYP2D6 and CYP3A4, and isoniazid induces CYP2E1 [6,7].
Positive_regulation (inducer) of CYP2D6
8) Confidence 0.34 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2491620 Disease Relevance 0.95 Pain Relevance 0.06
Enhanced plasma and tissue levels of MDMA are most likely related to auto-inhibition of MDMA metabolism, mediated via formation of a metabolite–enzyme complex that irreversibly inactivates CYP2D6 (Wu et al. 1997).
Positive_regulation (inactivates) of CYP2D6 in plasma
9) Confidence 0.32 Published 2006 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1705495 Disease Relevance 0 Pain Relevance 0.08
The importance of CYP2D6 and CYP3A4 in sertindole clearance is underlined by its interactions with potent inhibitors of these isoenzymes.
Positive_regulation (importance) of CYP2D6
10) Confidence 0.19 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2939763 Disease Relevance 0.09 Pain Relevance 0.11

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