INT6034

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Context Info
Confidence 0.47
First Reported 1980
Last Reported 2010
Negated 11
Speculated 3
Reported most in Abstract
Documents 115
Total Number 118
Disease Relevance 17.48
Pain Relevance 51.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gabrg1) plasma membrane (Gabrg1)
Anatomy Link Frequency
ileum 3
brain 3
TM3 3
neuron 3
synapse 2
Gabrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 1832 100.00 Very High Very High Very High
GABAergic 690 100.00 Very High Very High Very High
Dopamine 498 100.00 Very High Very High Very High
Neurotransmitter 360 100.00 Very High Very High Very High
agonist 309 100.00 Very High Very High Very High
Glutamate 291 100.00 Very High Very High Very High
Pain 221 100.00 Very High Very High Very High
Spinal cord 156 100.00 Very High Very High Very High
GABA receptor 124 100.00 Very High Very High Very High
Enkephalin 92 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 46 99.48 Very High Very High Very High
Anxiety Disorder 282 99.44 Very High Very High Very High
Targeted Disruption 273 98.96 Very High Very High Very High
Urological Neuroanatomy 3 98.64 Very High Very High Very High
Disease 71 98.20 Very High Very High Very High
Nociception 60 98.08 Very High Very High Very High
Stroke 2 98.04 Very High Very High Very High
Neurodegenerative Disease 66 98.00 Very High Very High Very High
Neuropathic Pain 123 97.72 Very High Very High Very High
Convulsion 178 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pharmacological studies showed that muscimol binds selectively to GABAA receptors, which are located only on postsynaptic sites [19], [20].
GABAA Binding (binds) of
1) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614467 Disease Relevance 0 Pain Relevance 0
However, high concentrations of naloxone (0.1-1 mM) were required, suggesting that naloxone has a low affinity for the GABA receptor.
GABA Binding (affinity) of associated with gaba receptor and narcan
2) Confidence 0.46 Published 1980 Journal Brain Res. Section Abstract Doc Link 6250670 Disease Relevance 0.29 Pain Relevance 1.60
Interaction of the neurotoxic pesticides ivermectin and lindane with the enteric GABAA receptor-ionophore complex in the guinea-pig.
GABAA Binding (Interaction) of
3) Confidence 0.39 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 7687958 Disease Relevance 0.07 Pain Relevance 0.37
These observations indicate that 5-AVA interacts with both GABAA and GABAB receptors in guinea-pig ileum.
GABAA Binding (interacts) of in ileum
4) Confidence 0.38 Published 1985 Journal J Auton Pharmacol Section Abstract Doc Link 2985620 Disease Relevance 0 Pain Relevance 0.21
5-Aminovaleric acid interactions with GABAA and GABAB receptors in guinea-pig ileum.
GABAA Binding (interactions) of in ileum
5) Confidence 0.38 Published 1985 Journal J Auton Pharmacol Section Title Doc Link 2985620 Disease Relevance 0 Pain Relevance 0.19
These results indicate that chronic morphine but not naltrexone enhances benzodiazepine binding and GABAA receptor function, perhaps by an action at opioid receptors.
GABAA receptor Binding (binding) of associated with opioid receptor and morphine
6) Confidence 0.37 Published 1990 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 1697078 Disease Relevance 0 Pain Relevance 0.81
Chronic morphine administration augments benzodiazepine binding and GABAA receptor function.
GABAA receptor Binding (binding) of associated with morphine
7) Confidence 0.37 Published 1990 Journal Psychopharmacology (Berl.) Section Title Doc Link 1697078 Disease Relevance 0 Pain Relevance 0.86
This profile of action is similar to that of bicuculline, suggesting that lidocaine may bind to the GABA recognition site and to another site in the GABA-ionophore receptor complex.
GABA recognition site Binding (bind) of associated with gaba and lidocaine
8) Confidence 0.37 Published 1988 Journal Neurol. Res. Section Abstract Doc Link 2905779 Disease Relevance 0.17 Pain Relevance 0.68
3 (Asn256Met) subunit, being partly related with the GABAA receptor ?
GABAA Binding (receptor) of
9) Confidence 0.36 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2908224 Disease Relevance 0.47 Pain Relevance 0.25
1 subunit, GABA-A receptor ?
GABA-A Binding (receptor) of associated with gaba
10) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC2072938 Disease Relevance 0.11 Pain Relevance 0.35
P.), a specific antagonist for benzodiazepine sites associated with GABAA receptors. 2) Bicuculline (2, 4 mg/kg, I.
GABAA Binding (associated) of associated with antagonist
11) Confidence 0.36 Published 2008 Journal Planta Med. Section Abstract Doc Link 18612941 Disease Relevance 0.74 Pain Relevance 0.42
GABAA, NMDA and cannabinoid receptor signalling
GABAA Binding (cannabinoid receptor) of associated with cannabinoid receptor
12) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.60 Pain Relevance 0.22
P. and oral administration of chrysin produced a significant hyperalgesic effect in the tail-immersion test and that the hyperalgesic effect of chrysin may be associated with GABAA receptors.
GABAA Binding (associated) of in tail associated with hyperalgesia
13) Confidence 0.36 Published 2008 Journal Planta Med. Section Abstract Doc Link 18612941 Disease Relevance 0.70 Pain Relevance 0.36
2 subunit, GABA-A receptor ?
GABA-A Binding (receptor) of associated with gaba
14) Confidence 0.36 Published 2007 Journal Mol Pain Section Body Doc Link PMC2072938 Disease Relevance 0.11 Pain Relevance 0.35
Chronic treatment with diazepam has been shown to alter GABAA receptor affinity for the agonist GABA and some BDZ binding characteristics (Tietz et al 1989; Wu et al 1994).
GABAA receptor Binding (affinity) of associated with gaba and agonist
15) Confidence 0.36 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2526378 Disease Relevance 0.27 Pain Relevance 0.24
These observations suggest an interaction between glycine and GABA receptors during the regulation of antinociception.


GABA Binding (interaction) of
16) Confidence 0.36 Published 2010 Journal Acta Pharmacol. Sin. Section Body Doc Link 20686515 Disease Relevance 0 Pain Relevance 0
Despite its structural similarity to GABA, it does not bind GABAA or GABAB receptors and the mechanism, especially of its analgesic action, has remained elusive.
GABAA Neg (not) Binding (bind) of associated with gaba and analgesic
17) Confidence 0.35 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 14996552 Disease Relevance 0.27 Pain Relevance 0.76
The findings support the potential value of the mouse staircase paradigm for demonstrating behaviorally relevant anxiolysis of test compounds shown to interact in vitro with the GABA(A) receptor complex.
GABA Binding (interact) of associated with gaba and anxiety disorder
18) Confidence 0.35 Published 2001 Journal Brain Res. Section Abstract Doc Link 11368960 Disease Relevance 0.10 Pain Relevance 0.50
Therefore, we investigated the affinity of GABA(B) receptors for the antagonist CGP55845A in wv/wv and +/+ hippocampi.
GABA Binding (affinity) of associated with gaba and antagonist
19) Confidence 0.35 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10670420 Disease Relevance 0 Pain Relevance 0.64
However, it is interesting that SPS may also arise in individuals with autoantibodies to gephyrin, a cytosolic protein concentrated at the postsynaptic membrane of inhibitory synapses where it is associated with GABAA receptors [42].
GABAA Binding (associated) of in synapses associated with syndrome
20) Confidence 0.35 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 1.27 Pain Relevance 0.35

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