INT60423

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 11.02
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSG1)
Anatomy Link Frequency
skin 3
mast cell 3
plasma 1
TPSG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 9 99.84 Very High Very High Very High
cva 8 98.90 Very High Very High Very High
fibrosis 1 98.72 Very High Very High Very High
Pain 3 97.98 Very High Very High Very High
abdominal pain 1 97.26 Very High Very High Very High
ischemia 1 97.00 Very High Very High Very High
pruritus 1 96.58 Very High Very High Very High
headache 2 95.92 Very High Very High Very High
Neuropeptide 1 94.92 High High
Neurotransmitter 1 94.24 High High
Disease Link Frequency Relevance Heat
Eosinophilia 1 99.96 Very High Very High Very High
Interstitial Cystitis 9 99.84 Very High Very High Very High
Erythema 2 99.84 Very High Very High Very High
Anaphylaxis 22 99.48 Very High Very High Very High
Pressure Volume 2 Under Development 2 99.24 Very High Very High Very High
Myelofibrosis 1 99.20 Very High Very High Very High
Amniotic Fluid Embolism 7 98.90 Very High Very High Very High
Bronchospasm 2 98.80 Very High Very High Very High
Myocardial Infarction 3 98.72 Very High Very High Very High
Osteoporosis 1 98.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mast cell participation in the pathogenesis of this syndrome has been proved by the finding of an elevated serum histamine level during experimentally-induced attacks and by cutaneous degranulation of mast cells with elevated serum tryptase after attacks.
Positive_regulation (elevated) of serum tryptase in mast cells associated with syndrome
1) Confidence 0.57 Published 2008 Journal Recenti Prog Med Section Abstract Doc Link 18751620 Disease Relevance 1.25 Pain Relevance 0.10
Diamorphine was subject to degradation over the course of the in vitro experiments to produce significant amounts of 6-monoacetylmorphine and evidence is presented to suggest that this was due to residual skin esterase activity.
Positive_regulation (due) of skin esterase in skin
2) Confidence 0.46 Published 1993 Journal Pharm. Res. Section Abstract Doc Link 8483842 Disease Relevance 0.07 Pain Relevance 0.16
An elevated serum tryptase concentration was observed, and subsequent skin testing revealed negative reactions to some drugs administered in this case.
Positive_regulation (elevated) of serum tryptase in skin
3) Confidence 0.43 Published 2010 Journal J Anesth Section Abstract Doc Link 20052499 Disease Relevance 0.64 Pain Relevance 0.22
A serum tryptase concentration was markedly elevated 2 hours after the anaphylactic episode.
Positive_regulation (elevated) of serum tryptase associated with anaphylaxis
4) Confidence 0.33 Published 2007 Journal Allergy Asthma Proc Section Abstract Doc Link 18034982 Disease Relevance 0.94 Pain Relevance 0.28
Cardiac enzymes and troponin, serum tryptase, and histamine were elevated.
Positive_regulation (elevated) of serum tryptase
5) Confidence 0.05 Published 2006 Journal Eur. J. Intern. Med. Section Abstract Doc Link 16618460 Disease Relevance 1.20 Pain Relevance 0.21
Mast cell-derived proteases can directly cause tissue damage, and it is noteworthy that urine tryptase is elevated in IC.
Positive_regulation (elevated) of urine tryptase in Mast cell associated with interstitial cystitis
6) Confidence 0.04 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9629289 Disease Relevance 1.05 Pain Relevance 0.89
Elevated plasma tryptase levels were evident in the three adult males; two of the three victims displayed elevated IgE levels.
Positive_regulation (Elevated) of plasma tryptase in plasma
7) Confidence 0.02 Published 2008 Journal Leg Med (Tokyo) Section Abstract Doc Link 18035583 Disease Relevance 0.33 Pain Relevance 0
Typical clinical and laboratory features of SM include urticaria pigmentosa, mast cell mediator symptoms (eg, headache, flushing, lightheadedness, urticaria and pruritus, nausea, diarrhea, abdominal pain, and vasodilatory shock), bone pain (eg, osteoporosis, lytic bone lesions, and fractures), hepatosplenomegaly, cytopenia, eosinophilia, elevated serum tryptase and histamine, and bone marrow fibrosis and angiogenesis.
Positive_regulation (elevated) of serum tryptase in mast cell associated with urticaria, pain, abdominal pain, diarrhoea, shock, myelofibrosis, eosinophilia, fibrosis, vomiting, osteoporosis, increased venous pressure under development, systemic mastocytosis, pruritus, dizziness, headache and urticaria pigmentosa
8) Confidence 0.01 Published 2004 Journal Curr. Hematol. Rep. Section Abstract Doc Link 15087068 Disease Relevance 2.67 Pain Relevance 0.43
An important diagnostic clue in such cases is an increased serum tryptase level.
Positive_regulation (increased) of serum tryptase
9) Confidence 0.01 Published 2004 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 15241337 Disease Relevance 1.75 Pain Relevance 0.10
Baseline tryptase was higher in skin test-positive patients (median, 11.5 vs 3.7 microg/L), and 6 of 7 patients had elevated IgE to chlorhexidine in serum at the time of reaction.
Positive_regulation (higher) of Baseline tryptase in skin
10) Confidence 0.00 Published 2007 Journal J. Allergy Clin. Immunol. Section Body Doc Link 17559915 Disease Relevance 0.06 Pain Relevance 0
In recent years it has been suggested that AFE is an anaphylactoid reaction to fetal antigens and an elevated serum tryptase level is increasingly being used to support the diagnosis.
Positive_regulation (elevated) of serum tryptase associated with anaphylaxis and cva
11) Confidence 0.00 Published 2009 Journal Middle East J Anesthesiol Section Abstract Doc Link 19583089 Disease Relevance 1.06 Pain Relevance 0.17

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