INT60285

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Context Info
Confidence 0.56
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 28
Disease Relevance 21.71
Pain Relevance 8.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Racgap1) transport (Racgap1) intracellular (Racgap1)
embryo development (Racgap1) cytoplasm (Racgap1) signal transduction (Racgap1)
Anatomy Link Frequency
neuronal 3
vesicles 2
cerebellar granule cells 1
liver 1
spinal cord 1
Racgap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 21 99.80 Very High Very High Very High
ischemia 1034 99.56 Very High Very High Very High
Enkephalin 18 99.32 Very High Very High Very High
opioid receptor 102 99.12 Very High Very High Very High
withdrawal 35 99.08 Very High Very High Very High
MU agonist 14 98.74 Very High Very High Very High
Hippocampus 245 98.16 Very High Very High Very High
Spinal cord 344 98.00 Very High Very High Very High
Thalamus 5 97.80 Very High Very High Very High
COX2 7 97.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 233 99.64 Very High Very High Very High
Cv General 4 Under Development 660 99.56 Very High Very High Very High
Urological Neuroanatomy 10 99.48 Very High Very High Very High
Stress 352 99.36 Very High Very High Very High
Injury 63 99.36 Very High Very High Very High
Cancer 134 99.32 Very High Very High Very High
Reperfusion Injury 72 98.68 Very High Very High Very High
Cv Unclassified Under Development 365 98.60 Very High Very High Very High
Metastasis 18 98.60 Very High Very High Very High
Spinal Cord Injury 165 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic morphine (3 days) decreased the low Km GTPase activity of PAG (42), whereas it increased the one of thalamus (99).
Negative_regulation (decreased) of GTPase in thalamus associated with urological neuroanatomy, thalamus and morphine
1) Confidence 0.56 Published 1993 Journal Life Sci. Section Abstract Doc Link 8464330 Disease Relevance 0.46 Pain Relevance 0.74
In membranes from Rat-1 fibroblasts transfected to express the murine delta-opioid receptor stably (clone D2 cells), the delta-opioid agonist [D-Ser2-Leu5-Thr6]enkephalin (DSLET) stimulated high affinity GTPase activity, which was inhibited by peptides that are derived from the proximal (i3.1) and the distal portions (i3.3) of the third intracellular loop with IC50 values of 15 +/- 5 and 50 +/- 4 microM, respectively.
Negative_regulation (inhibited) of GTPase in proximal associated with mu agonist, enkephalin and opioid receptor
2) Confidence 0.07 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8863845 Disease Relevance 0 Pain Relevance 0.47
Interestingly, targeted inhibition of Rac1 GTPase via a dominant negative approach has been shown to similarly exert anti-oxidative stress effects against ischemia/reperfusion injury in the liver [26].
Negative_regulation (inhibition) of GTPase in liver associated with stress, reperfusion injury and ischemia
3) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.42 Pain Relevance 0.34
We next examined the effect of Rac GTPase inhibition upon oxidative stress damage in the hippocampal CA1 region following GCI.
Spec (examined) Negative_regulation (inhibition) of Rac GTPase associated with stress and ischemia
4) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.20 Pain Relevance 0.43
Functional outcome of Rac GTPase inhibition on learning and spatial memory in the hippocampal CA1 region
Negative_regulation (inhibition) of Rac GTPase
5) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.07 Pain Relevance 0.30
In addition, Morris Water maze testing revealed that Rac GTPase inhibition after ischemic injury significantly improved hippocampal-dependent memory and cognitive spatial abilities at 7–9 d post reperfusion as compared to vehicle-treated animals.


Negative_regulation (inhibition) of Rac GTPase associated with cognitive disorder and injury
6) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935374 Disease Relevance 1.41 Pain Relevance 0.35
Furthermore, deletion of Rac1 GTPase in mouse rod photoreceptors via a Cre/Lox approach has been shown to strongly protect rod photoreceptors against photo-oxidative stress [27].
Negative_regulation (deletion) of GTPase in photoreceptors associated with stress
7) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.40 Pain Relevance 0.33
The elevation of Rac GTPase activation appears to contribute to the pathology following ischemic stress as evidenced by our finding that administration of a Rac GTPase inhibitor, NSC23766 or Rac1 antisense oligonucleotides [7] attenuated apoptotic neuronal cell death following GCI.
Negative_regulation (inhibitor) of Rac GTPase in neuronal associated with stress, ischemia, apoptosis and death
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.16 Pain Relevance 0.24
Rac GTPase inhibition through administration of NSC23766 resulted in an almost complete attenuation of the oxidative stress damage as indicated by a strong attenuation of 4-HNE, 8-OHdG and p-H2AX immunostaining in the hippocampal CA1 region as compared to saline (ischemia) controls.


