INT602

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Context Info
Confidence 0.25
First Reported 1976
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.50
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TAS1R3) signal transducer activity (TAS1R3)
TAS1R3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 56 99.92 Very High Very High Very High
Nicotine 32 78.40 Quite High
agonist 36 36.80 Quite Low
Pain 7 25.00 Low Low
alcohol 6 5.00 Very Low Very Low Very Low
Acupuncture 6 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
qutenza 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroiditis 4 95.72 Very High Very High Very High
Targeted Disruption 28 90.68 High High
Ocular Toxicity (including Many Sub-types) 1 84.80 Quite High
Hyperthyroidism 2 75.00 Quite High
Thyroid Disease 1 25.00 Low Low
Pain 6 5.00 Very Low Very Low Very Low
Aging 4 5.00 Very Low Very Low Very Low
Overdose 2 5.00 Very Low Very Low Very Low
Taste Disorders 2 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, at 45 °C both the GalA-MRP–induced increase in the Bz-insensitive NaCl CT response and the GalA-MRP–induced increase in the salt taste perception in humans are most likely due to the amiloride- and Bz-insensitive salt taste receptor and not due to the amiloride-sensitive epithelial Na+ channels.
Positive_regulation (increase) of salt taste receptor
1) Confidence 0.25 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0.10
It is likely that Xyl-MRP and IMP produce their effects on the CT response to MSG by acting on the T1R3 part of the umami taste receptor (T1R1 + T1R3).
Positive_regulation (acting) of T1R3 associated with glutamate
2) Confidence 0.23 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.17 Pain Relevance 0.41
Thyroxine (T4) and triiodothyronine (T3) resin uptakes (T3R) were increased but the 24 hour radioactive iodine (RAI) uptakes were less than 1 per cent.
Positive_regulation (increased) of T3R
3) Confidence 0.11 Published 1976 Journal Am. J. Med. Section Abstract Doc Link 56130 Disease Relevance 0.33 Pain Relevance 0

General Comments

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