INT6021

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 12.55
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
blood 2
immune system 2
plasma 1
gonadal 1
follicle 1
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 136 99.98 Very High Very High Very High
Dopamine 341 99.80 Very High Very High Very High
Fibrositis 77 98.40 Very High Very High Very High
Catecholamine 1 98.30 Very High Very High Very High
opiate 18 98.00 Very High Very High Very High
Serotonin 129 97.52 Very High Very High Very High
Somatostatin 40 96.48 Very High Very High Very High
gABA 52 96.20 Very High Very High Very High
depression 43 94.80 High High
narcan 8 94.24 High High
Disease Link Frequency Relevance Heat
Rheumatic Diseases 4 99.80 Very High Very High Very High
Chronic Fatigue Syndrome 67 99.44 Very High Very High Very High
Prolactinoma 58 99.30 Very High Very High Very High
Depression 83 98.72 Very High Very High Very High
Galactorrhea 645 98.60 Very High Very High Very High
Fibromyalgia 77 98.40 Very High Very High Very High
Lymphatic System Cancer 2 98.12 Very High Very High Very High
Endocrine Disease 5 97.76 Very High Very High Very High
Stress 49 97.66 Very High Very High Very High
Systemic Lupus Erythematosus 102 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither sheep nor rat prolactin was recognized by Western blot analysis, indicating that the assay may be specific for primate prolactins.
prolactin Binding (recognized) of
1) Confidence 0.48 Published 1992 Journal Lab. Anim. Sci. Section Abstract Doc Link 1320162 Disease Relevance 0 Pain Relevance 0.15
However, lithium-prolactin interactions are probably even more complex and involve both dopamine and serotonin pathways (Basturk et al 2001).


lithium-prolactin Binding (interactions) of associated with dopamine and serotonin
2) Confidence 0.42 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.35 Pain Relevance 0.49
There are several hypotheses to explain the “atypical” behavior on prolactin levels: regional limbic selectivity (Goldstein 1999), preferential binding to D3 and D4 (Kuhn 2000), peculiar binding dynamics at the D2 receptors or differences in affinity to D2 (Seeman 2002), combined antagonism of dopamine and serotonin receptors (Kuhn 2000).
prolactin Binding (binding) of associated with dopamine and serotonin
3) Confidence 0.37 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.10 Pain Relevance 0.46
Trazodone administration was found to increase significantly prolactin concentrations, when measured at baseline and after 12 hours, 1 week and 2 weeks treatment, the means ± S.D. of plasma prolactin concentrations increasing from 9.1 ± 5.6 ng/ml to a maximum of 15.3 +/?
prolactin Binding (concentrations) of in plasma
4) Confidence 0.37 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.18 Pain Relevance 0.26
The subsequent literature review documented an interesting association between prolactin and rheumatic diseases and in particular, hyperprolactinemia and SLE.
prolactin Binding (association) of associated with galactorrhea, systemic lupus erythematosus and rheumatic diseases
5) Confidence 0.36 Published 2009 Journal Pediatr Rheumatol Online J Section Abstract Doc Link PMC2770548 Disease Relevance 0.73 Pain Relevance 0
This was measured with the Nb2 lymphoma cell assay which is an in vitro assay on a specific cell line that specifically assesses the bioactivity of PRL.
PRL Binding (bioactivity) of associated with lymphatic system cancer
6) Confidence 0.36 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770548 Disease Relevance 1.73 Pain Relevance 0
Further, the endocrine and immune systems closely interact (reviewed in [12]), with ACTH, cortisol, prolactin (PRL) and growth hormone (hGH) being most often implicated in the regulation of the immune system.
prolactin Binding (interact) of in immune system
7) Confidence 0.36 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1501038 Disease Relevance 1.03 Pain Relevance 0.52
Further, the endocrine and immune systems closely interact (reviewed in [12]), with ACTH, cortisol, prolactin (PRL) and growth hormone (hGH) being most often implicated in the regulation of the immune system.
PRL Binding (interact) of in immune system
8) Confidence 0.36 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1501038 Disease Relevance 1.03 Pain Relevance 0.52
Other prolactin inhibiting factors of CNS derivation include GABA, somatostatin, acetylcholine and norepinephine; an autocrine regulation is exerted by prolactin through a short loop negative feedback on its own release, by stimulating TIDA cells through prolactin receptors binding, while GH, TGF?
prolactin Binding (binding) of associated with gaba and somatostatin
9) Confidence 0.36 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0 Pain Relevance 0.35
There was also no increase in PTHrP during r-hPRL treatment, an observation that is surprising in light of the association between PTHrP and prolactin in lactating women and women with hyperprolactinemia [20,33,34] and interventional studies in animals [47,48].
prolactin Binding (association) of associated with galactorrhea
10) Confidence 0.35 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC1950489 Disease Relevance 0.48 Pain Relevance 0
Plasma amino acids, prolactin and blood metabolites
prolactin Binding (metabolites) of in blood
11) Confidence 0.34 Published 2010 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2896923 Disease Relevance 0.17 Pain Relevance 0
Blood was sampled at intervals for serum prolactin, growth hormone (GH), and cortisol.
serum prolactin Binding (intervals) of in Blood
12) Confidence 0.29 Published 1987 Journal Psychiatry Res Section Abstract Doc Link 2829259 Disease Relevance 0.09 Pain Relevance 0.51
Stress hormones such as catecholamines (adrenalin, nonadrenaline and dopamine) and the hypothalamic-pituitary-adrenal axis interact with hormones which are responsible for normal ovulatory cycles: i.e., gonadotropin releasing hormone (GnRH), prolactin, LH and FSH.
prolactin Binding (interact) of in pituitary associated with stress, dopamine and catecholamine
13) Confidence 0.21 Published 1992 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 1618356 Disease Relevance 1.39 Pain Relevance 0.20
If the full breast is emptied, prolactin again will bind to the membrane receptors, thus enhancing milk synthesis.
prolactin Binding (bind) of
14) Confidence 0.10 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC2075483 Disease Relevance 0.32 Pain Relevance 0.04
We examined concentrations of follicle-stimulating hormone, luteinizing hormone (LH), estradiol, progesterone, prolactin, and cortisol.
prolactin Spec (examined) Binding (concentrations) of in follicle
15) Confidence 0.09 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC416440 Disease Relevance 1.55 Pain Relevance 0.29
The accumulation of milk in the breast will reduce the binding of prolactin to its membranes.
prolactin Binding (binding) of
16) Confidence 0.07 Published 2007 Journal Int Breastfeed J Section Body Doc Link PMC2075483 Disease Relevance 0.40 Pain Relevance 0.05
Hormonal assay: FSH, LH, Testosterone, TSH and Prolactin (for male with abnormal seminal analysis and suspected endocrine disorder)
Prolactin Binding (assay) of associated with endocrine disease
17) Confidence 0.06 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2844387 Disease Relevance 1.31 Pain Relevance 0.13
In most patients with prolactinomas, treatment with dopamine agonists normalizes prolactin levels, restores gonadal function and fertility, and reduces the size of the tumor.
prolactin Binding (normalizes) of in gonadal associated with dopamine, cancer, prolactinoma and agonist
18) Confidence 0.06 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 1.20 Pain Relevance 0.33
Growth hormone, insulin, glycocorticoids, and prolactin are also implicated, but there is no evidence to support an involvement of these hormones in eyelash growth.17

Prostamides metabolism

prolactin Binding (implicated) of in eyelash
19) Confidence 0.04 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861943 Disease Relevance 0.50 Pain Relevance 0

General Comments

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