INT60339

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Context Info
Confidence 0.66
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.04
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP21A2) endoplasmic reticulum (CYP21A2)
Anatomy Link Frequency
Neuronal 1
hindgut 1
neural 1
CYP21A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 62 100.00 Very High Very High Very High
noradrenaline 26 100.00 Very High Very High Very High
Dopamine 16 100.00 Very High Very High Very High
Catecholamine 1 100.00 Very High Very High Very High
cytokine 2 99.46 Very High Very High Very High
gABA 1 99.04 Very High Very High Very High
monoamine 17 94.96 High High
Migraine 6 93.52 High High
depression 55 93.32 High High
Calcium channel 4 90.20 High High
Disease Link Frequency Relevance Heat
Carcinoid 18 99.96 Very High Very High Very High
Adrenal Cancer 137 99.52 Very High Very High Very High
Neuroendocrine Cancer 22 98.64 Very High Very High Very High
Headache 9 93.52 High High
Depression 62 93.32 High High
Cancer 29 90.56 High High
Depressive Disorder 3 90.36 High High
Adhesions 3 89.44 High High
Disease 30 87.00 High High
Targeted Disruption 1 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In one study, among 123 women with NCAH confirmed by molecular CYP21A2 analysis, mean basal 17-OHP and mean ACTH-stimulated 17-OHP concentrations were 1300 ± 1420?
Gene_expression (analysis) of CYP21A2 associated with adrenal cancer
1) Confidence 0.66 Published 2010 Journal International Journal of Pediatric Endocrinology Section Body Doc Link PMC2910408 Disease Relevance 0.85 Pain Relevance 0
We were able to reveal immunoreactivity for enzymes involved in the synthesis of the catecholamines dopamine and noradrenaline (tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine-beta-hydroxylase), for the indolamine 5-hydroxytryptamine (serotonin), as well as for a number of well-known neuronal markers such as the neurofilament protein 200, synaptophysin, chromogranin A + B, the neural cell-adhesion molecule (N-CAM), the microtubule-associated protein (MAP-2), and the calcium-binding proteins: S-100, calbindin and parvalbumin.
Gene_expression (synthesis) of hydroxylase in neural associated with dopamine, catecholamine, noradrenaline, serotonin and adhesions
2) Confidence 0.08 Published 1993 Journal Cell Tissue Res. Section Abstract Doc Link 8472301 Disease Relevance 0.09 Pain Relevance 0.25
However, in hindgut carcinoids, hydroxylase and decarboxylase are absent and no serotonin is produced.
Neg (absent) Gene_expression (absent) of hydroxylase in hindgut associated with carcinoid and serotonin
3) Confidence 0.04 Published 2006 Journal World J Surg Oncol Section Body Doc Link PMC1524962 Disease Relevance 1.12 Pain Relevance 0.46
Noradrenaline depletion may be due to inhibition of tyrosine hydroxylase (see Figure 1), whereas reduced synthesis of serotonin may be due to depletion of dietary tryptophan or mutations of tryptophan hydroxylase.7,12 Given that reduced serotonin levels do not cause depression in all people, it is unclear if decreased serotonin synthesis is a cause or consequence of depression.9
Gene_expression (tyrosine) of hydroxylase associated with depression, noradrenaline and serotonin
4) Confidence 0.03 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 1.33 Pain Relevance 0.96
However, our results raise the question whether the 20% residual activity of TPH2-R441H might simply reflect a low intrinsic 5-HT synthesis capacity of PC12 cells, either due to a low endogenous TPH expression or the known substrate promiscuity of tyrosine hydroxylase [2], which is highly expressed in these catecholaminergic cells.
Gene_expression (expressed) of hydroxylase
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0 Pain Relevance 0.11
However, our results raise the question whether the 20% residual activity of TPH2-R441H might simply reflect a low intrinsic 5-HT synthesis capacity of PC12 cells, either due to a low endogenous TPH expression or the known substrate promiscuity of tyrosine hydroxylase [2], which is highly expressed in these catecholaminergic cells.
Gene_expression (expression) of hydroxylase
6) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813293 Disease Relevance 0 Pain Relevance 0.11
Induced cells with Neuronal Progenitor Basal Medium (NPBM medium) or Neurobasal added with a mix cytokines, demonstrate an increased expression of Tyrosine Hydroxylase (TH), MAP-2, NF, NeuN, GABA, nestin and GFAP [14,16].
Gene_expression (expression) of Hydroxylase in Neuronal associated with gaba and cytokine
7) Confidence 0.01 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2358905 Disease Relevance 0.07 Pain Relevance 0.17
The UNC-2/transforming growth factor-beta pathway identified regulates the expression of a gene encoding the rate-limiting enzyme for serotonin synthesis, tryptophan hydroxylase.
Gene_expression (expression) of hydroxylase associated with serotonin
8) Confidence 0.01 Published 2006 Journal Headache Section Abstract Doc Link 16927961 Disease Relevance 0.58 Pain Relevance 0.71

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