INT60197

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 90
Total Number 95
Disease Relevance 42.32
Pain Relevance 14.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (JUN) nucleoplasm (JUN) nuclear chromosome (JUN)
aging (JUN) nucleus (JUN) DNA binding (JUN)
Anatomy Link Frequency
alpha cells 3
endothelial cells 3
neurons 3
brain 2
A549 2
JUN (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 369 100.00 Very High Very High Very High
Inflammation 355 100.00 Very High Very High Very High
cytokine 221 100.00 Very High Very High Very High
calcitonin gene related peptide 18 99.92 Very High Very High Very High
Dorsal horn neuron 3 99.84 Very High Very High Very High
Morphine 30 99.80 Very High Very High Very High
opioid receptor 10 99.68 Very High Very High Very High
Chronic pancreatitis 27 99.62 Very High Very High Very High
Central nervous system 29 99.32 Very High Very High Very High
electroacupuncture 8 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 439 100.00 Very High Very High Very High
Adhesions 48 100.00 Very High Very High Very High
Pancreatic Cancer 54 99.88 Very High Very High Very High
Targeted Disruption 47 99.88 Very High Very High Very High
Pancreatitis 28 99.62 Very High Very High Very High
Poisoning 35 99.58 Very High Very High Very High
Cancer 616 99.52 Very High Very High Very High
Osteoporosis 22 99.48 Very High Very High Very High
Lymphatic System Cancer 138 99.28 Very High Very High Very High
Stress 121 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes on a molecular level in peripheral tissue as well as in the central nervous system induce "cellular early genes", a synthesis of c-fos, c-jun and other proteins favouring the chronification of pain.
Gene_expression (synthesis) of c-jun in central nervous system associated with pain and central nervous system
1) Confidence 0.78 Published 1997 Journal Anaesthesist Section Abstract Doc Link 9412270 Disease Relevance 1.44 Pain Relevance 1.10
Normal pancreas and chronic pancreatitis tissues appear to express the c-jun protein in less than 10% of ductal cells.
Gene_expression (express) of c-jun in pancreas associated with chronic pancreatitis
2) Confidence 0.77 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.87 Pain Relevance 0.32
The frequency of high or low c-jun expression is not different in relation to the histological features of tumor.
Gene_expression (expression) of c-jun associated with cancer
3) Confidence 0.77 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.92 Pain Relevance 0.31
The aims of this study were to evaluate a) the expression of c-jun oncogene in pancreatic cancer b) its relation with tumor histological features.
Gene_expression (expression) of c-jun associated with cancer and pancreatic cancer
4) Confidence 0.77 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.53 Pain Relevance 0.16
Glucagon and somatostatin staining was graded counting the positive cells of total numer of Langherans islet cells counted. c-Jun expression (low: < 30% and high: > 30%) was related to stage, architectural and cytological grading, vascular, lymph nodal, perineural invasion.
Gene_expression (expression) of c-Jun in lymph associated with somatostatin
5) Confidence 0.77 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.69 Pain Relevance 0.26
In conclusion; a) in pancreatic cancer, the expression of c-jun is increased in tumour cells in majority of cases as compared to the control group, b) a c-jun positivity is also found in alpha cells with a pattern not different from control group, but the relation between the alpha cells and c-jun production is unknown, c) c-jun expression does not vary in relation to histological findings.
Gene_expression (production) of c-jun in alpha cells associated with cancer and pancreatic cancer
6) Confidence 0.77 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.64 Pain Relevance 0.17
In conclusion; a) in pancreatic cancer, the expression of c-jun is increased in tumour cells in majority of cases as compared to the control group, b) a c-jun positivity is also found in alpha cells with a pattern not different from control group, but the relation between the alpha cells and c-jun production is unknown, c) c-jun expression does not vary in relation to histological findings.
Gene_expression (expression) of c-jun in alpha cells associated with cancer and pancreatic cancer
7) Confidence 0.77 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.64 Pain Relevance 0.17
It resulted in an inhibition of AP-1-driven reporter gene activity and of the expression of the AP-1 target gene interleukin-3.
Gene_expression (expression) of AP-1
8) Confidence 0.77 Published 2004 Journal Anesthesiology Section Body Doc Link 15329596 Disease Relevance 0 Pain Relevance 0
In vitro run-off transcription and Western blot analysis revealed the expression of the protooncogenes Fos and Jun.
