INT6019

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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 37
Total Number 40
Disease Relevance 17.30
Pain Relevance 8.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NEUROD1) nucleus (NEUROD1) transcription factor binding (NEUROD1)
cytoplasm (NEUROD1)
Anatomy Link Frequency
plasma 3
heart 2
urine 2
plasma cells 1
ventricular myocardium 1
NEUROD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 23 100.00 Very High Very High Very High
sodium channel 5 99.96 Very High Very High Very High
noradrenaline 3 99.24 Very High Very High Very High
Catecholamine 8 99.20 Very High Very High Very High
beta blocker 18 99.14 Very High Very High Very High
anesthesia 14 99.08 Very High Very High Very High
antagonist 19 98.74 Very High Very High Very High
epidural 6 98.64 Very High Very High Very High
Potency 3 98.56 Very High Very High Very High
antidepressant 3 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 10 100.00 Very High Very High Very High
Amyloidosis 4 99.88 Very High Very High Very High
Injury 4 99.84 Very High Very High Very High
Myocardial Infarction 23 99.58 Very High Very High Very High
Cancer 84 99.52 Very High Very High Very High
Adenoma 79 99.46 Very High Very High Very High
Neuropathic Pain 10 99.46 Very High Very High Very High
Coronary Artery Disease 20 99.20 Very High Very High Very High
Heart Rate Under Development 4 99.04 Very High Very High Very High
Stress 35 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No abnormal laboratory test results were obtained other than increases in beta 2-microglobulin, NAG and gamma-GTP levels, each of which returned to normal after the completion of ABK administration.
Positive_regulation (increases) of beta 2
1) Confidence 0.67 Published 1994 Journal Jpn J Antibiot Section Abstract Doc Link 8072176 Disease Relevance 0.46 Pain Relevance 0.09
The nuclear increase of PKC-alpha, -beta1, and -beta2 was due to a translocation from the cytosolic compartment.
Positive_regulation (increase) of beta2 associated with kinase c
2) Confidence 0.67 Published 2003 Journal Circ. Res. Section Abstract Doc Link 12623877 Disease Relevance 0 Pain Relevance 0.77
The absence of a significant efficacy of celiprolol, a beta blocker with vasodilator properties, but exerting stimulation of beta2 receptors, suggests an unfavorable role of this latter property in heart failure.
Positive_regulation (stimulation) of beta2 in heart associated with beta blocker and myocardial infarction
3) Confidence 0.67 Published 2000 Journal Am. J. Cardiol. Section Abstract Doc Link 10856394 Disease Relevance 0.26 Pain Relevance 0.25
In conclusion, these observations suggest that the initial drop in s-Mg and s-K in the early phase of AMI is due to increased stimulation of beta 2-adrenergic receptors; these changes can be prevented partly or completely by the use of nonselective beta-blockers.
Positive_regulation (stimulation) of beta 2 associated with beta blocker and myocardial infarction
4) Confidence 0.67 Published 1993 Journal Angiology Section Abstract Doc Link 8097620 Disease Relevance 0.37 Pain Relevance 0.16
Dopexamine, a new synthetic amine, possesses positive inotropic effects by indirect stimulation of the beta 1-receptors and direct stimulation of the beta 2-receptors.
Positive_regulation (stimulation) of beta 2
5) Confidence 0.67 Published 1993 Journal Z Kardiol Section Abstract Doc Link 7904788 Disease Relevance 0.25 Pain Relevance 0.27
Increased stimulation of beta 1- and beta 2-receptors in the heart increases heart rate and contractility and thereby myocardial oxygen demand.
Positive_regulation (stimulation) of beta 2 in heart associated with heart rate under development
6) Confidence 0.67 Published 1984 Journal Drugs Section Abstract Doc Link 6151892 Disease Relevance 0.87 Pain Relevance 0.21
Beta 2-receptors are activated by isoproterenol, noradrenaline and adrenaline in precontracted veins (part of the facial vein of the rabbit may be an exception).
Positive_regulation (activated) of Beta 2 in facial vein associated with noradrenaline
7) Confidence 0.67 Published 1986 Journal J Pharmacol Section Abstract Doc Link 2881027 Disease Relevance 0.08 Pain Relevance 0.05
Stimulation of either beta 1- or beta 2-receptors results in a positive chronotropic and inotropic response.
Positive_regulation (Stimulation) of beta 2
8) Confidence 0.67 Published 1990 Journal Pharmacol. Ther. Section Abstract Doc Link 1969643 Disease Relevance 0.09 Pain Relevance 0.07
Patients developed moderate increases of serum levels of soluble interleukin-2 receptors, beta 2-microglobin, and immunoglobulin M (IgM), and of the acute phase reactants, C-reactive protein (CRP), fibrinogen, and haptoglobin.
