INT60388

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Context Info
Confidence 0.07
First Reported 1993
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 90
Total Number 98
Disease Relevance 19.18
Pain Relevance 41.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Helt) nucleus (Helt) DNA binding (Helt)
Anatomy Link Frequency
neurons 27
epithelium 16
pyramidal neurons 7
synapses 7
interneurons 5
Helt (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 1841 100.00 Very High Very High Very High
Pyramidal cell 968 100.00 Very High Very High Very High
amygdala 645 100.00 Very High Very High Very High
Locus ceruleus 40 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
Cholecystokinin 6 99.98 Very High Very High Very High
gABA 1971 99.82 Very High Very High Very High
Anterior cingulate cortex 1128 99.78 Very High Very High Very High
nociceptor 4 99.72 Very High Very High Very High
Glutamate 329 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 1632 99.68 Very High Very High Very High
Sprains And Strains 238 99.28 Very High Very High Very High
Cytomegalovirus Infection 3 98.88 Very High Very High Very High
Depression 42 97.38 Very High Very High Very High
Anxiety Disorder 186 97.16 Very High Very High Very High
Asthma 96 97.10 Very High Very High Very High
Autism 2 97.08 Very High Very High Very High
Stroke 56 97.00 Very High Very High Very High
Schizophrenia 5 96.76 Very High Very High Very High
Manic Depressive Disorder 1 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results provide direct morphological evidence that a subset of GABAergic neurons in the spinal trigeminal system was activated during tooth pulp stimulation.
Gene_expression (neurons) of GABAergic in spinal associated with gabaergic
1) Confidence 0.07 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20332333 Disease Relevance 0.20 Pain Relevance 0.20
Activation of GABAergic neurons following tooth pulp stimulation.
Gene_expression (neurons) of GABAergic in GABAergic neurons associated with nociceptor and gabaergic
2) Confidence 0.07 Published 2010 Journal J. Dent. Res. Section Title Doc Link 20332333 Disease Relevance 0.28 Pain Relevance 0.41
We found that differences in oscillation frequency between mouse strains may be explained by differences in GABAergic synapse properties and GABAA-receptor subunit expression.


Gene_expression (expression) of GABAergic in synapse associated with gabaergic and sprains and strains
3) Confidence 0.05 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.42 Pain Relevance 0.21
To test whether differences in GABAA-receptor subunit expression in hippocampus of NOD and Balbc mice was reflected in altered kinetics of single GABAergic synapses, we recorded miniature IPSCs (mIPSCs) from CA3 pyramidal neurons while preventing action potential firing by blocking sodium channels with TTX.
Gene_expression (synapses) of GABAergic in pyramidal neurons associated with action potential, pyramidal cell, gabaergic, sodium channel and hippocampus
4) Confidence 0.05 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.07 Pain Relevance 0.55
In the present study, we found that uIPSCs exhibit PPD, which is in agreement with our previous work using field stimulation [22] and suggest the possible high release probabilities of GABAergic synapses in the ACC.
Gene_expression (synapses) of GABAergic in synapses associated with depression, gabaergic, interneuron and anterior cingulate cortex
5) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2770551 Disease Relevance 0.43 Pain Relevance 0.71
However, the failure rate is higher in glutamatergic transmission than in GABAergic transmission.
Gene_expression (transmission) of GABAergic associated with gabaergic
6) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2770551 Disease Relevance 0 Pain Relevance 0.82
Thus, faster GABAergic synapses may give rise to faster recurrent feedback loops between pyramidal cells and interneurons.
Gene_expression (synapses) of GABAergic in synapses associated with pyramidal cell and gabaergic
7) Confidence 0.05 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.13 Pain Relevance 0.41
4, Figure 6A), suggesting that GABAergic synapses in NOD mice may have a different molecular composition or stoichiometry of subunits.
Gene_expression (synapses) of GABAergic in synapses associated with gabaergic
8) Confidence 0.05 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0 Pain Relevance 0.49
Using immunoprecipitation, immunohistochemistry and qPCR methods, we validate the microarray data, including altered GABAergic receptor expression in mice lacking the ?
Gene_expression (expression) of GABAergic receptor associated with gabaergic
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0.28 Pain Relevance 0.19
9 subunit (and therefore silencing of the nAChR) suggests a relationship between the nicotinic and GABAergic systems at the level of gene expression, but a causal link has yet to be demonstrated.
Gene_expression (expression) of GABAergic associated with gabaergic
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0.08 Pain Relevance 0.18
Thus, our data identify the involvement of the AC7 signaling pathway in both ethanol and CRF sensitivity of GABAergic synapses in CeA.