Negative_regulation (inhibition) of Rac GTPase associated with stress and ischemia
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.19 Pain Relevance 0.35
Figure 1 shows the results of the effect of administration of a Rac GTPase inhibitor, NSC23766 upon Rac1 GTPase activity (Fig. 1A) and neuronal cell survival (Fig. 1B&C) in the hippocampal CA1 region.
Negative_regulation (inhibitor) of Rac GTPase in neuronal
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.17 Pain Relevance 0.14
Furthermore, saline treatment had no effect upon Rac1 activity at 3 h post-reperfusion, whereas treatment with the Rac GTPase inhibitor, NSC23766 resulted in ?
Negative_regulation (inhibitor) of Rac GTPase
11) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.34 Pain Relevance 0.18
Intriguingly, icv administration of the Rac GTPase inhibitor (NSC23766) strongly protected the hippocampal CA1 neurons from neuronal degeneration and apoptotic cell death, as evidenced by preserved NeuN neuronal staining and strongly attenuated Fluoro-Jade B and TUNEL staining in NSC23766-treated animals as compared to saline controls (Figure 1B).
Negative_regulation (inhibitor) of Rac GTPase in apoptotic cell associated with apoptosis and death
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 0.79 Pain Relevance 0.26
In addition, the current study revealed that neuronal degeneration in the hippocampal CA1 region was also markedly inhibited by the pretreatment of the Rac GTPase inhibitor following GCI, suggesting an important role of Rac GTPase activation in delayed neuronal degeneration following ischemia/reperfusion injury.
Negative_regulation (inhibitor) of Rac GTPase in neuronal associated with reperfusion injury and ischemia
13) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935374 Disease Relevance 1.22 Pain Relevance 0.29
Administration of a Rac GTPase inhibitor (NSC23766) 15 min before cerebral ischemia significantly attenuated NADPH oxidase activation and O2?
Negative_regulation (inhibitor) of Rac GTPase associated with cv general 4 under development and ischemia
14) Confidence 0.03 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935374 Disease Relevance 1.04 Pain Relevance 0.33
-secretases and through the isoprenylation of GTPase, which takes part in secretases assembly to the APP, reduce ?
Negative_regulation (isoprenylation) of GTPase
15) Confidence 0.02 Published 2009 Journal The Open Neurology Journal Section Body Doc Link PMC2684708 Disease Relevance 0.52 Pain Relevance 0.31
To assess if inhibition of geranyl-geranylation by ZOL impairs the biological activity of RhoA GTPase, we studied the LPA-induced formation of stress fibers.
Negative_regulation (impairs) of GTPase associated with stress
16) Confidence 0.01 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1434759 Disease Relevance 0.27 Pain Relevance 0
In NG108-15 cell membranes, acidic pretreatment increases opioid receptor-mediated inhibition of adenylyl cyclase by impairing GTPase activity (Selley et al 1993).
Negative_regulation (impairing) of GTPase in NG108-15 associated with opioid receptor
17) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.62 Pain Relevance 1.73
Simultaneous suppression of Rac and Rho GTPase activities resulted in strong enhancement of cell survival both in the intact spinal cord after transplantation and in the culture system.
Negative_regulation (suppression) of GTPase in spinal cord associated with spinal cord
18) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.81 Pain Relevance 0.27
Furthermore, suppression of both Rho and Rac GTPase activity by DN constructs resulted in strong inhibition of a mitochondrial apoptotic cascade induced by staurosporine.
Negative_regulation (suppression) of GTPase associated with apoptosis
19) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 1.06 Pain Relevance 0.12
However, in the case of cerebellar granule cells, down-regulation of Rac GTPase induces apoptosis through the c-Jun-dependent induction of the BH3-only protein Bim and the subsequent activation of a mitochondrial apoptotic cascade [22].
Negative_regulation (regulation) of GTPase in cerebellar granule cells associated with apoptosis
20) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 1.03 Pain Relevance 0.07

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