INT60475

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 19
Disease Relevance 4.26
Pain Relevance 5.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a1) enzyme binding (Ugt1a1)
Anatomy Link Frequency
liver 2
spinal cord 2
1A6 1
hypothalamus 1
CAR 1
Ugt1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 27 100.00 Very High Very High Very High
b2 receptor 4 100.00 Very High Very High Very High
Opioid 12 99.76 Very High Very High Very High
Paracetamol 26 99.46 Very High Very High Very High
antagonist 6 96.68 Very High Very High Very High
B1 receptor 6 96.44 Very High Very High Very High
Analgesic 8 96.24 Very High Very High Very High
Hyperalgesia 6 95.08 Very High Very High Very High
Inflammation 88 95.00 High High
Buprenorphine 10 94.08 High High
Disease Link Frequency Relevance Heat
Sprains And Strains 1 99.98 Very High Very High Very High
Periodontitis 60 99.60 Very High Very High Very High
Targeted Disruption 3 99.54 Very High Very High Very High
Chronic Renal Insufficiency 9 99.10 Very High Very High Very High
Hypertension 11 99.04 Very High Very High Very High
Hyperalgesia 6 95.08 Very High Very High Very High
INFLAMMATION 91 95.00 High High
Myocardial Infarction 2 93.68 High High
Poisoning 2 91.56 High High
Ganglion Cysts 1 91.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of B1 and TRPV-1 genes was assessed using real-time polymerase chain reaction.
Gene_expression (expression) of B1
1) Confidence 0.77 Published 2006 Journal Spine Section Body Doc Link 17108828 Disease Relevance 0.14 Pain Relevance 0
Comparison of stably expressed rat UGT1.1 and UGT2B1 in the glucuronidation of opioid compounds.
Gene_expression (expressed) of UGT1 associated with opioid
2) Confidence 0.77 Published 1997 Journal Drug Metab. Dispos. Section Title Doc Link 9029056 Disease Relevance 0.19 Pain Relevance 0.89
The expression of liver UGT1A1 and UGT2B1 did not differ across groups.
Gene_expression (expression) of UGT1A1 in liver
3) Confidence 0.72 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18639530 Disease Relevance 0 Pain Relevance 0.10
Moreover, liver expression of both UGT1A1 and UGT2B1 was studied in the same experimental conditions by polymerase chain reaction analysis.
Gene_expression (expression) of UGT1A1 in liver
4) Confidence 0.72 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18639530 Disease Relevance 0 Pain Relevance 0.19
Five patients were homozygous for the UGT1A1 TA(7) allele, which is associated with reduced UGT1A1 gene expression.
Gene_expression (expression) of UGT1A1 gene
5) Confidence 0.70 Published 2002 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 12185559 Disease Relevance 0.06 Pain Relevance 0
Taken together, these results indicate that nutritional status may gender-specifically influence the expression and activation of CAR and PPARalpha in liver cell nuclei, and this effect appears to be associated with alterations in UGT1A1 and UGT1A6 expression.
Gene_expression (expression) of UGT1A1 in CAR
6) Confidence 0.66 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.26
RESULTS: Greater than twofold increases in the expression of the B1 and TRPV-1 genes were detected in the injured region of the spinal cord in animals exhibiting hyperalgesia compared with animals with SCI that did not display hyperalgesia.
Gene_expression (expression) of B1 in spinal cord
7) Confidence 0.60 Published 2006 Journal Spine Section Body Doc Link 17108828 Disease Relevance 0.12 Pain Relevance 0
In contrast, these compounds were very poor substrates for expressed rat UGT1.1.
Gene_expression (expressed) of UGT1
8) Confidence 0.60 Published 1997 Journal Drug Metab. Dispos. Section Abstract Doc Link 9029056 Disease Relevance 0.13 Pain Relevance 1.19
The striking distribution of B1 receptors on sensory neurones suggests that a direct action of B1 activators on the nervous system may also contribute to hyperalgesia.