Gene_expression (expression) of Jun
9) Confidence 0.75 Published 1993 Journal Neuroreport Section Abstract Doc Link 8453059 Disease Relevance 0.09 Pain Relevance 0.25
Various IEGs of fos, jun, and zinc finger families are differentially expressed in dorsal horn neurons in a time dependent manner.
Gene_expression (expressed) of jun in neurons associated with dorsal horn neuron
10) Confidence 0.75 Published 1996 Journal Masui Section Abstract Doc Link 8847779 Disease Relevance 0.36 Pain Relevance 0.73
in the expression of both COX-2 and c-Jun proteins and mRNAs.
Gene_expression (expression) of c-Jun
11) Confidence 0.75 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.98 Pain Relevance 0.03
Interestingly, although increased expression of the c-jun transcription factor contributes to NRG1-induced demyelination, its phosphorylation by JNK is not essential to mediate Schwann cell degeneration (Parkinson et al., 2008).
Gene_expression (expression) of c-jun in Schwann cell associated with demyelination
12) Confidence 0.75 Published 2010 Journal ASN NEURO Section Body Doc Link PMC2919983 Disease Relevance 0.80 Pain Relevance 0.14
Genomic expression profile with vitamin D indicated differential expression of gene targets such as c-JUN, JUNB, JUND, FREAC-1/FoxF1, ZNF-44/KOX7, plectin, filamin, and keratin-13, involved in antiproliferative, differentiation pathways.
Gene_expression (expression) of c-JUN
13) Confidence 0.75 Published 2006 Journal Curr Cancer Drug Targets Section Abstract Doc Link 17168675 Disease Relevance 0.29 Pain Relevance 0.06
Moreover, c-jun protein is present in 40% of cells of Langherans islets in normal pancreas, chronic pancreatitis and pancreatic cancer.
Gene_expression (present) of c-jun in pancreas associated with pancreatic cancer and chronic pancreatitis
14) Confidence 0.67 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.94 Pain Relevance 0.28
In conclusion; a) in pancreatic cancer, the expression of c-jun is increased in tumour cells in majority of cases as compared to the control group, b) a c-jun positivity is also found in alpha cells with a pattern not different from control group, but the relation between the alpha cells and c-jun production is unknown, c) c-jun expression does not vary in relation to histological findings.
Gene_expression (expression) of c-jun in alpha cells associated with cancer and pancreatic cancer
15) Confidence 0.67 Published 1999 Journal Anticancer Res. Section Abstract Doc Link 10216507 Disease Relevance 0.76 Pain Relevance 0.25
The expression results for the genes JUN (c-jun) and VHL (von Hippel-Lindau) did not match the literature [18,19].
Gene_expression (expression) of JUN
16) Confidence 0.67 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.13 Pain Relevance 0
The expression results for the genes JUN (c-jun) and VHL (von Hippel-Lindau) did not match the literature [18,19].
Gene_expression (expression) of c-jun
17) Confidence 0.67 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.13 Pain Relevance 0
Expression of a c-Jun NH(2)-terminal protein kinase (JNK), also known as stress-activated protein kinase (SAPK) in rodents, has been implicated in the ability of cells to respond to a variety of stressors.
Gene_expression (Expression) of c-Jun associated with stress
18) Confidence 0.65 Published 2000 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 10950813 Disease Relevance 0.18 Pain Relevance 0.04
Environmental stress signals (ultraviolet light, heat or synthesis inhibitors) have been shown to activate the c-jun NH2- terminal kinase (JNK) and p38 MAPK pathways, which resulted in stress responses, growth arrest and/or apoptosis [16].
Gene_expression (pathways) of c-jun associated with stress and apoptosis
19) Confidence 0.65 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2864039 Disease Relevance 1.08 Pain Relevance 0
We hypothesized that increased prostaglandin production by Cox-2 induces PKC and the expression of transcriptional factor c-Jun, which in turn, induces the expression of MDR1/Pgp170.
Gene_expression (expression) of c-Jun
20) Confidence 0.62 Published 2001 Journal Anticancer Res. Section Body Doc Link 11501838 Disease Relevance 0.06 Pain Relevance 0

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