Positive_regulation (increases) of beta 2
9) Confidence 0.67 Published 1991 Journal J. Clin. Oncol. Section Abstract Doc Link 1960553 Disease Relevance 0.32 Pain Relevance 0.07
These results suggest a possible involvement of plasma ubiquitin in beta 2-M amyloidosis.
Spec (possible) Positive_regulation (involvement) of beta 2 in plasma associated with amyloidosis
10) Confidence 0.49 Published 1993 Journal Clin. Chim. Acta Section Abstract Doc Link 8111958 Disease Relevance 0.56 Pain Relevance 0.09
Increases in serum interferon, beta 2-microglobulin, and neopterin correlated significantly with dose (P < 0.001).
Positive_regulation (Increases) of beta 2
11) Confidence 0.49 Published 1993 Journal Cancer Res. Section Abstract Doc Link 8221654 Disease Relevance 0.72 Pain Relevance 0.08
This effect is mediated through the upregulation of beta 2 integrins on the PMN surface.
Positive_regulation (upregulation) of beta 2 in PMN
12) Confidence 0.49 Published 1997 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 9218092 Disease Relevance 0 Pain Relevance 0.17
Since R-salbutamol relaxes human isolated bronchus, the capacity of S-salbutamol to enhance contractile responses to histamine or LTC4 cannot be attributed to activation of beta2-adrenoceptors.
Positive_regulation (activation) of beta2 in bronchus
13) Confidence 0.49 Published 1998 Journal Pulm Pharmacol Ther Section Abstract Doc Link 9802957 Disease Relevance 0.18 Pain Relevance 0.13
Some forms of stress and epinephrine infusions increase fibrinolysis, probably by stimulating beta 2-adrenoceptors.
Positive_regulation (stimulating) of beta 2 associated with stress
14) Confidence 0.49 Published 1991 Journal Circulation Section Abstract Doc Link 1683612 Disease Relevance 1.12 Pain Relevance 0.35
Co-cultures of odontoblasts with trigeminal neurons indicate a clustering of alpha2 and beta2 sodium channel subunits and, at the sites of cell-cell contact, a co-localization of odontoblasts beta2 subunits with peripherin.
Positive_regulation (clustering) of beta2 in neurons associated with sodium channel
15) Confidence 0.49 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16831873 Disease Relevance 0.16 Pain Relevance 0.53
These variations in catecholamine receptor mRNAs correlated with a clear induction in the density of beta2- and beta3-AR proteins, and in the potency of beta-AR subtype-selective agonists to stimulate adenylyl cyclase activity.
Spec (clear) Positive_regulation (induction) of beta2 associated with catecholamine, agonist and potency
16) Confidence 0.49 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12149260 Disease Relevance 0.28 Pain Relevance 0.32
RESULTS: The statistical analysis showed an increase in the values of anticardiolipin antibodies (aCL), anti beta2-glycoprotein 1 (beta2-GP1) and Thm in children with stroke and migraine than in the control group.
Positive_regulation (increase) of beta2
17) Confidence 0.49 Published 2006 Journal Acta Neurol. Scand. Section Body Doc Link 16774621 Disease Relevance 0.17 Pain Relevance 0
The positive inotropic action of ciguatoxin-1 did not stem from a significant direct action on myocardial voltage-dependent sodium channels, nor did it stem from significant alpha 1- or beta 2-adrenoreceptor stimulation.
Positive_regulation (stimulation) of beta 2 in stem associated with sodium channel
18) Confidence 0.49 Published 1992 Journal Toxicon Section Abstract Doc Link 1523682 Disease Relevance 0.16 Pain Relevance 0.22
Human studies suggest that anti-cardiolipin and anti-beta2-glycoprotein-I antibodies are elevated in patients having coronary artery disease compared with controls.
Positive_regulation (elevated) of beta2 in coronary artery associated with coronary artery disease
19) Confidence 0.49 Published 2003 Journal Immunobiology Section Abstract Doc Link 12638897 Disease Relevance 0.90 Pain Relevance 0.09
On the other hand, levels of circulating beta 2-microglobulin, SCD8, SIL-2R, and HIV p24 antigen were significantly elevated in the HIV-seropositive group compared with the HIV-seronegative group.
Positive_regulation (elevated) of beta 2 associated with acquired immune deficiency syndrome or hiv infection
20) Confidence 0.49 Published 1989 Journal AIDS Section Abstract Doc Link 2500957 Disease Relevance 1.21 Pain Relevance 0.18

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