Gene_expression (synapses) of GABAergic in synapses associated with gabaergic and amygdala
11) Confidence 0.04 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.13 Pain Relevance 0.35
Previously we found that ethanol dose-dependently increased GABAergic transmission in CeA slices by increasing presynaptic vesicular GABA release (Roberto et al., 2003).
Gene_expression (transmission) of GABAergic associated with gaba, gabaergic and amygdala
12) Confidence 0.04 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.54
Although our observations in the present study are consistent with our previous data [26], it remains to be determined how deletion of COX-2, but not of COX-1, alters the expression of GABAergic system related genes.


Gene_expression (expression) of GABAergic associated with gabaergic
13) Confidence 0.04 Published 2007 Journal Genome Biol Section Body Doc Link PMC1839133 Disease Relevance 0.20 Pain Relevance 0.33
The migratory neuroblast and GABAergic phenotype of periglomerular cells was reflected in the expression of Dcx [14] (immature neurons) and Gad1 [15] (GAD67 protein in GABAergic interneurons), respectively.
Gene_expression (expression) of GABAergic in interneurons associated with gabaergic
14) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2063466 Disease Relevance 0 Pain Relevance 0.10
In the presence of selected growth factors, tNSCs differentiated into astroglia, oligodendroglia, and neurons expressing markers for cholinergic, GABAergic, and glutamatergic cells.
Gene_expression (expressing) of GABAergic in oligodendroglia associated with gabaergic
15) Confidence 0.04 Published 2006 Journal Stem Cells Section Abstract Doc Link 16373695 Disease Relevance 0.18 Pain Relevance 0.40
To test this idea, we studied the effect of GRP on GABAergic transmission.
Gene_expression (transmission) of GABAergic associated with gabaergic
16) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945970 Disease Relevance 0 Pain Relevance 0.55
Here we show that a generic serotype 2/9 AAV-GFP virus efficiently transfected neurons in the neocortex and drove green fluorescent protein (GFP) expression in both glutamatergic pyramidal neurons and GABAergic interneurons by a strong and ubiquitous CMV promoter, PCMV (Fig. 1a, and data not shown).
Gene_expression (interneurons) of GABAergic in pyramidal neurons associated with gabaergic, pyramidal cell and cytomegalovirus infection
17) Confidence 0.04 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289876 Disease Relevance 0.23 Pain Relevance 0.13
In the present study, we used male HET mice with diminished AC7 activity (Hines et al., 2006) to investigate a role of AC in ethanol- and CRF1-dependent effects on GABAergic transmission in the CeA.
Gene_expression (transmission) of GABAergic associated with gabaergic and amygdala
18) Confidence 0.04 Published 2011 Journal Frontiers in Neuroscience Section Body Doc Link PMC3024005 Disease Relevance 0.27 Pain Relevance 0.71
Therefore, using an in vitro electrophysiological approach in brain slices, here we have investigated a possible role of the AC7 signaling pathway in ethanol and CRF effects on CeA GABAergic synapses of genetically modified mice with diminished brain Adcy7 activity (HET) compared to their littermate male wild-type (WT) mice.
Gene_expression (effects) of GABAergic in synapses associated with gabaergic and amygdala
19) Confidence 0.04 Published 2011 Journal Frontiers in Neuroscience Section Abstract Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.53
Type 7 Adenylyl Cyclase is Involved in the Ethanol and CRF Sensitivity of GABAergic Synapses in Mouse Central Amygdala

The GABAergic system in the central amygdala (CeA) plays a major role in ethanol dependence and in the anxiogenic response to ethanol withdrawal.

Gene_expression (system) of GABAergic in amygdala associated with addiction, gabaergic, withdrawal and amygdala
20) Confidence 0.04 Published 2011 Journal Frontiers in Neuroscience Section Title Doc Link PMC3024005 Disease Relevance 0 Pain Relevance 0.58

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