INT60434

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Context Info
Confidence 0.46
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 10.01
Pain Relevance 10.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
liver 8
keratinocyte 4
macrophage 2
neuron 2
nucleus 2
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 28 100.00 Very High Very High Very High
chemokine 10 100.00 Very High Very High Very High
Neuropathic pain 4 100.00 Very High Very High Very High
fluoxetine 11 99.84 Very High Very High Very High
withdrawal 5 99.80 Very High Very High Very High
Enkephalin 15 99.56 Very High Very High Very High
Inflammation 27 99.52 Very High Very High Very High
Thermal hyperalgesia 5 99.44 Very High Very High Very High
Infliximab 1 99.38 Very High Very High Very High
ketamine 15 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 17 100.00 Very High Very High Very High
Cancer 13 100.00 Very High Very High Very High
Neuropathic Pain 10 100.00 Very High Very High Very High
Multiple Sclerosis 3 99.56 Very High Very High Very High
INFLAMMATION 34 99.52 Very High Very High Very High
Hyperalgesia 5 99.44 Very High Very High Very High
Gliosis 1 99.00 Very High Very High Very High
Hepatotoxicity 5 97.94 Very High Very High Very High
Cognitive Disorder 1 95.52 Very High Very High Very High
Headache 1 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KA-induced gliosis and proinflammatory marker (COX-2, IL-1beta, and TNF-alpha) inductions were also suppressed by fluoxetine administration.
Negative_regulation (suppressed) of Positive_regulation (inductions) of TNF-alpha associated with gliosis and fluoxetine
1) Confidence 0.46 Published 2009 Journal Brain Res. Section Abstract Doc Link 19427844 Disease Relevance 0.73 Pain Relevance 1.18
In this study, we demonstrated that ST inhibited lipopolysaccaride (LPS)-induced tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 production.
Negative_regulation (inhibited) of Positive_regulation (induced) of tumor necrosis factor associated with necrosis and cancer
2) Confidence 0.42 Published 2008 Journal Am. J. Chin. Med. Section Abstract Doc Link 19051342 Disease Relevance 0.55 Pain Relevance 0.22
As a result, pretreated with ASE prior to the administration of APAP significantly prevented the increases of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum, and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation in liver tissue.
Negative_regulation (prevented) of Positive_regulation (increases) of tumor necrosis factor-alpha in liver associated with necrosis, paracetamol and cancer
3) Confidence 0.41 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801828 Disease Relevance 0.55 Pain Relevance 0.59
The concomitant administration of pentoxifylline (decreasing TNF-alpha secretion) and infliximab (trapping TNF-alpha) likewise attenuated the Jo2-mediated increase in TNF-alpha, the decrease in hepatic glutathione, and the increase in serum ALT activity 5 h after Jo2 administration.
Negative_regulation (attenuated) of Positive_regulation (increase) of TNF-alpha associated with infliximab
4) Confidence 0.40 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18572215 Disease Relevance 0.64 Pain Relevance 0.20
RESULTS: Pretreated with EEP prior to the administration of APAP significantly prevented the increases of AST, ALT, and TNF-alpha levels in sera, and suppressed the GSH depletion, MDA accumulation in liver tissues markedly.
Negative_regulation (prevented) of Positive_regulation (increases) of TNF-alpha in liver
5) Confidence 0.40 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 19833181 Disease Relevance 0.08 Pain Relevance 0
PSL-induced upregulation of tumor necrosis factor-alpha and interleukin-6, which are essential for neuropathic pain, was suppressed by pioglitazone for the first week.
Negative_regulation (suppressed) of Positive_regulation (upregulation) of tumor necrosis factor-alpha associated with necrosis, cancer and neuropathic pain
6) Confidence 0.38 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19008646 Disease Relevance 1.55 Pain Relevance 1.56
Furthermore, Cardiospermum halicacabum L. ethanol extract inhibited the TNF-alpha induced DNA binding activity of NF-kappaB, which was associated with decreased p65 protein level in the nucleus in Jurkat cells.
Negative_regulation (inhibited) of Positive_regulation (induced) of TNF-alpha in nucleus
7) Confidence 0.37 Published 2009 Journal J Ethnopharmacol Section Body Doc Link 19393729 Disease Relevance 0.06 Pain Relevance 0
When murine J774 macrophages were incubated with the sesquiterpene lactone, LPS-induced IL-1beta, tumor necrosis factor-alpha (TNF-alpha) and keratinocyte-derived chemokine (KC) release were concentration-dependently inhibited.
Negative_regulation (inhibited) of Positive_regulation (induced) of TNF-alpha in keratinocyte associated with chemokine, necrosis and cancer
8) Confidence 0.36 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19524419 Disease Relevance 0.66 Pain Relevance 0.40
When murine J774 macrophages were incubated with the sesquiterpene lactone, LPS-induced IL-1beta, tumor necrosis factor-alpha (TNF-alpha) and keratinocyte-derived chemokine (KC) release were concentration-dependently inhibited.
