INT60196

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Context Info
Confidence 0.47
First Reported 1993
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 33
Total Number 35
Disease Relevance 13.11
Pain Relevance 6.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOS) aging (FOS) nucleolus (FOS)
nucleus (FOS)
Anatomy Link Frequency
glial cells 1
neurons 1
apoptotic cell 1
adrenal gland 1
cortex 1
FOS (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 32 100.00 Very High Very High Very High
Dorsal horn 11 100.00 Very High Very High Very High
nud 8 100.00 Very High Very High Very High
Dynorphin 34 99.72 Very High Very High Very High
Sciatic nerve 1 99.68 Very High Very High Very High
Pain 29 99.24 Very High Very High Very High
Enkephalin 15 99.16 Very High Very High Very High
Opioid 7 98.00 Very High Very High Very High
spinal dorsal horn 2 97.68 Very High Very High Very High
Cholecystokinin 5 97.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dyspepsia 8 100.00 Very High Very High Very High
Apoptosis 211 99.76 Very High Very High Very High
Breast Cancer 56 99.76 Very High Very High Very High
Death 207 99.16 Very High Very High Very High
Infection 54 98.88 Very High Very High Very High
Cancer 143 98.48 Very High Very High Very High
Injury 152 98.16 Very High Very High Very High
Stress 372 96.88 Very High Very High Very High
Neuroma 1 96.36 Very High Very High Very High
Neuropathic Pain 5 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the mechanism is unknown, it appears that the interaction of an electromagnetic field and c-fos proteins may alter normal transmission of painful impulses.
c-fos Binding (interaction) of associated with pain
1) Confidence 0.47 Published 2006 Journal Mt. Sinai J. Med. Section Abstract Doc Link 16878278 Disease Relevance 0.66 Pain Relevance 0.77
Conversely, the number of nuclei immunostained with an antibody that recognizes all proteins of the Fos family was not modified by the same dose combination compared to single treatment (21.1 +/- 1.3 vs. 20.2 +/- 1.2).
Fos Binding (recognizes) of
2) Confidence 0.47 Published 1998 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9698203 Disease Relevance 0.09 Pain Relevance 1.12
Nuclei immunoreactive for c-Fos (c-Fos Ir) were counted as particles in each of the three divisions of the IC, dorsal cortex (DCIC), lateral cortex (LCIC), and central nucleus (CNIC).
c-Fos Binding (immunoreactive) of in cortex
3) Confidence 0.36 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2981384 Disease Relevance 0 Pain Relevance 0
After confirmation of layers in the spinal dorsal horn in accordance with reports by Molander et al. [8], images at 400× magnification were imported into the computer to check for c-Fos-immunoreactive neurons.
c-Fos Binding (check) of in neurons associated with spinal dorsal horn
4) Confidence 0.36 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2276498 Disease Relevance 0.12 Pain Relevance 0.29
Comparison of c-fos staining pattern with ?
c-fos Binding (Comparison) of
5) Confidence 0.36 Published 2008 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2362139 Disease Relevance 0 Pain Relevance 0.22
An experiment with PRV and c-fos has to be careful that PRV infection itself does not affect c-fos expression.
c-fos Binding (experiment) of associated with infection
6) Confidence 0.36 Published 2008 Journal Yonsei Medical Journal Section Body Doc Link PMC2615335 Disease Relevance 0.72 Pain Relevance 0.07
We tested whether the production of begging calls was associated with the forebrain song circuits by using an immediate early gene, c-fos, as a neural activity marker [27].
c-fos Spec (whether) Binding (associated) of in neural
7) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2691483 Disease Relevance 0.42 Pain Relevance 0
Expression of three of the immediate early genes examined, c-fos, NGFI-A and jun B, was transiently increased in the ipsilateral dorsal horn of the spinal cord following the partial ligation of the sciatic nerve.
