INT60289

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Context Info
Confidence 0.21
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.75
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PKLR) small molecule metabolic process (PKLR) carbohydrate metabolic process (PKLR)
Anatomy Link Frequency
livers 1
PKLR (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 4 100.00 Very High Very High Very High
Inflammatory response 4 84.48 Quite High
cytokine 42 84.08 Quite High
Inflammation 14 75.88 Quite High
sodium channel 2 72.08 Quite High
Action potential 1 48.16 Quite Low
cocaine 1 26.16 Quite Low
Pain 17 25.00 Low Low
Angina 1 25.00 Low Low
imagery 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Arrhythmia 3 96.16 Very High Very High Very High
Necrosis 8 92.96 High High
Cold Sores 367 91.92 High High
Congenital Anomalies 2 90.08 High High
Phlebotomus Fever 4 84.32 Quite High
INFLAMMATION 18 84.12 Quite High
Arrhythmias 2 Under Development 1 83.44 Quite High
Myocardial Infarction 1 80.08 Quite High
Injury 4 78.88 Quite High
Poisoning 2 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prevalence of the Brugada-type ECG and its natural history are still unclear.
Negative_regulation (prevalence) of Brugada-type ECG
1) Confidence 0.21 Published 2010 Journal Int. J. Cardiol. Section Abstract Doc Link 19117622 Disease Relevance 0.39 Pain Relevance 0.04
On the other hand the RPK clearance by the livers of rats previously intoxicated with acetaminophen was markedly deficient (the half-life of hepatic uptake was 39.2 +/- 3.2 min).
Negative_regulation (deficient) of RPK in livers associated with paracetamol
2) Confidence 0.14 Published 1993 Journal Life Sci. Section Abstract Doc Link 8464345 Disease Relevance 0.29 Pain Relevance 0.35
Together with the data showing that NSs suppresses cellular transcription, these studies on the downregulation of PKR highlight different strategies of NSs to prevent the innate antiviral host responses.
Negative_regulation (downregulation) of PKR
3) Confidence 0.08 Published 2010 Journal Veterinary Research Section Body Doc Link PMC2896810 Disease Relevance 0.23 Pain Relevance 0
It has been demonstrated, for the first time, that vhs can block the induction of DC activation by TLR-independent pathways [316]; (3) inhibition of PKR by US11 [317] and ?
Negative_regulation (inhibition) of PKR
4) Confidence 0.07 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.60 Pain Relevance 0.15
Very recently, a novel function of NSs was described simultaneously by Ikegami et al. [127, 128] and Habjan et al. [109]: NSs promotes post transcriptional downregulation of dsRNA-dependent protein kinase (PKR) and therefore prevents phosphorylation of eIF2?
Negative_regulation (downregulation) of PKR
5) Confidence 0.06 Published 2010 Journal Veterinary Research Section Body Doc Link PMC2896810 Disease Relevance 0.23 Pain Relevance 0

General Comments

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