INT60291

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Context Info
Confidence 0.19
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.99
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (SOAT1) transferase activity, transferring acyl groups (SOAT1)
Anatomy Link Frequency
Blood 1
immune cells 1
SOAT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 128 100.00 Very High Very High Very High
cytokine 64 100.00 Very High Very High Very High
Inflammatory mediators 7 98.80 Very High Very High Very High
psoriasis 1 95.72 Very High Very High Very High
rheumatoid arthritis 4 95.28 Very High Very High Very High
Multiple sclerosis 4 94.40 High High
Pain 4 90.80 High High
Inflammatory response 17 85.04 High High
cINOD 6 84.48 Quite High
anesthesia 1 63.64 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 158 100.00 Very High Very High Very High
Autoimmune Disease 6 99.92 Very High Very High Very High
Alzheimer's Dementia 4 97.72 Very High Very High Very High
Inflammatory Bowel Disease 40 97.00 Very High Very High Very High
Psoriasis 1 95.72 Very High Very High Very High
Diabetes Mellitus 46 95.28 Very High Very High Very High
Rheumatoid Arthritis 4 95.28 Very High Very High Very High
Adhesions 12 94.88 High High
Demyelinating Disease 4 94.40 High High
Disorder Of Lipid Metabolism 6 94.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: In the 24 patients with abnormal routine NCS/nEMG, NC-stat EDX was abnormal in 22.
Regulation (abnormal) of NC-stat EDX
1) Confidence 0.19 Published 2008 Journal Acta Neurol. Scand. Section Body Doc Link 18355396 Disease Relevance 0.08 Pain Relevance 0
Regulation of excess intracellular free cholesterol through the activity of acyl-CoA:cholesterol acyltransferase, (ACAT)
Regulation (Regulation) of cholesterol acyltransferase
2) Confidence 0.07 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.30 Pain Relevance 0.07
STAT regulated genes include inducible nitric oxide synthase (iNOS) [38], and CXCL10 [30] among others.
Regulation (regulated) of STAT
3) Confidence 0.02 Published 2010 Journal BMC Chem Biol Section Body Doc Link PMC2881005 Disease Relevance 0.46 Pain Relevance 0.16
Deregulated STAT activity and upregulation of certain antioxidant -genes seem to play a role in HDACi resistance.
Regulation (Deregulated) of STAT
4) Confidence 0.01 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.19 Pain Relevance 0
Blood variables having the most significant effect on the Coulter-Stat-Crit difference (bias) were protein, Cl, and Na.
Regulation (effect) of Stat-Crit in Blood
5) Confidence 0.01 Published 1993 Journal Anesth. Analg. Section Abstract Doc Link 8466026 Disease Relevance 0 Pain Relevance 0.06
STAT signaling is tightly regulated by its negative regulators, suppressors of cytokine signaling (SOCS), and is controlled by STAT phosphorylation [37].
Regulation (regulated) of STAT associated with cytokine
6) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.24 Pain Relevance 0.17
Accordingly, modulation of the JAK/STAT signaling pathway may not only prove to be an effective means for suppressing microglial-mediated inflammation but also an important target for neurodegenerative disease therapy.
Regulation (modulation) of STAT associated with inflammation and neurodegenerative disease
7) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 0.56 Pain Relevance 0.22
Curcumin inhibits these autoimmune diseases by regulating inflammatory cytokines such as IL-1beta, IL-6, IL-12, TNF-alpha and IFN-gamma and associated JAK-STAT, AP-1, and NF-kappaB signaling pathways in immune cells.
Regulation (regulating) of JAK-STAT in immune cells associated with autoimmune disease, inflammation and cytokine
8) Confidence 0.01 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17569223 Disease Relevance 1.88 Pain Relevance 0.48
Other high-ranking but nonsignificant categories included regulation of actin cytoskeleton, neuroactive lig-and–receptor interaction, Jak-STAT signaling, axon guidance, ABC transporters, peroxisome proliferator–activated receptor (PPAR) signaling pathway, and type 1 diabetes mellitus.
Regulation (regulation) of Jak-STAT associated with diabetes mellitus
9) Confidence 0.01 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.28 Pain Relevance 0

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