INT6025

Context Info Confidence 0.57 First Reported 1981 Last Reported 1992 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.96 Pain Relevance 2.82

cytosol (RIPK2) signal transduction (RIPK2) intracellular (RIPK2) cytoplasm (RIPK2) signal transducer activity (RIPK2)

Anatomy Link Frequency papilla 1 RIPK2 (Homo sapiens)

Pain Link Frequency Relevance Heat Enkephalin 11 100.00 Cholecystokinin 6 100.00 agonist 1 99.72 qutenza 12 99.16 Spinal cord 3 95.52 Chronic pancreatitis 8 94.44 Opioid 1 84.68 substance P 1 83.60 abdominal pain 2 81.52 backache 1 80.00

Disease Link Frequency Relevance Heat Pancreatitis 8 94.44 Abdominal Pain 2 81.52 Low Back Pain 1 80.00 Pain 1 73.44 Natriuresis 1 71.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Intraperitoneal, fourth ventricular or perivagal application of capsaicin attenuated or abolished cholecystokinin (CCK)-induced suppression of food intake.

Negative_regulation (suppression) of CCK associated with qutenza and cholecystokinin

1) Confidence 0.57 Published 1988 Journal Peptides Section Abstract Doc Link 3420015 Disease Relevance 0 Pain Relevance 0.97

Kinetics of hydrolysis of CCK-like peptides indicated a rapid processing of CCK-4 and a slower breakdown of CCK-8 (with a greater resistance of the sulfated form of CCK-8 as compared to the unsulfated peptide).

Negative_regulation (breakdown) of CCK

2) Confidence 0.57 Published 1981 Journal Peptides Section Abstract Doc Link 6283489 Disease Relevance 0 Pain Relevance 0.44

Peptidomimetics as receptors agonists or peptidase inhibitors: a structural approach in the field of enkephalins, ANP and CCK.

Negative_regulation (inhibitors) of CCK associated with agonist and enkephalin

3) Confidence 0.41 Published 1992 Journal Biopolymers Section Title Doc Link 1320419 Disease Relevance 0.07 Pain Relevance 0.53

PPJ was collected from within the main pancreatic duct by endoscopic retrograde catheterization of the papilla after a rapid intravenous injection of secretin and CCK-PZ.

Negative_regulation (injection) of CCK in papilla

4) Confidence 0.41 Published 1982 Journal Gastroenterol. Jpn. Section Abstract Doc Link 6217103 Disease Relevance 0.88 Pain Relevance 0.88

General Comments

This test has worked.