Negative_regulation (inhibited) of Positive_regulation (induced) of tumor necrosis factor-alpha in keratinocyte associated with chemokine, necrosis and cancer
9) Confidence 0.36 Published 2009 Journal Phytomedicine Section Abstract Doc Link 19524419 Disease Relevance 0.66 Pain Relevance 0.40
Meanwhile, cotreatment with ketamine and lipopolysaccharide significantly inhibited lipopolysaccharide-induced TNF-alpha, IL-1beta, and IL-6 mRNA levels.
Negative_regulation (inhibited) of Positive_regulation (lipopolysaccharide-induced) of TNF-alpha associated with ketamine
10) Confidence 0.36 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15781291 Disease Relevance 0.15 Pain Relevance 0.68
Results show that, while the systemic pressure was elevated 2 hr after administration of rMuTNF-alpha, D-xylose absorption was severely depressed.
Negative_regulation (depressed) of Positive_regulation (elevated) of rMuTNF-alpha
11) Confidence 0.36 Published 1993 Journal Circ. Shock Section Abstract Doc Link 8485819 Disease Relevance 0.76 Pain Relevance 0.15
SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-alpha but also APAP-induced GSH depletion and MDA accumulation.
Negative_regulation (blocked) of Positive_regulation (increases) of TNF-alpha associated with paracetamol and hepatotoxicity
12) Confidence 0.32 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.66 Pain Relevance 0.98
Spleen cells from mice undergoing withdrawal also had decreased splenic mRNA and/or protein levels of IL-1beta, IL-1Ra, TNF-alpha, IL-12, and IFN-gamma.
Negative_regulation (decreased) of Positive_regulation (levels) of TNF-alpha in Spleen associated with withdrawal
13) Confidence 0.31 Published 2003 Journal J. Neuroimmunol. Section Abstract Doc Link 14597094 Disease Relevance 0 Pain Relevance 0.49
SA13353 inhibited LPS-induced TNF-alpha and interleukin (IL)-1beta production while augmenting IL-10 production in mice.
Negative_regulation (inhibited) of Positive_regulation (induced) of TNF-alpha
14) Confidence 0.31 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19878665 Disease Relevance 0.27 Pain Relevance 0.51
The increase in TNF-alpha levels preceded the increase in IL-1beta and KC/CXCL1.
Negative_regulation (preceded) of Positive_regulation (increase) of TNF-alpha
15) Confidence 0.30 Published 2008 Journal Eur J Pain Section Abstract Doc Link 18372199 Disease Relevance 0.28 Pain Relevance 0.24
The increase in TNF-alpha, LBP and CD14 mRNA expression in mouse liver after BCG and LPS injection was significantly decreased by paeoniflorin (100 mg/kg) and was changed by paeoniflorin (25, 50 mg/kg) at different time-point.
Negative_regulation (decreased) of Positive_regulation (increase) of TNF-alpha in liver
16) Confidence 0.27 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 16620297 Disease Relevance 0.97 Pain Relevance 0.08
As a result, pretreated with ASE prior to the administration of APAP significantly prevented the increases of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum, and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation in liver tissue.
Negative_regulation (prevented) of Positive_regulation (increases) of TNF-alpha in liver associated with necrosis, paracetamol and cancer
17) Confidence 0.27 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801828 Disease Relevance 0.55 Pain Relevance 0.59
In addition, results show that the inhibition of IFN-gamma synthesis and splenic- and lymph node-lymphocyte proliferation and activation of macrophage TNF-alpha and IL-1beta synthesis occurred only with chronic morphine treatment but not with CORT infusion.
Negative_regulation (inhibition) of Positive_regulation (activation) of TNF-alpha in macrophage associated with morphine
18) Confidence 0.25 Published 2002 Journal J. Leukoc. Biol. Section Abstract Doc Link 11994502 Disease Relevance 0.07 Pain Relevance 0.92
Further, both LE and DTLE (10(-14), 10(-13) M) reduced the LPS-induced tumor necrosis factor-alpha (TNFalpha) mRNA and TNFalpha protein from PHOX+/+ microglia, as determined by quantitative real-time RT-PCR and ELISA analysis in mesencephalic neuron-glia cultures, respectively.
Negative_regulation (reduced) of Positive_regulation (induced) of TNFalpha in neuron associated with necrosis, cancer and enkephalin
19) Confidence 0.19 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16179514 Disease Relevance 0.35 Pain Relevance 1.28
Moreover, co-incubation of LTB4 (but not fMLP, TNF-alpha and MIP-1alpha) with SGE inhibited the ability of LTB4 to induce neutrophil migration in vivo and in vitro.
Negative_regulation (inhibited) of Positive_regulation (co-incubation) of TNF-alpha in neutrophil
20) Confidence 0.14 Published 2005 Journal Eur. J. Immunol. Section Abstract Doc Link 15997469 Disease Relevance 0.46 Pain Relevance 0.17

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