INT6044

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Context Info
Confidence 0.61
First Reported 1986
Last Reported 2010
Negated 5
Speculated 5
Reported most in Abstract
Documents 16
Total Number 20
Disease Relevance 3.01
Pain Relevance 11.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
spinal 4
brain 4
nucleus accumbens 2
cerebral cortex 2
thalamus 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 38 100.00 Very High Very High Very High
Opioid 31 100.00 Very High Very High Very High
Enkephalin 20 100.00 Very High Very High Very High
mu opioid receptor 17 100.00 Very High Very High Very High
Analgesic 7 100.00 Very High Very High Very High
Cholecystokinin 1 100.00 Very High Very High Very High
medulla 2 99.68 Very High Very High Very High
Inflammation 10 99.56 Very High Very High Very High
amygdala 7 99.28 Very High Very High Very High
intrathecal 2 99.14 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 8 100.00 Very High Very High Very High
Volume Depletion And Dehydration 2 99.78 Very High Very High Very High
INFLAMMATION 7 99.56 Very High Very High Very High
Vibrio Infection 5 96.48 Very High Very High Very High
Depression 1 93.48 High High
Lordosis 1 90.96 High High
Hypersensitivity 2 89.44 High High
Nociception 4 87.40 High High
Morphine Dependence 4 86.32 High High
Alcohol Addiction 1 86.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, all these data overall suggest that structural maneuvering in the Pro(6)-residue of the DM molecule changes its affinity for mu-opioid receptor subtypes and confirms the usefulness of experimental studies involving structural modifications in obtaining new therapeutic agents.
Regulation (changes) of mu-opioid receptor Binding (affinity) of associated with opioid receptor
1) Confidence 0.61 Published 2003 Journal Peptides Section Abstract Doc Link 12732340 Disease Relevance 0.07 Pain Relevance 0.21
Alteration of the interaction of mu-opioid receptor and G protein after chronic PL017 treatment in rats.
Regulation (Alteration) of mu-opioid receptor Binding (interaction) of associated with analgesic and opioid receptor
2) Confidence 0.53 Published 1995 Journal Chin J Physiol Section Title Doc Link 8846729 Disease Relevance 0 Pain Relevance 1.07
Quantitative autoradiography showed that chronic dehydration causes no changes in mu receptor binding in the medulla oblongata of Long-Evans rats.
Neg (no) Regulation (changes) of mu receptor Binding (binding) of in medulla oblongata associated with medulla and volume depletion and dehydration
3) Confidence 0.31 Published 1986 Journal Brain Res. Section Abstract Doc Link 3008947 Disease Relevance 0.10 Pain Relevance 0.50
In contrast, no significant changes in mu opioid receptor binding were observed in amygdala or thalamus using [3H]DAMGO autoradiography.
Neg (no) Regulation (changes) of mu opioid receptor Binding (binding) of in thalamus associated with mu opioid receptor, thalamus and amygdala
4) Confidence 0.31 Published 2005 Journal Life Sci. Section Abstract Doc Link 15890372 Disease Relevance 0 Pain Relevance 0.66
Fentanyl at all doses showed no significant effect on the capacity (Bmax) and affinity (Kd) of the mu-opioid receptor binding of DAMGO to whole brain (Bmax 126.2 +/- 3.00 fmol/mg protein, Kd 1.00 +/- 0.04 nM) and spinal cord (Bmax 48.24 +/- 2.71 fmol/mg protein, Kd 1.93 +/- 0.13 nM) membranes gained from the rats after killing them at day 8.
Neg (no) Regulation (effect) of mu-opioid receptor Binding (binding) of in brain associated with opioid receptor and spinal cord
5) Confidence 0.26 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9264090 Disease Relevance 0 Pain Relevance 0.51
Molecular modeling studies were carried out on a set of piperazine and 3,8-diazabicyclo[3.2.1]octane derivatives with the aim to highlight the main factors modulating their affinity for the mu-opioid receptor.
Regulation (modulating) of mu-opioid receptor Binding (affinity) of associated with opioid receptor
6) Confidence 0.24 Published 1993 Journal J. Comput. Aided Mol. Des. Section Abstract Doc Link 8294946 Disease Relevance 0 Pain Relevance 0.14
The basal extracellular levels of the Met-enkephalin-like immunoreactivity in the nucleus accumbens were significantly lower in deprived rats when compared with nondeprived animals, whereas no change in mu-opioid receptor binding occurred.
Neg (no) Regulation (change) of mu-opioid receptor Binding (binding) of in nucleus accumbens associated with nucleus accumbens, opioid receptor and enkephalin
7) Confidence 0.21 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15872092 Disease Relevance 0.39 Pain Relevance 1.19
To investigate the role of Asp114 in the cloned rat mu-opioid receptor for ligand binding, the charged amino acid was mutated to an asparagine to generate the mutant mu receptor D114N.
Spec (investigate) Regulation (role) of mu-opioid receptor Binding (binding) of associated with opioid receptor
8) Confidence 0.21 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9422382 Disease Relevance 0 Pain Relevance 0.58
Accordingly, we sought to examine whether mu-opioid receptor binding and the receptor-mediated functional coupling to G protein is affected by this drug treatment.
