INT605

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 23
Speculated 2
Reported most in Abstract
Documents 61
Total Number 63
Disease Relevance 10.70
Pain Relevance 26.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
striatum 3
spinal 3
NAC 3
cholinergic neurons 3
brain 2
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 87 100.00 Very High Very High Very High
Nucleus accumbens 38 100.00 Very High Very High Very High
opiate 27 100.00 Very High Very High Very High
Pain 22 100.00 Very High Very High Very High
alcohol 19 100.00 Very High Very High Very High
isoflurane 10 100.00 Very High Very High Very High
electroacupuncture 4 100.00 Very High Very High Very High
gABA 11 99.92 Very High Very High Very High
tetrodotoxin 38 99.84 Very High Very High Very High
Dopamine 40 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 17 100.00 Very High Very High Very High
Alzheimer's Dementia 9 100.00 Very High Very High Very High
Body Weight 8 99.70 Very High Very High Very High
Increased Venous Pressure Under Development 92 99.64 Very High Very High Very High
Urological Neuroanatomy 20 99.40 Very High Very High Very High
Shock 2 99.12 Very High Very High Very High
Cognitive Disorder 47 98.24 Very High Very High Very High
Depression 9 98.24 Very High Very High Very High
INFLAMMATION 114 97.76 Very High Very High Very High
Morphine Dependence 2 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Changes in hippocampal Ach and Ch levels were observed in both cognition markedly impaired group and cognition lightly impaired group, accompanied by performance failure in water maze test.
Regulation (Changes) of Ach
1) Confidence 0.62 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20095350 Disease Relevance 0.07 Pain Relevance 0
The separation of ACh, Ch, iso-ACh and related endogenous compounds was carried out based on cation exchange chromatography with a volatile elution buffer consisting of ammonium formate, ammonium acetate and acetonitrile.
Regulation (separation) of ACh
2) Confidence 0.38 Published 2007 Journal J Pharm Biomed Anal Section Abstract Doc Link 17383138 Disease Relevance 0.16 Pain Relevance 0.04
OBJECTIVE: To examine the effect of acetylcholine (ACh) on the electric activities of pain-excitation neurons (PEN) and pain-inhibitation neurons (PIN) in the hippocampal CA1 area of normal rats or morphinistic rats, and to explore the role of ACh in regulation of pain perception in CA1 area under normal condition and morphine addiction.
Regulation (role) of ACh in neurons associated with addiction, pain and morphine
3) Confidence 0.37 Published 2007 Journal Neuroscience bulletin Section Abstract Doc Link 18064061 Disease Relevance 0.47 Pain Relevance 0.52
Therefore the effects of acute and chronic alcohol (1 gm/kg/day i.p.) treatment on extracellular concentrations of NAc ACh and DA were determined before and after naloxone-precipitated withdrawal.
Regulation (effects) of ACh in NAc associated with nucleus accumbens, dopamine, narcan, withdrawal and alcohol
4) Confidence 0.36 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15582668 Disease Relevance 0.07 Pain Relevance 1.23
The separation of ACh, Ch, iso-ACh and related endogenous compounds was carried out based on cation exchange chromatography with a volatile elution buffer consisting of ammonium formate, ammonium acetate and acetonitrile.
Regulation (separation) of ACh
5) Confidence 0.33 Published 2007 Journal J Pharm Biomed Anal Section Abstract Doc Link 17383138 Disease Relevance 0.16 Pain Relevance 0.04
Several opiate agents were tested for their ability to modulate ACh release evoked by potassium ions (K+) or glutamic acid (GLU).
Regulation (modulate) of ACh associated with opiate
6) Confidence 0.32 Published 1990 Journal Brain Res. Section Abstract Doc Link 1976420 Disease Relevance 0 Pain Relevance 1.21
The activation of kappa-opiate receptor by dynorphin-(1-13) had no effect on K(+)- or GLU-evoked ACh release.
Neg (no) Regulation (effect) of ACh associated with dynorphin and opiate
7) Confidence 0.32 Published 1990 Journal Brain Res. Section Abstract Doc Link 1976420 Disease Relevance 0 Pain Relevance 1.72
In contrast, addition of the same concentration range of ginkgolide A (GKA, 0.01-10 micro M) had no effect on beta-amyloid-inhibited ACh release.
