INT60328

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Context Info
Confidence 0.29
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.84
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b, Tnf) extracellular region (Il1b, Tnf) signal transduction (Tnf)
aging (Il1b) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
NRK-49F 1
Il1b (Rattus norvegicus)
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 4 98.92 Very High Very High Very High
Inflammation 6 97.80 Very High Very High Very High
dexamethasone 2 87.28 High High
chemokine 1 75.00 Quite High
Snapping jaw 1 66.28 Quite High
cINOD 1 56.96 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 11 98.36 Very High Very High Very High
INFLAMMATION 7 97.80 Very High Very High Very High
Skin Cancer 1 90.68 High High
Necrosis 2 84.96 Quite High
Cancer 2 84.60 Quite High
Temporomandibular Joint Syndrome 1 66.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 beta was a stronger stimulator than TNF-alpha, and addition of both the cytokines into the NRK-49F cell culture caused an additive stimulation for rat gro/CINC production.
IL-1 beta Positive_regulation (stimulator) of TNF-alpha in NRK-49F associated with cytokine
1) Confidence 0.29 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8471066 Disease Relevance 0.58 Pain Relevance 0.48
Application of CTS for only 1 or 2h during a 24h incubation with IL-1beta was sufficient to inhibit IL-1beta-induced upregulation of TNF-alpha, TNFR2, and iNOS.
IL-1beta-induced Positive_regulation (upregulation) of TNF-alpha associated with sprains and strains
2) Confidence 0.08 Published 2007 Journal J Biomech Section Abstract Doc Link 17049356 Disease Relevance 1.26 Pain Relevance 0.14

General Comments

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