Spec (whether) Regulation (affected) of mu-opioid receptor Spec (whether) Binding (binding) of associated with opioid receptor
9) Confidence 0.21 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15121763 Disease Relevance 0.18 Pain Relevance 0.75
The aim of this work was to investigate the acute and chronic ethanol effects on beta-END content in regions of the mesolimbic system and to examine if chronic ethanol treatment alters ligand binding to mu opioid receptor (muOR).
Spec (examine) Regulation (alters) of mu opioid receptor Spec (examine) Binding (binding) of associated with mu opioid receptor
10) Confidence 0.19 Published 2010 Journal Neuropeptides Section Abstract Doc Link 20031207 Disease Relevance 0 Pain Relevance 0.18
Estrogen modulation of mu-opioid receptor-stimulated [35S]-GTP-gamma-S binding in female rat brain visualized by in vitro autoradiography.
Regulation (modulation) of mu-opioid receptor Binding (binding) of in brain associated with opioid receptor
11) Confidence 0.19 Published 2002 Journal Neuroendocrinology Section Title Doc Link 12411740 Disease Relevance 0.15 Pain Relevance 0.40
With regard to exogenous opioids, the effectiveness of spinal morphine is rapidly enhanced after inflammation, likely to be due to changes in the interaction between the peptide cholecystokinin and the mu opioid receptor.
Regulation (changes) of mu opioid receptor Spec (likely) Binding (interaction) of in spinal associated with inflammation, mu opioid receptor, cholecystokinin, opioid and morphine
12) Confidence 0.18 Published 1995 Journal Inflamm. Res. Section Abstract Doc Link 7583517 Disease Relevance 0.92 Pain Relevance 1.68
The effects of sulfhydryl-specific methanethiosulfonate (MTS) derivatives on mu-opioid receptor binding were examined in Chinese hamster ovary (CHO) cells that stably express mu-opioid receptors (HmuCHO).
Regulation (effects) of mu-opioid receptor Binding (binding) of in ovary associated with mu opioid receptor and opioid receptor
13) Confidence 0.15 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734160 Disease Relevance 0 Pain Relevance 0.30
Continuous intrathecal opioid treatment abolishes the regulatory effects of magnesium and guanine nucleotides on mu opioid receptor binding in rat spinal membranes.
Regulation (effects) of mu opioid receptor Binding (binding) of in spinal associated with narcan, mu opioid receptor, opioid and intrathecal
14) Confidence 0.14 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1320689 Disease Relevance 0.31 Pain Relevance 0.82
In contrast, at the same time when morphine-induced effects on body temperature were assessed, no changes in pertussis toxin-mediated ADP-ribosylation of Gi(alpha)/Go(alpha), or basal adenylate cyclase activity, or binding of mu-opioid receptor selective ligand [3H]-DAMGO were observed in hypothalamic areas from rats treated with cholera toxin.
Neg (no) Regulation (changes) of mu-opioid receptor Binding (binding) of in body associated with bordatella infection, vibrio infection, opioid receptor and morphine
15) Confidence 0.11 Published 1997 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 9077589 Disease Relevance 0.82 Pain Relevance 0.77
Glycosylation resulted in a slight decrease in affinity to the delta-opioid receptor, and mixed effect on binding to the mu-opioid receptor.
Regulation (effect) of mu-opioid receptor Binding (binding) of associated with opioid receptor
16) Confidence 0.11 Published 2000 Journal Brain Res. Section Abstract Doc Link 11033091 Disease Relevance 0.08 Pain Relevance 0.67
We examined the effects of NTB on the specific binding of radiolabeled ligands for opioid mu and kappa2 receptors, and the effects on the release of [3H]norepinephrine ([3H]NE) in rat cerebral cortex slices.
Spec (examined) Regulation (effects) of opioid mu Spec (examined) Binding (ligands) of in cerebral cortex associated with cerebral cortex and opioid
17) Confidence 0.10 Published 2001 Journal Life Sci. Section Abstract Doc Link 11233997 Disease Relevance 0 Pain Relevance 0.39
His223 is critical for mu opioid receptor binding and inactivation by N-ethylmaleimide.
Regulation (critical) of mu opioid receptor Binding (binding) of associated with mu opioid receptor
18) Confidence 0.04 Published 1996 Journal J. Biol. Chem. Section Title Doc Link 8621408 Disease Relevance 0 Pain Relevance 0.10
Thus, these compounds are unsuitable for the investigation of the potential role of protein phosphorylation in the modulation of mu opioid receptor binding.
Regulation (modulation) of mu opioid receptor Binding (binding) of associated with mu opioid receptor
19) Confidence 0.04 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7840778 Disease Relevance 0 Pain Relevance 0.20
It was hypothesised that these results are connected with alterations in dopamine D2 and mu opioid receptor binding.


Regulation (alterations) of mu opioid receptor Binding (binding) of
20) Confidence 0.04 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 18810393 Disease Relevance 0 Pain Relevance 0

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