INT6050

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Context Info
Confidence 0.68
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.53
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
plasma 1
sinus 1
nucleus 1
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 6 98.28 Very High Very High Very High
Nucleus accumbens 54 97.44 Very High Very High Very High
medulla 4 95.84 Very High Very High Very High
Eae 16 95.68 Very High Very High Very High
nMDA receptor antagonist 1 91.68 High High
cocaine 107 91.56 High High
Pain 4 87.76 High High
Glutamate receptor 3 84.88 Quite High
Neuropeptide 6 84.04 Quite High
adenocard 3 32.40 Quite Low
Disease Link Frequency Relevance Heat
Aids-related Complex 25 100.00 Very High Very High Very High
Peripheral Arterial Disease 2 96.40 Very High Very High Very High
Osteogenic Sarcomas 2 82.88 Quite High
Cocaine Dependence 10 5.00 Very Low Very Low Very Low
Recurrence 8 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Cognitive Disorder 3 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Drug Dependence 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Messenger RNA encoding the immediate early genes (IEGs) c-fos and NGFI-A was localized by in situ hybridization of specific 35S-labelled oligonucleotides to detect activated neurones in the medulla oblongata following unilateral electrical stimulation of the vagus (nX) and aortic depressor nerve (ADN), and following mechanical stimulation of the left carotid sinus (CS).
Localization (localized) of NGFI-A in sinus associated with medulla
1) Confidence 0.68 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1320720 Disease Relevance 0 Pain Relevance 0.09
Furthermore, the co-localization of formalin injection-evoked Zif/268 and c-Fos expression and subunit 1 of the NMDA receptor (NR1) was studied in this nucleus.
Localization (localization) of Zif/268 in nucleus associated with nmda receptor
2) Confidence 0.66 Published 2003 Journal Brain Res. Bull. Section Abstract Doc Link 14596893 Disease Relevance 0.17 Pain Relevance 0.35
Category 1 changes in CART, NPY (both increased at 1-day) and Egr1 (decreased at 1-day) in the mPFC were also confirmed by qPCR (Table 2).


Localization (decreased) of Egr1
3) Confidence 0.51 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.26 Pain Relevance 0.22
The regional, normalized homer1a, arc, zif268, ngfi-b, and c-fos expression measurements were used to calculate Pearson product moment correlations with locomotor activity, plasma corticosterone, and gene expression in other regions within the water and Ensure cues groups.
Localization (normalized) of zif268 in plasma associated with aids-related complex and eae
4) Confidence 0.50 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

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