c-fos Spec (partial) Binding (ligation) of in dorsal horn associated with dorsal horn, sciatic nerve and spinal cord
8) Confidence 0.36 Published 1997 Journal Acta Physiol. Scand. Section Abstract Doc Link 9429660 Disease Relevance 0.46 Pain Relevance 0.56
The tax1 induced c-Fos protein levels and the concurrently increased association of c-Fos/c-Jun transcription factors at the AP-1 site imply a strong functional significance in the activation of proenkephalin gene expression in tax1 expressing glial cells.
c-Fos Binding (association) of in glial cells
9) Confidence 0.36 Published 1997 Journal J. Neurovirol. Section Abstract Doc Link 9147818 Disease Relevance 0 Pain Relevance 0.13
These data suggest enkephalin gene expression in the adrenal gland is controlled by cell-specific binding of transcription factors from the Fos/Jun families to the enkephalin CRE-2 element.
Fos Binding (binding) of in adrenal gland associated with enkephalin
10) Confidence 0.35 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8931456 Disease Relevance 0.07 Pain Relevance 0.68
In this study, DYN peptide and mRNA levels, as well as Fos/FRA proteins and AP-1 DNA binding activity, were measured in individual animals following acute challenge with the psychostimulant drug methamphetamine (METH).
Fos Binding (binding) of associated with dynorphin
11) Confidence 0.35 Published 1996 Journal Biol. Signals Section Abstract Doc Link 9116798 Disease Relevance 0 Pain Relevance 0.51
Analyses of the time course of METH's effects revealed that DYN mRNA levels, Fos/FRA proteins and AP-1 binding activity showed variable increases by 3 h but all were significantly elevated above control levels by 6 h posttreatment.
Fos Binding (activity) of associated with dynorphin
12) Confidence 0.35 Published 1996 Journal Biol. Signals Section Abstract Doc Link 9116798 Disease Relevance 0 Pain Relevance 0.62
In this study, DYN peptide and mRNA levels, as well as Fos/FRA proteins and AP-1 DNA binding activity, were measured in individual animals following acute challenge with the psychostimulant drug methamphetamine (METH).
Fos Binding (activity) of associated with dynorphin
13) Confidence 0.35 Published 1996 Journal Biol. Signals Section Abstract Doc Link 9116798 Disease Relevance 0 Pain Relevance 0.51
This suggests that Fos/Jun homo- or heterodimeric complexes may interact with the 5'-CTGCGTCAGCG-3' motif, present within the human CCK promoter.
Fos Binding (interact) of associated with cholecystokinin
14) Confidence 0.33 Published 1993 Journal Neuroreport Section Abstract Doc Link 8453059 Disease Relevance 0.09 Pain Relevance 0.25
via AP-1 complex [32,40].
AP-1 Binding (complex) of
15) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2567989 Disease Relevance 1.26 Pain Relevance 0.07
Interestingly, FOS has been associated with breast cancer in a number of studies [41-44].
FOS Binding (associated) of associated with breast cancer
16) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2567989 Disease Relevance 1.08 Pain Relevance 0.09
Since FOS has previously been associated with ischemic conditions [20,30,31], we hypothesized that this observation was due to the duration of exposure to hypoxia.
FOS Binding (associated) of associated with hypoxia
17) Confidence 0.31 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2567989 Disease Relevance 0.29 Pain Relevance 0
Compared to placebo, we did not find any significant digestive intolerance symptoms except minor bloating with scFOS.
scFOS Neg (except) Binding (bloating) of associated with nud
18) Confidence 0.31 Published 2006 Journal Nutr J Section Body Doc Link PMC1448190 Disease Relevance 0.64 Pain Relevance 0.14
For example, ErbB3, fos, TGF?
fos Binding (example) of
19) Confidence 0.29 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.41 Pain Relevance 0
Hence we believe that giving both FOS and ACEi to all patients in the proposed study is warranted and will greatly enhance patient recruitment by providing some form of treatment for all subjects in the trial.
FOS Binding (giving) of
20) Confidence 0.24 Published 2004 Journal BMC Nephrol Section Body Doc Link PMC415550 Disease Relevance 0.35 Pain Relevance 0.08

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