Neg (no) Regulation (effect) of ACh associated with alzheimer's dementia
8) Confidence 0.31 Published 2004 Journal Phytother Res Section Abstract Doc Link 15305316 Disease Relevance 0.69 Pain Relevance 0.09
Investigation of the effects of JTP-2942 (0.001-1 mM) and TRH (1 and 10 mM) on ACh release and choline levels when perfused through the dialysis probe revealed that JTP-2942 had a greater effect than TRH in both the frontal cortex and the hippocampus.
Regulation (effects) of ACh in hippocampus associated with urological neuroanatomy and hippocampus
9) Confidence 0.28 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8472746 Disease Relevance 0.56 Pain Relevance 0.23
The ACh esterase inhibitor physostigmine (1 microM) exhibited significant inhibitory effects from P13 onwards, whereas the muscarinic antagonist atropine (1 microM) did not change the evoked ACh release.
Neg (not) Regulation (change) of ACh associated with antagonist
10) Confidence 0.27 Published 1999 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 10209237 Disease Relevance 0 Pain Relevance 0.20
In addition, during acupuncture (applied at acupoint "Huantiao") analgesia, no apparent changes of Ach content can be visualized in spinal ganglia, however, the level of AchE activity goes up evidently.
Neg (no) Regulation (changes) of Ach in spinal associated with acupuncture and analgesia
11) Confidence 0.26 Published 1989 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 2517610 Disease Relevance 0.07 Pain Relevance 0.27
Effects of novelty and pain on behavior and hippocampal extracellular ACh levels in male and female rats.
Regulation (Effects) of ACh associated with pain
12) Confidence 0.24 Published 1999 Journal Brain Res. Section Title Doc Link 9878722 Disease Relevance 0.20 Pain Relevance 0.43
On Day 1 the raw values of ACh were higher in females than in males, but no sex difference was present when the percentage of change was considered.
Regulation (values) of ACh
13) Confidence 0.24 Published 1999 Journal Brain Res. Section Abstract Doc Link 9878722 Disease Relevance 0.20 Pain Relevance 0.25
Basal ACh was sensitive to tetrodotoxin and low calcium, and therefore largely neuronal in origin.
Regulation (sensitive) of ACh in neuronal associated with tetrodotoxin
14) Confidence 0.24 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1573406 Disease Relevance 0 Pain Relevance 0.64
The effects on ACh in the NAC and STR were also observed in response to water intake in 20-h water-deprived animals.
Regulation (effects) of ACh in STR associated with nucleus accumbens
15) Confidence 0.24 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1573406 Disease Relevance 0 Pain Relevance 0.60
The regulation of acetylcholine (ACh) release from cholinergic neurons transplanted to the hippocampus or neocortex was studied by microdialysis in awake rats.
Regulation (regulation) of ACh in cholinergic neurons associated with hippocampus
16) Confidence 0.24 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239294 Disease Relevance 0.14 Pain Relevance 0.19
The results indicate that the effects of morphine and nalorphine on brain ACh levels varied depending upon the time of administration.
Regulation (effects) of ACh in brain associated with morphine
17) Confidence 0.24 Published 1982 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7181581 Disease Relevance 0 Pain Relevance 0.45
For instance, 10 mg/kg of morphine did not significantly change total brain ACh when injected in the morning whereas a 45% increase in ACh level was observed after administration of the same dose at night.
Neg (not) Regulation (change) of ACh in brain associated with morphine
18) Confidence 0.24 Published 1982 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7181581 Disease Relevance 0 Pain Relevance 0.46
ACh content was not affected in any region studied.
Neg (not) Regulation (affected) of ACh
19) Confidence 0.24 Published 1991 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1786642 Disease Relevance 0.07 Pain Relevance 0.49
Moreover, ACh levels did not change following acute SC transection performed under anesthesia during ongoing dialysis, suggesting an intrinsic source for spinal ACh.
Neg (not) Regulation (change) of ACh in spinal associated with anesthesia and spinal cord
20) Confidence 0.24 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17234186 Disease Relevance 0 Pain Relevance 0.47

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