INT6042

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Context Info
Confidence 0.48
First Reported 1982
Last Reported 2010
Negated 6
Speculated 16
Reported most in Abstract
Documents 248
Total Number 264
Disease Relevance 31.77
Pain Relevance 154.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
brain 29
striatum 4
nucleus 3
spinal 3
respiratory 3
Oprm1 (Rattus norvegicus)
Oprm1 - A118G (2) Oprm1 - D114N (1)
Pain Link Frequency Relevance Heat
Morphine 513 100.00 Very High Very High Very High
opioid receptor 480 100.00 Very High Very High Very High
Opioid 360 100.00 Very High Very High Very High
mu opioid receptor 304 100.00 Very High Very High Very High
Pain 225 100.00 Very High Very High Very High
agonist 192 100.00 Very High Very High Very High
Enkephalin 185 100.00 Very High Very High Very High
narcan 120 100.00 Very High Very High Very High
addiction 86 100.00 Very High Very High Very High
alcohol 41 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 300 100.00 Very High Very High Very High
Drug Dependence 33 100.00 Very High Very High Very High
Diabetes Mellitus 10 99.84 Very High Very High Very High
Obesity 16 99.78 Very High Very High Very High
Newborn Drug Withdrawal Syndrome 1 99.78 Very High Very High Very High
Opiate Addiction 14 99.76 Very High Very High Very High
Nociception 28 99.62 Very High Very High Very High
Hypoxia 20 99.60 Very High Very High Very High
Volume Depletion And Dehydration 5 99.56 Very High Very High Very High
Respiratory Tract Infection 10 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic treatment with naltrexone appears to produce a region-specific downregulation of MOR-1 mRNA levels, which may be secondary to the naltrexone-induced increase in mu receptor binding.
mu receptor Binding (binding) of
1) Confidence 0.48 Published 1995 Journal Brain Res. Bull. Section Abstract Doc Link 7583338 Disease Relevance 0.06 Pain Relevance 0.68
The purpose of our investigation was to characterize the relationships between the pharmacodynamics of synthetic opioids in vivo and the interaction at the mu-opioid receptor.
mu-opioid receptor Binding (interaction) of associated with opioid receptor and opioid
2) Confidence 0.48 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9495871 Disease Relevance 0 Pain Relevance 0.36
The interaction at the mu-opioid receptor was determined in vitro on basis of the displacement of [3H]-naloxone binding in washed rat brain membranes.
mu-opioid receptor Binding (interaction) of in brain associated with narcan and opioid receptor
3) Confidence 0.48 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9495871 Disease Relevance 0 Pain Relevance 0.52
Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor.
mu-opioid receptor Binding (interaction) of associated with rapifen, opioid receptor and opioid
4) Confidence 0.48 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9495871 Disease Relevance 0 Pain Relevance 0.61
We determined responses to noxious thermal stimuli, before and after morphine, and mu-opioid receptor binding in brain regions involved in nociception in maternally separated (MS), neonatally handled (H) and nonhandled (NH) female rats.
mu-opioid receptor Binding (binding) of in brain associated with nociception, opioid receptor and morphine
5) Confidence 0.48 Published 2007 Journal J Pain Section Abstract Doc Link 17686657 Disease Relevance 0.17 Pain Relevance 0.32
In conclusion, MS and H treatments led to antipodal differences in pain sensitivity in female rats and differential mu-opioid receptor binding in the medial preoptic nucleus.
mu-opioid receptor Binding (binding) of in medial preoptic nucleus associated with pain and opioid receptor
6) Confidence 0.48 Published 2007 Journal J Pain Section Abstract Doc Link 17686657 Disease Relevance 0.32 Pain Relevance 1.10
Rats were killed during diestrous and mu-opioid receptor binding was determined in discrete brain regions, using [(3)H]DAMGO autoradiography.
mu-opioid receptor Binding (binding) of in brain associated with opioid receptor
7) Confidence 0.48 Published 2007 Journal J Pain Section Abstract Doc Link 17686657 Disease Relevance 0.22 Pain Relevance 0.55
Competition binding assays showed that compounds 10a-h bound to the mu opioid receptor with high affinity (0.2-0.6 nM).
mu opioid receptor Binding (bound) of associated with mu opioid receptor
8) Confidence 0.48 Published 2004 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15498674 Disease Relevance 0 Pain Relevance 0.35
