From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.52
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Htr1a, Htr2c) signal transducer activity (Htr1a, Htr2c) nucleus (Htr2c)
cytoplasm (Htr2c)
Htr1a (Rattus norvegicus)
Htr2c (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 7 98.40 Very High Very High Very High
Eae 2 96.20 Very High Very High Very High
Anterior cingulate 1 85.60 High High
antagonist 1 85.52 High High
fluoxetine 5 83.08 Quite High
monoamine 2 72.60 Quite High
depression 1 62.04 Quite High
Nortriptyline 1 57.24 Quite High
Endep 1 56.64 Quite High
Desipramine 1 54.40 Quite High
Disease Link Frequency Relevance Heat
Depression 2 64.24 Quite High
Stress 2 63.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the study confirmed that 5-HT1A receptors functionally interact with 5-HT1C receptors, which suggests that some degree of activity at 5-HT1A receptors may also be an important property for antidepressant activity.
5-HT1A Binding (interact) of 5-HT1C associated with antidepressant
1) Confidence 0.52 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8453978 Disease Relevance 0 Pain Relevance 0.58
Quantitative autoradiography was used to determine 5-HT1A and 5-HT2C receptor binding with [O-methyl-(3)H]WAY 100635 and [(3)H]mesulergine (added spiperone and 8-OH-DPAT), respectively.
5-HT1A Binding (binding) of 5-HT2C
2) Confidence 0.39 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19138691 Disease Relevance 0.25 Pain Relevance 0.42

General Comments

This test has worked.

Personal tools