INT6043

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1982
Last Reported 2006
Negated 2
Speculated 1
Reported most in Abstract
Documents 24
Total Number 25
Disease Relevance 2.67
Pain Relevance 16.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
brain 10
striatum 7
spinal 2
globus pallidus 2
amygdala 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 54 100.00 Very High Very High Very High
Opioid 42 100.00 Very High Very High Very High
mu opioid receptor 21 100.00 Very High Very High Very High
Enkephalin 40 99.92 Very High Very High Very High
intrathecal 2 99.64 Very High Very High Very High
Immobilon 21 99.52 Very High Very High Very High
antidepressant 4 99.40 Very High Very High Very High
Locus ceruleus 1 99.40 Very High Very High Very High
Potency 6 99.32 Very High Very High Very High
narcan 17 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 2 97.80 Very High Very High Very High
Movement Disorders 1 95.72 Very High Very High Very High
Bordatella Infection 8 94.84 High High
Alcohol Addiction 1 94.32 High High
Catatonia 1 94.24 High High
Parkinson's Disease 12 93.36 High High
Urological Neuroanatomy 3 92.64 High High
Convulsion 1 90.28 High High
Epilepsy 1 88.00 High High
Syndrome 1 87.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreased mu-opioid receptor binding in the globus pallidus of rats treated with chronic haloperidol.
Negative_regulation (Decreased) of mu-opioid receptor Binding (binding) of in globus pallidus associated with opioid receptor
1) Confidence 0.57 Published 2000 Journal Psychopharmacology (Berl.) Section Title Doc Link 10923753 Disease Relevance 0.18 Pain Relevance 0.31
In Tris buffer morphiceptin potently inhibited the binding of the mu receptor marker [125I]FK 33,824 but displayed the expected shallow displacement isotherm against binding of the delta receptor marker [125I][D-Ala2, D-Leu5]enkephalin.
Negative_regulation (inhibited) of mu receptor Binding (binding) of associated with enkephalin
2) Confidence 0.53 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6094789 Disease Relevance 0 Pain Relevance 0.81
Stimulation of the mossy fibers (containing both dynorphins and enkephalins) also significantly reduced mu receptor binding, but to a lesser extent.
Negative_regulation (reduced) of mu receptor Binding (binding) of in mossy fibers associated with enkephalin
3) Confidence 0.52 Published 1990 Journal Neuroscience Section Abstract Doc Link 1978741 Disease Relevance 0 Pain Relevance 0.92
Mu-opioid receptor binding in the GP was significantly decreased in symptomatic cats and remained significantly decreased in recovered cats.
Negative_regulation (decreased) of Mu-opioid receptor Binding (binding) of associated with opioid receptor
4) Confidence 0.51 Published 2002 Journal Brain Res. Section Abstract Doc Link 12176171 Disease Relevance 0.51 Pain Relevance 0.61
In contrast, mu-opioid receptor binding decreased in these brain regions in naloxone-precipitated withdrawal from morphine, but not butorphanol, while binding for delta-opioid receptors was altered in both withdrawal groups.
Neg (not) Negative_regulation (decreased) of mu-opioid receptor Binding (binding) of in brain associated with butorphanol, narcan, delta opioid receptors, opioid receptor, withdrawal and morphine
5) Confidence 0.49 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 12127012 Disease Relevance 0.17 Pain Relevance 2.35
When mu- and delta-binding was determined using [3H]diprenorphine in the presence of morphiceptin or DPDPE respectively, a significant decrease (20-30%) in the mu-opioid receptor binding but not in delta-opioid receptor binding was observed in all the brain areas tested after 5 days of PL017 treatment.
Negative_regulation (decrease) of mu-opioid receptor Neg (not) Binding (binding) of in brain associated with opioid receptor
6) Confidence 0.48 Published 1990 Journal Brain Res. Section Abstract Doc Link 2175241 Disease Relevance 0.09 Pain Relevance 0.58
Thus, analogous to previous observations in which chronic etorphine treatment preferentially reduced mu-opioid receptor binding, chronic DADLE treatment preferentially reduced delta-opioid receptor binding activity.
Negative_regulation (reduced) of mu-opioid receptor Binding (binding) of associated with opioid receptor and immobilon
7) Confidence 0.44 Published 1988 Journal Brain Res. Section Abstract Doc Link 2847851 Disease Relevance 0 Pain Relevance 0.74
High affinity binding of ligands to the mu opioid receptor was reduced by the addition of sodium and guanosine diphosphate at concentrations used in the [35S]GTP gamma S binding assay.
Negative_regulation (reduced) of mu opioid receptor Binding (binding) of associated with mu opioid receptor
8) Confidence 0.43 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8819494 Disease Relevance 0.21 Pain Relevance 1.25
In singly housed animals, mu receptor binding in Ket-injected rats increased in the frontal cortex and decreased in the hippocampus. (35)S-GTPgamma-S binding increased in the frontal cortex in both singly housed groups, but remained unchanged in the hippocampus.