In CP-55,940 exposed rats, mu opioid receptor binding was significantly raised in the lateral thalamus and periaqueductal gray (PAG), with an increase in DAMGO-stimulated [35S]GTPgammaS binding in the nucleus accumbens.
mu opioid receptor Binding (binding) of in thalamus associated with nucleus accumbens, mu opioid receptor, urological neuroanatomy, thalamus and central grey
9) Confidence 0.48 Published 2005 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 16079992 Disease Relevance 0.19 Pain Relevance 1.45
These results suggest that normethadone-like compounds may interact with the P subsite of the mu-opioid receptor and that the P subsite has a well-defined cavity shape of stringent dimensions.
mu-opioid receptor Binding (interact) of in cavity associated with opioid receptor
10) Confidence 0.48 Published 1995 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 7602488 Disease Relevance 0 Pain Relevance 0.10
Thus, blockade by opiates of effects of naltrexone appears to be due to a competitive interaction at the mu opioid receptor; clonidine has a different mechanism of action.
mu opioid receptor Binding (interaction) of associated with mu opioid receptor, opiate and clonidine
11) Confidence 0.48 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 4039002 Disease Relevance 0.38 Pain Relevance 1.45
One antibody recognized a specific site for MOR1, and the other bound to a common site for MOR1 and MOR1B.
MOR1 Binding (recognized) of
12) Confidence 0.48 Published 1996 Journal J. Comp. Neurol. Section Abstract Doc Link 8698899 Disease Relevance 0.09 Pain Relevance 0.63
When stably expressed in HEK 293 cells, both splice variants bind the mu receptor agonist [D-Ala2,N-Me-Phe4,-Gly-ol5]enkephalin (DAMGO) with similar affinity and exhibit functional coupling to adenylyl cyclase with similar efficiency.
mu receptor Binding (bind) of associated with agonist and enkephalin
13) Confidence 0.48 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9593704 Disease Relevance 0 Pain Relevance 0.34
mu-Opioid receptor mRNA expression in the rat CNS: comparison to mu-receptor binding.
mu-receptor Binding (binding) of associated with enkephalin and opioid receptor
14) Confidence 0.48 Published 1994 Journal Brain Res. Section Title Doc Link 8032920 Disease Relevance 0 Pain Relevance 0.38
The fentanyl opiate analogues are an important group of analgesics that interact with the mu opioid receptor.
mu opioid receptor Binding (interact) of associated with analgesic, mu opioid receptor and opiate
15) Confidence 0.48 Published 2003 Journal Teratog., Carcinog. Mutagen. Section Abstract Doc Link 12616604 Disease Relevance 0.14 Pain Relevance 1.22
In vitro, thienorphine was more potent than buprenorphine in inhibiting [3H]diprenorphine and stimulating guanosine 5'-O-(3-[35S]thio)triphosphate binding to rat mu-opioid receptor stably expressed in CHO cells.
mu-opioid receptor Binding (binding) of associated with opioid receptor and buprenorphine
16) Confidence 0.48 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16569757 Disease Relevance 0.07 Pain Relevance 1.29
In conclusion, all these data overall suggest that structural maneuvering in the Pro(6)-residue of the DM molecule changes its affinity for mu-opioid receptor subtypes and confirms the usefulness of experimental studies involving structural modifications in obtaining new therapeutic agents.
mu-opioid receptor Binding (affinity) of associated with opioid receptor
17) Confidence 0.48 Published 2003 Journal Peptides Section Abstract Doc Link 12732340 Disease Relevance 0.07 Pain Relevance 0.18
At the central mu receptor, nalmefene bound with an IC50 of 1.0 nM, equal to that of naltrexone and approximately four times lower than that of naloxone.
mu receptor Binding (bound) of associated with narcan
18) Confidence 0.48 Published 1985 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 2991678 Disease Relevance 0 Pain Relevance 0.74
In group-housed rats, mu receptor binding was unchanged in the frontal cortex, whereas Ket-injected animals had decreased levels in the hippocampus.
mu receptor Binding (binding) of in hippocampus
19) Confidence 0.48 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 17016710 Disease Relevance 0.11 Pain Relevance 0
Moreover, the data suggest that modifications in mu opioid receptor binding contribute to this phenomenon.


mu opioid receptor Binding (binding) of
20) Confidence 0.48 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 17016710 Disease Relevance 0 Pain Relevance 0

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