INT60334

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Context Info
Confidence 0.26
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.15
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAV) plasma membrane (ITGAV)
Anatomy Link Frequency
osteoclasts 2
leucocyte 1
erythrocyte 1
ITGAV (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 160 98.04 Very High Very High Very High
Osteoarthritis 27 97.76 Very High Very High Very High
antagonist 8 77.64 Quite High
Pain 21 51.48 Quite High
Arthritis 123 50.00 Quite Low
Inflammation 14 26.32 Quite Low
spinal inflammation 17 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 160 98.04 Very High Very High Very High
Osteoarthritis 27 97.76 Very High Very High Very High
Adhesions 82 95.00 High High
Metastasis 29 93.08 High High
Hypercalcemia 8 89.76 High High
Sickle Cell Anemia 2 75.00 Quite High
Recurrence 28 70.56 Quite High
Pain 20 51.48 Quite High
Cancer 71 50.72 Quite High
Seronegative Spondarthritis 117 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
3 (CD51/CD61, integrin expressed on endothelial cells, fibroblasts, osteoclasts, etc., clone LM609; Chemicon), anti-E-selectin (CD62E, endothelial leucocyte adhesion molecule 1, clone 1.2B6), anti-ICAM-1 (CD54, intercellular adhesion molecule [ICAM]-1, clone 6.5B5), anti-VCAM-1 (CD106, vascular cell adhesion molecule [VCAM]-1, clone 1.4C3), the rabbit polyclonal anti-L-citrulline antibody (citrullinated peptides; Biogenesis, Poole, UK), and Mab-12A (detecting major histocompatibility complex [MHC] class II–human cartilage [HC] gp39 peptide complexes; NV Organon, Oss, The Netherlands) [18,21].
Gene_expression (expressed) of CD51 in leucocyte associated with adhesions
1) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 0.28 Pain Relevance 0
Incubation of MEC with OKM5 or anti-alpha v monoclonal antibodies inhibited TSP-mediated sickle erythrocyte adherence more than 95%.
Gene_expression (Incubation) of anti-alpha v in erythrocyte
2) Confidence 0.11 Published 1993 Journal Blood Section Abstract Doc Link 8471771 Disease Relevance 0.13 Pain Relevance 0.05
Multinucleated cells isolated from GCTB expressed the antigenic phenotype of osteoclasts, being TRAP and CD51 positive and CD14 negative [3,19].
Gene_expression (expressed) of CD51 in osteoclasts
3) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2940802 Disease Relevance 0.97 Pain Relevance 0.05
Multinucleated cells isolated from GCTB expressed the antigenic phenotype of osteoclasts, being TRAP and CD51 positive and CD14 negative [3,19].
Neg (negative) Gene_expression (positive) of CD51 in osteoclasts
4) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2940802 Disease Relevance 0.84 Pain Relevance 0
Moreover, Planctomycetes and the related Verrucobacteria make proteins homologous to those of the eukaryotic cytoskeleton, such as integrin alpha-V, tubulin, actin and dynamin that could very well be of protoeukaryotic rather than prokaryotic origin [27,50,76].
Gene_expression (make) of integrin alpha-V
5) Confidence 0.04 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0 Pain Relevance 0
The expression of several integrin-receptor subunits is also increased in situ.
Gene_expression (expression) of integrin-receptor
6) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991025 Disease Relevance 0.94 Pain Relevance 0.41

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