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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.86
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Mention Frequency
liver 1
lymphocytes 1

Pain Term Frequency Confidence Heat
Paracetamol 22 99.82 Very High Very High Very High
alcohol 92 99.74 Very High Very High Very High
fibrosis 19 85.56 High High
cytokine 6 75.68 Quite High
Inflammation 17 25.76 Quite Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Catechol-O-methyltransferase 1 5.00 Very Low Very Low Very Low
gABA 7 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
monoamine 1 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Hepatotoxicity 11 98.80 Very High Very High Very High
Stress 7 94.12 High High
Injury 23 92.40 High High
Cancer 10 91.60 High High
Necrosis 2 91.12 High High
Cirrhosis 37 86.12 High High
Toxicity 5 83.52 Quite High
Diabetes Mellitus 13 83.24 Quite High
Alcoholic Fatty Liver 2 81.76 Quite High
Fatty Liver 6 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that in rat liver there is only slight perivenous zonation of APAP conjugation and suggest that zone-specific APAP activation, mediated by the regional expression of ethanol-inducible cytochrome P450 2E1, is responsible for the characteristic centrilobular liver damage elicited by APAP.
Positive_regulation (inducible) of cytochrome P450 2E1 in liver associated with paracetamol and hepatotoxicity
1) Confidence 0.67 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8466546 Disease Relevance 0.26 Pain Relevance 0.80
Chronic alcohol consumption induces cytochrome P450 2E1, a microsomal enzyme that metabolizes alcohol at high concentrations and also metabolizes medications such as acetaminophen and protease inhibitors.
Positive_regulation (induces) of cytochrome P450 2E1 associated with paracetamol and alcohol
2) Confidence 0.67 Published 2007 Journal Hepatology Section Abstract Doc Link 18046720 Disease Relevance 0.67 Pain Relevance 0.69
The pre-intake of these compounds also significantly retarded subsequent acetaminophen-induced increase of cytochrome P450 2E1 activity (P < 0.05).
Positive_regulation (increase) of cytochrome P450 2E1 associated with paracetamol
3) Confidence 0.45 Published 2009 Journal J. Food Sci. Section Abstract Doc Link 19799668 Disease Relevance 0.56 Pain Relevance 0.69
One of our novel findings is that lymphocytes from arsenic-exposed individuals had higher levels of cytochrome P450 2E1 (CYP2E1), which metabolizes and bioactivates a number of chemicals by forming epoxides, including benzene, vinyl chloride, 1,1-dichloroethylene, trichloroethylene, 1,3-butadiene, acrylonitrile, and acrylamide, and metabolizes acetaminophen (Ghanayem 2007).
Positive_regulation (levels) of cytochrome P450 2E1 in lymphocytes associated with paracetamol
4) Confidence 0.45 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.48 Pain Relevance 0.09
A central pathway appears to be the induction of cytochrome P450 2E1.
Positive_regulation (induction) of cytochrome P450 2E1
5) Confidence 0.45 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2898022 Disease Relevance 0.89 Pain Relevance 0.21

General Comments

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