INT60228

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Context Info
Confidence 0.34
First Reported 1993
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
articular cartilage 4
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 4 100.00 Very High Very High Very High
Osteoarthritis 52 93.88 High High
cINOD 56 90.72 High High
COX-2 inhibitor 10 78.88 Quite High
Inflammation 12 70.16 Quite High
diclofenac 5 28.40 Quite Low
Pain 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 59 93.88 High High
INFLAMMATION 14 70.16 Quite High
Frailty 2 61.76 Quite High
Arthropathy 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Arrhythmias 2 Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of the articular cartilage showed the naproxen was able to significantly suppress the decrease in proteoglycan content and metalloproteinase activities.
Negative_regulation (suppress) of Negative_regulation (decrease) of metalloproteinase in articular cartilage associated with metalloproteinase
1) Confidence 0.34 Published 1993 Journal Agents Actions Suppl. Section Abstract Doc Link 8456630 Disease Relevance 0.16 Pain Relevance 0.22
However, a different ACLT canine study [15] showed that naproxen was able to suppress significantly the decreases in proteoglycan content and metalloproteinase activities in knee articular cartilage [15].
Negative_regulation (suppress) of Negative_regulation (decreases) of metalloproteinase in articular cartilage associated with metalloproteinase
2) Confidence 0.02 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526565 Disease Relevance 0.46 Pain Relevance 0.41

General Comments

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