INT60461

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Context Info
Confidence 0.61
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 40
Total Number 43
Disease Relevance 17.23
Pain Relevance 12.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
alveolar macrophages 5
proximal 4
dental pulp 3
chondrocytes 2
plasma 2
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 577 100.00 Very High Very High Very High
cytokine 435 100.00 Very High Very High Very High
intrathecal 6 99.98 Very High Very High Very High
Hippocampus 25 99.84 Very High Very High Very High
agonist 153 99.66 Very High Very High Very High
electroacupuncture 24 99.58 Very High Very High Very High
trigeminal ganglion 3 98.74 Very High Very High Very High
cINOD 21 98.68 Very High Very High Very High
Snapping jaw 2 98.28 Very High Very High Very High
chemokine 20 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 645 100.00 Very High Very High Very High
Heat Stroke 342 99.98 Very High Very High Very High
Diabetes Mellitus 13 99.84 Very High Very High Very High
Disease 130 99.82 Very High Very High Very High
Cancer 74 99.68 Very High Very High Very High
Necrosis 34 99.44 Very High Very High Very High
Hyperalgesia 20 99.40 Very High Very High Very High
Pressure Volume 2 Under Development 39 99.34 Very High Very High Very High
Stress 62 98.80 Very High Very High Very High
Ganglion Cysts 12 98.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LPS-induced IL-1 alpha gene expression in hippocampus could no longer be detected 30 min after microinjection of Met- or Leu-enkephalin into hippocampus.
Positive_regulation (induced) of Gene_expression (expression) of IL-1 alpha gene in hippocampus associated with enkephalin and hippocampus
1) Confidence 0.61 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9389197 Disease Relevance 0 Pain Relevance 0.84
AIM: To localize interleukin-1 receptor type I (IL-1RI) in rat dental pulp and trigeminal ganglion (TG) and to test the hypothesis that pulpal inflammation increases neuronal expression of IL-1RI.
Positive_regulation (increases) of Gene_expression (expression) of IL-1RI in dental pulp associated with ganglion cysts, inflammation and trigeminal ganglion
2) Confidence 0.57 Published 2009 Journal Int Endod J Section Abstract Doc Link 19732182 Disease Relevance 0.42 Pain Relevance 0.25
Pulpal inflammation significantly increased the expression of IL-1RI in the TG (P < 0.001).
Positive_regulation (increased) of Gene_expression (expression) of IL-1RI
3) Confidence 0.57 Published 2009 Journal Int Endod J Section Body Doc Link 19732182 Disease Relevance 0.11 Pain Relevance 0
The present study demonstrates that intrathecal injection of interleukin-1 (IL-1) in rats at a dose of 50 pg or 500 pg induced a significant hyperalgesic effect in the hot-plate test.
Positive_regulation (induced) of Gene_expression (injection) of IL-1 associated with hyperalgesia and intrathecal
4) Confidence 0.49 Published 2001 Journal Drugs Exp Clin Res Section Abstract Doc Link 11447771 Disease Relevance 0.58 Pain Relevance 0.32
And also EA partly reversed the elevation of IL-1beta and IL-1RI expression induced by carrageenan.
Positive_regulation (elevation) of Gene_expression (expression) of IL-1RI associated with electroacupuncture
5) Confidence 0.42 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19022353 Disease Relevance 0.59 Pain Relevance 1.37
And also EA partly reversed the elevation of IL-1beta and IL-1RI expression induced by carrageenan.
Positive_regulation (induced) of Gene_expression (expression) of IL-1RI associated with electroacupuncture
6) Confidence 0.42 Published 2009 Journal Brain Res. Bull. Section Abstract Doc Link 19022353 Disease Relevance 0.58 Pain Relevance 1.36
is elevated in synovial fluids obtained from TMDs, we hypothesized that IL-1?
Positive_regulation (elevated) of Gene_expression (hypothesized) of IL-1 in synovial fluids
7) Confidence 0.41 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20647497 Disease Relevance 0.70 Pain Relevance 0.44
The results show that enhanced levels of IL-1 in the circulation reflect a stress situation presumably resulting from handling and halothane anesthesia of the animal.
Positive_regulation (enhanced) of Gene_expression (levels) of IL-1 associated with stress, anesthesia and halothane
8) Confidence 0.38 Published 1998 Journal Oncol. Rep. Section Abstract Doc Link 9538175 Disease Relevance 0.10 Pain Relevance 0.14
Neither localized irradiation nor TBI resulted in further enhanced levels of IL-1.
Positive_regulation (enhanced) of Gene_expression (levels) of IL-1
9) Confidence 0.38 Published 1998 Journal Oncol. Rep. Section Abstract Doc Link 9538175 Disease Relevance 0.09 Pain Relevance 0.15
Thus one should consider the time for application of anti-inflammatory drugs, such as cyclooxygenase inhibitor, indomethacin, since it causes increases in TNF alpha and IL-1 production by reducing PGI2 and prostaglandin E2 (PGE2) levels.
Positive_regulation (increases) of Gene_expression (production) of IL-1 associated with inflammation and cinod
10) Confidence 0.36 Published 2000 Journal Yakugaku Zasshi Section Abstract Doc Link 10825809 Disease Relevance 0.90 Pain Relevance 0.49
This conclusion is based on our finding that intravenous injection of IL-1 increases CRF biosynthesis in the PVN, and that lesion of this hypothalamic area interferes with IL-1's stimulatory action on ACTH secretion.
Positive_regulation (increases) of Gene_expression (biosynthesis) of IL-1 in PVN
11) Confidence 0.36 Published 1993 Journal Ciba Found. Symp. Section Abstract Doc Link 8491087 Disease Relevance 0 Pain Relevance 0.18
RESULTS: FR133605 inhibited IL-1 and TNF-alpha production stimulated with lipopolysaccharide (LPS) in human monocytes.
Positive_regulation (stimulated) of Gene_expression (production) of IL-1 in monocytes
12) Confidence 0.26 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8895158 Disease Relevance 0.18 Pain Relevance 0
The levels of TNF-alpha, IL-1 and IL-2 in the serum of AA rats were increased, whereas the level of IL-10 was decreased.
Positive_regulation (increased) of Gene_expression (levels) of IL-1
13) Confidence 0.22 Published 2009 Journal Acta Pharmacol. Sin. Section Body Doc Link 19169271 Disease Relevance 0.21 Pain Relevance 0
These results demonstrate that activation of Kupffer cells with BCG induces impairment of mixed function oxidase system soon as 48 h after injection of activator, probably due to production of IL-1, IL-6 and TNF alpha by activated Kupffer cells and other mononuclear cells migrated to the liver.
Spec (probably) Positive_regulation (induces) of Gene_expression (production) of IL-1 in liver
14) Confidence 0.22 Published 1999 Journal Arq Gastroenterol Section Abstract Doc Link 10751904 Disease Relevance 0.41 Pain Relevance 0.07
AIM: To localize interleukin-1 receptor type I (IL-1RI) in rat dental pulp and trigeminal ganglion (TG) and to test the hypothesis that pulpal inflammation increases neuronal expression of IL-1RI.
Positive_regulation (increases) of in trigeminal ganglion Gene_expression (expression) of IL-1RI in dental pulp associated with ganglion cysts, inflammation and trigeminal ganglion
15) Confidence 0.20 Published 2009 Journal Int Endod J Section Abstract Doc Link 19732182 Disease Relevance 0.42 Pain Relevance 0.25
The expression of IL-1, TNF-alpha and 3-NT protein in the glomeruli were significantly increased in diabetic rats, which were all significantly inhibited by MMF treatment.
Positive_regulation (increased) of Gene_expression (expression) of IL-1 associated with diabetes mellitus
16) Confidence 0.17 Published 2008 Journal Cytokine Section Abstract Doc Link 18725182 Disease Relevance 1.02 Pain Relevance 0.14
Increased production of TNF-alpha and IL-1 in alveolar macrophages was observed in response to SEA and SEB.
Positive_regulation (Increased) of Gene_expression (production) of IL-1 in alveolar macrophages
17) Confidence 0.16 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19375418 Disease Relevance 0 Pain Relevance 0.41
Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1?


Positive_regulation (protects) of Gene_expression (effects) of IL-1 in chondrocytes
18) Confidence 0.16 Published 2006 Journal Arthritis Res Ther Section Title Doc Link PMC1794517 Disease Relevance 0.06 Pain Relevance 0.08
Only the IL-1-enhanced expression of the IL-13 receptor ?
Positive_regulation (enhanced) of Gene_expression (expression) of IL-1
19) Confidence 0.16 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.13 Pain Relevance 0.06
dramatically increased the expression of numerous inflammatory cytokines (IL-1?
Positive_regulation (increased) of Gene_expression (expression) of IL-1 associated with inflammation and cytokine
20) Confidence 0.15 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794517 Disease Relevance 0.10 Pain Relevance 0.19

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