Gene_expression (distribution) of B1 in nervous system associated with hyperalgesia
9) Confidence 0.59 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 11072143 Disease Relevance 0.38 Pain Relevance 0.61
There was no significant difference between CRI and CPF rats in hepatic and/or renal E2-3G (UGT1A1), E2-17G (UGT2B3), 4-MUG (UGT1A6), and M3G (UGT2B1) formation.
Gene_expression (formation) of UGT1A1 associated with chronic renal insufficiency and morphine
10) Confidence 0.58 Published 2006 Journal Drug Metab. Dispos. Section Abstract Doc Link 16415115 Disease Relevance 0.61 Pain Relevance 0.27
Stably expressed human and rat phenol UDP-glucuronosyltransferases (UGTs) of the UGT1 complex (HlugP1, HlugP4 and 3-methylcholanthrene-inducible rat UGT1A1, the latter considered to be an orthologous enzyme to HlugP1) have been used to investigate the role of UGTs in paracetamol glucuronidation.
Gene_expression (expressed) of UGT1A1 associated with paracetamol
11) Confidence 0.55 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8494539 Disease Relevance 0 Pain Relevance 0.31
Real-Time PCR was used to determine mRNA levels of UGT1A1, 1A6, 2B1, and 2B3 in the harvested organs.
Spec (determine) Gene_expression (levels) of UGT1A1 in 1A6
12) Confidence 0.54 Published 2008 Journal Drug Metab Lett Section Abstract Doc Link 19356101 Disease Relevance 0.07 Pain Relevance 0.25
CONCLUSION: B1 and TRPV-1 receptor genes are overexpressed in the injured spinal cord of animals manifesting thermal hyperalgesia following SCI compared with similarly injured animals without hyperalgesia.
Gene_expression (overexpressed) of B1 in spinal cord
13) Confidence 0.52 Published 2006 Journal Spine Section Body Doc Link 17108828 Disease Relevance 0 Pain Relevance 0
Messenger RNA and protein levels of UGT1A1 and UGT1A6 in the liver but not the jejunum were increased in male rats fed the HF1 diet.
Gene_expression (levels) of UGT1A1 in jejunum
14) Confidence 0.51 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0
Ourstudy suggests that a subtherapeutic level of PCM may occur in patients who have UGT1A6*2 without UGT1A1*28.
Gene_expression (have) of UGT1A1 associated with paracetamol
15) Confidence 0.33 Published 2007 Journal Pharmacology Section Abstract Doc Link 17164591 Disease Relevance 0.21 Pain Relevance 0.95
Mice deficient in tissue kallikrein, B1 and B2 receptors, some kinin-degrading enzymes, and factor XII followed, together with transgenic rat and mouse strains overexpressing tissue kallikrein, B1 and B2 receptors, and degrading enzymes.
Gene_expression (overexpressing) of B1 associated with targeted disruption and sprains and strains
16) Confidence 0.31 Published 2006 Journal Biol. Chem. Section Abstract Doc Link 16497143 Disease Relevance 0.48 Pain Relevance 0.18
We conclude that B1 and B2 receptor mRNA are differentially expressed in the hypothalamus of SHR and may play different roles in the pathogenesis of hypertension: upregulation of B2 receptor mRNA from early age may participate in the pathogenesis of hypertension, whereas an upregulation of B1 receptor mRNA in the established phase of hypertension may reflect an epiphenomenon in essential hypertension.
Gene_expression (expressed) of B1 in hypothalamus associated with b1 receptor, hypertension and b2 receptor
17) Confidence 0.24 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12025958 Disease Relevance 1.13 Pain Relevance 0.40
Hypericum treatment significantly prevented the periodontitis-mediated NF-kB p65 expression (Figure 3b, b1).
Gene_expression (expression) of b1 associated with periodontitis
18) Confidence 0.15 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.34 Pain Relevance 0
Treatment of rats with Hypericum significantly reduced the ligature-induced inhibition of Bcl-2 expression (Figure 7b, b1).
Gene_expression (expression) of b1
19) Confidence 0.12 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.40 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox