INT60286

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Context Info
Confidence 0.65
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.14
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PKLR) small molecule metabolic process (PKLR) carbohydrate metabolic process (PKLR)
Anatomy Link Frequency
Endothelial cells 1
PKLR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 99.92 Very High Very High Very High
Hsan 8 93.80 High High
Paracetamol 4 87.80 High High
Calcium channel 1 75.00 Quite High
Inflammatory response 8 67.44 Quite High
conotoxin 1 65.80 Quite High
Nerve growth factor 21 60.16 Quite High
Catecholamine 1 60.00 Quite High
opiate 3 57.68 Quite High
Dopamine 1 42.80 Quite Low
Disease Link Frequency Relevance Heat
Cancer 411 99.34 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 8 93.80 High High
Stress 2 89.60 High High
Cold Sores 734 88.84 High High
Poisoning 2 88.32 High High
Infection 135 85.88 High High
Syndrome 3 85.84 High High
Uniparental Disomy 2 85.68 High High
Injury 7 77.44 Quite High
INFLAMMATION 34 67.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A splice mutation and a missense mutation were detected in the TRKA and PKLR genes from the homozygous proband, respectively.
Gene_expression (detected) of PKLR
1) Confidence 0.65 Published 2001 Journal Hum. Mutat. Section Abstract Doc Link 11668614 Disease Relevance 0.86 Pain Relevance 0.56
Endothelial cells blockade obtained by the addition of large excess (30 uM) of formaldehyde-treated serum albumin to the perfusion fluid does not affect the hepatic clearance of RPK (the half-lives of hepatic uptake were 15.5 +/- 1.0 min in the absence versus 16.5 +/- 1.4 min in the presence of the treated protein, p > 0.05).
Gene_expression (clearance) of RPK in Endothelial cells
2) Confidence 0.22 Published 1993 Journal Life Sci. Section Abstract Doc Link 8464345 Disease Relevance 0.32 Pain Relevance 0.28
Mutations to this sequence, by insertion of a methionine preceding the N-terminal alanine, substitution of the N-terminal alanine with a methionine [10] or deletion of the first two amino acids [11], produce PK receptor (PKR) antagonists.
Gene_expression (produce) of PKR associated with antagonist
3) Confidence 0.13 Published 2007 Journal Trends in Endocrinology and Metabolism Section Body Doc Link PMC2694302 Disease Relevance 0 Pain Relevance 0.05
This effect is mediated through the cellular PKR kinase, which phosphorylates the translation initiation factor eIF2?
Gene_expression (kinase) of PKR
4) Confidence 0.11 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.56 Pain Relevance 0
Tumour cells often display an impaired PKR pathway and/or elevated levels of eIF2?
Gene_expression (pathway) of PKR associated with cancer
5) Confidence 0.11 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.41 Pain Relevance 0
L-Type channels and N-type channels are also expressed, but to a considerably minor extent (around 20% each).
Gene_expression (expressed) of L-Type
6) Confidence 0.03 Published 1998 Journal Pflugers Arch. Section Abstract Doc Link 9716702 Disease Relevance 0 Pain Relevance 0.16

General Comments

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