Negative_regulation (decreased) of mu receptor Binding (binding) of in frontal cortex
9) Confidence 0.42 Published 2006 Journal Psychopharmacology (Berl.) Section Body Doc Link 17016710 Disease Relevance 0.05 Pain Relevance 0
When the relative decrease in mu and delta opioid receptor binding was determined by carrying out [3H]-D-Ala2, DLeu5-enkephalin binding in the presence of 1 microM morphiceptin, it was observed that, 3 days after etorphine treatment, there was a decrease in mu opioid receptor binding, with minimal change in delta opioid receptor binding in both brain regions of striatum and midbrain.
Negative_regulation (decrease) of mu opioid receptor Binding (binding) of in striatum associated with mu opioid receptor, midbrain, enkephalin, opioid receptor and immobilon
10) Confidence 0.42 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3031275 Disease Relevance 0 Pain Relevance 0.91
A number of C-terminal modifications decreased the binding affinity to the mu-opioid receptor and the intrinsic activity in rat brain membranes.
Negative_regulation (decreased) of mu-opioid receptor Binding (affinity) of in brain associated with opioid receptor
11) Confidence 0.40 Published 2002 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11779147 Disease Relevance 0 Pain Relevance 0.19
Mu-opioid receptor binding in the GP was significantly decreased in symptomatic cats and remained significantly decreased in recovered cats.
Negative_regulation (decreased) of Mu-opioid receptor Binding (binding) of associated with opioid receptor
12) Confidence 0.37 Published 2002 Journal Brain Res. Section Abstract Doc Link 12176171 Disease Relevance 0.51 Pain Relevance 0.63
Chronic antidepressant treatment causes a selective reduction of mu-opioid receptor binding and functional coupling to G Proteins in the amygdala of fawn-hooded rats.
Negative_regulation (reduction) of mu-opioid receptor Binding (binding) of in amygdala associated with antidepressant, opioid receptor and amygdala
13) Confidence 0.37 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 15121763 Disease Relevance 0.18 Pain Relevance 0.73
One day later, mu-opioid receptor binding, as assessed by receptor autoradiography, was abolished in the injected striatum, while [3H]spiperone binding remained largely unaffected.
Negative_regulation (abolished) of mu-opioid receptor Binding (binding) of in striatum associated with opioid receptor
14) Confidence 0.36 Published 1988 Journal Neurosci. Lett. Section Abstract Doc Link 2840610 Disease Relevance 0 Pain Relevance 0.39
Tolerance to the antinociceptive effect of [D-Ala2,D-Leu5]enkephalin (DADLE) developed in Sprague-Dawley rats given the peptide chronically. delta-Opioid receptor binding is significantly reduced in P2 membranes from various brain areas after 1-3 days' treatment. mu-Opioid receptor binding, however, is reduced only in striatum, and only after 5 days.
Negative_regulation (reduced) of mu-Opioid receptor Binding (binding) of in striatum associated with tolerance, opioid receptor, enkephalin and antinociceptive
15) Confidence 0.33 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8384111 Disease Relevance 0 Pain Relevance 0.64
Continuous intrathecal opioid treatment abolishes the regulatory effects of magnesium and guanine nucleotides on mu opioid receptor binding in rat spinal membranes.
Negative_regulation (abolishes) of mu opioid receptor Binding (binding) of in spinal associated with narcan, mu opioid receptor, opioid and intrathecal
16) Confidence 0.31 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1320689 Disease Relevance 0.31 Pain Relevance 0.82
A significant reduction in delta- but not mu-receptor binding was detected in slices treated with DADLE.
Negative_regulation (reduction) of mu-receptor Binding (binding) of
17) Confidence 0.23 Published 1983 Journal Life Sci. Section Abstract Doc Link 6319888 Disease Relevance 0 Pain Relevance 0.74
Experiments were carried out to determine opioid peptide release, mu receptor binding and proenkephalin expression in rat brain, as well as nociceptive responses, following the administration of a sub-convulsant dose of pentylenetetrazol (PTZ) (30 mg/kg, i.p.).
Spec (determine) Negative_regulation (determine) of mu receptor Binding (binding) of in brain associated with nociception and opioid
18) Confidence 0.22 Published 1999 Journal Epilepsy Res. Section Abstract Doc Link 10510980 Disease Relevance 0.28 Pain Relevance 0.40
Physiological concentrations of zinc were inhibitory to mu receptor binding, whereas the delta and kappa receptors were relatively insensitive to this inhibition.
Negative_regulation (inhibitory) of mu receptor Binding (binding) of
19) Confidence 0.19 Published 1990 Journal Neuropharmacology Section Abstract Doc Link 2162496 Disease Relevance 0 Pain Relevance 0.57
When the relative decrease in mu and delta opioid receptor binding was determined by carrying out [3H]-D-Ala2, DLeu5-enkephalin binding in the presence of 1 microM morphiceptin, it was observed that, 3 days after etorphine treatment, there was a decrease in mu opioid receptor binding, with minimal change in delta opioid receptor binding in both brain regions of striatum and midbrain.
Negative_regulation (decrease) of mu opioid receptor in midbrain Binding (binding) of in striatum associated with mu opioid receptor, midbrain, enkephalin, opioid receptor and immobilon
20) Confidence 0.14 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3031275 Disease Relevance 0 Pain Relevance 0.91

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox