INT60224

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Context Info
Confidence 0.02
First Reported 1993
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.36
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

LOC364718 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 16 94.32 High High
agonist 6 88.16 High High
Cholecystokinin 4 75.00 Quite High
Pain 2 62.88 Quite High
Disease Link Frequency Relevance Heat
Pain 2 62.88 Quite High
Panic Disorder 2 61.40 Quite High
Anxiety Disorder 2 60.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An isoleucine in the same position of the human receptor selectively increases affinity for L364718.
L364718 Binding (affinity) of
1) Confidence 0.02 Published 1993 Journal Nature Section Abstract Doc Link 8455720 Disease Relevance 0.17 Pain Relevance 0.55
Substitution of valine 319 with a leucine residue decreases the affinity for L365260 20-fold while concomitantly increasing the affinity for L364718.
L364718 Binding (affinity) of
2) Confidence 0.02 Published 1993 Journal Nature Section Abstract Doc Link 8455720 Disease Relevance 0.19 Pain Relevance 0.55

General Comments

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