INT60415

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Context Info
Confidence 0.27
First Reported 1993
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 5.81
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NPEPPS) peptidase activity (NPEPPS) nucleus (NPEPPS)
cytoplasm (NPEPPS)
Anatomy Link Frequency
cartilage 2
articular cartilage 2
synovial fluid 1
chondrocytes 1
lung 1
NPEPPS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 86 100.00 Very High Very High Very High
metalloproteinase 79 100.00 Very High Very High Very High
endometriosis 12 98.88 Very High Very High Very High
aspirin 9 98.32 Very High Very High Very High
cINOD 7 97.72 Very High Very High Very High
Pain 31 87.84 High High
Osteoarthritis 17 78.52 Quite High
Enkephalin 4 75.00 Quite High
Arthritis 39 73.36 Quite High
cva 1 72.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 91 100.00 Very High Very High Very High
Stroke 6 100.00 Very High Very High Very High
Adenocarcinoma 9 99.22 Very High Very High Very High
Arthropathy 7 99.16 Very High Very High Very High
Endometriosis 14 98.88 Very High Very High Very High
Cancer 13 96.52 Very High Very High Very High
Pain 16 87.84 High High
Osteoarthritis 18 86.00 High High
Toxicity 32 85.92 High High
Injury 132 83.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The order of the K(cat)/K(m) values of AAP-S at the optimal pH was Arg->Arg-Arg->Met->Leu->Lys->Phe->Lys-Ala->Tyr->Ala-MCAs.
Regulation (values) of AAP-S
1) Confidence 0.27 Published 2000 Journal Forensic Sci. Int. Section Abstract Doc Link 10978616 Disease Relevance 0 Pain Relevance 0.06
This suggested that once matrix metalloproteinase activity is altered it can remain so with the continued use of the nanocrystalline silver dressing (Kirshner 2002).
Regulation (altered) of metalloproteinase associated with metalloproteinase
2) Confidence 0.13 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676636 Disease Relevance 0.70 Pain Relevance 0.10
In this study, its effect in vivo on the biochemical composition, metabolic activities, and metalloproteinase activities of normal canine articular cartilage was analyzed.
Regulation (effect) of metalloproteinase in articular cartilage associated with metalloproteinase
3) Confidence 0.07 Published 1993 Journal J. Orthop. Res. Section Abstract Doc Link 8483029 Disease Relevance 0.20 Pain Relevance 0.21
The order for k(cat)/Km values of AAP-S at the optimal pH (pH 7.5) was Lys->Met->Arg->Ala->Leu->Phe->Tyr->Lys-Ala-MCAs.
Regulation (values) of AAP-S
4) Confidence 0.05 Published 1998 Journal Biol. Chem. Section Abstract Doc Link 9687021 Disease Relevance 0 Pain Relevance 0.13
In vivo effects of naproxen on composition, proteoglycan metabolism, and matrix metalloproteinase activities in canine articular cartilage.
Regulation (effects) of metalloproteinase in articular cartilage associated with metalloproteinase
5) Confidence 0.05 Published 1993 Journal J. Orthop. Res. Section Title Doc Link 8483029 Disease Relevance 0.19 Pain Relevance 0.31
Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment?
Regulation (role) of Metalloproteinase associated with inflammation, stroke and metalloproteinase
6) Confidence 0.04 Published 2010 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 20955435 Disease Relevance 0.99 Pain Relevance 0.52
It indicates that lung adenocarcinoma G1 should be considered as a possible target for metalloproteinase inhibitory therapy.
Spec (possible) Regulation (target) of metalloproteinase in lung associated with adenocarcinoma and metalloproteinase
7) Confidence 0.03 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.71 Pain Relevance 0.24
Analysis of the cartilage for matrix metalloproteinase activities showed reduced activity of neutral matrix metalloproteinase by 80%, of collagenase by 40%, and of gelatinase by 87%, with no change in activity of acid metalloproteinase or of tissue inhibitor for metalloproteinase.
Neg (no) Regulation (change) of metalloproteinase in cartilage associated with metalloproteinase
8) Confidence 0.03 Published 1993 Journal J. Orthop. Res. Section Abstract Doc Link 8483029 Disease Relevance 0.13 Pain Relevance 0.33
The effect of hyaluronan on induced metalloproteinase activity was mediated partially by CD44, the principal cell surface receptor for hyaluronan.
Regulation (effect) of metalloproteinase associated with metalloproteinase
9) Confidence 0.02 Published 2007 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 18090474 Disease Relevance 0.29 Pain Relevance 0.42
Human cartilage explants, obtained from surgical specimens, were used to assess chondroproteciton with activity related to direct inhibitory effects on human matrix metalloproteinase (MMP, gelatinolytic) activity using synovial fluid and chondrocytes activated with IL-1?
Regulation (effects) of metalloproteinase in chondrocytes associated with metalloproteinase
10) Confidence 0.01 Published 2007 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1971260 Disease Relevance 0.31 Pain Relevance 0.13
In addition, the mechanical environment acting on tenocytes cultured in a three-dimensional matrix has been shown to regulate some metalloproteinase activities (Lavagnino and Arnoczky, 2005).
Regulation (regulate) of metalloproteinase associated with metalloproteinase
11) Confidence 0.01 Published 2008 Journal Matrix Biol Section Body Doc Link PMC2443387 Disease Relevance 0.13 Pain Relevance 0.26
on TIMP are also ambiguous [153], because the regulation of matrix metalloproteinase and TIMP may depend on different tissue domains (superficial versus deep cartilage layers) and may also vary for intracellular and extracellular digestion of collagen [146,152].
Regulation (regulation) of metalloproteinase in cartilage associated with metalloproteinase
12) Confidence 0.00 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.61 Pain Relevance 0.31
Human cartilage explants, obtained from surgical specimens, were used to assess chondroproteciton with activity related to direct inhibitory effects on human matrix metalloproteinase (MMP, gelatinolytic) activity using synovial fluid and chondrocytes activated with IL-1?
Regulation (effects) of metalloproteinase in synovial fluid associated with metalloproteinase
13) Confidence 0.00 Published 2007 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1971260 Disease Relevance 0.31 Pain Relevance 0.13
New pharmaceutical agents affecting inflammation, angiogenesis, and matrix metalloproteinase activity may prevent or inhibit the development of endometriosis.
Regulation (affecting) of metalloproteinase associated with endometriosis, inflammation and metalloproteinase
14) Confidence 0.00 Published 2005 Journal Obstet Gynecol Surv Section Abstract Doc Link 16359564 Disease Relevance 1.25 Pain Relevance 0.64

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