INT60422

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.16
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Mln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 100.00 Very High Very High Very High
opiate 1 100.00 Very High Very High Very High
Morphine 5 99.88 Very High Very High Very High
tetrodotoxin 3 95.84 Very High Very High Very High
Serotonin 4 94.80 High High
antagonist 1 90.28 High High
Somatostatin 3 78.08 Quite High
abdominal pain 2 56.56 Quite High
spastic colon 1 50.88 Quite High
Disease Link Frequency Relevance Heat
Abdominal Pain 2 56.56 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 54.00 Quite High
Functional Bowel Disorder 1 50.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Carbachol dose-dependently stimulated the release of motilin from its producing cell.
Positive_regulation (stimulated) of Localization (release) of motilin
1) Confidence 0.58 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.21
Bombesin, morphine, and erythromycin, recognized stimulants for motilin release in vivo, failed to influence the secretion of motilin in vitro.
Positive_regulation (stimulants) of Localization (release) of motilin associated with morphine
2) Confidence 0.42 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.22
Bombesin and morphine also increased the release of motilin.
Positive_regulation (increased) of Localization (release) of motilin associated with morphine
3) Confidence 0.40 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.58
The actions of trimebutine [3,4,5-trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutylester] on the gastrointestinal tract are mediated via (i) an agonist effect on peripheral mu, kappa and delta opiate receptors and (ii) release of gastrointestinal peptides such as motilin and modulation of the release of other peptides, including vasoactive intestinal peptide, gastrin and glucagon.
Positive_regulation (mediated) of Localization (release) of motilin associated with agonist and opiate
4) Confidence 0.38 Published 1997 Journal J. Int. Med. Res. Section Abstract Doc Link 9364286 Disease Relevance 0.11 Pain Relevance 0.26

General Comments

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