INT6051

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Context Info
Confidence 0.69
First Reported 1991
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 27
Total Number 31
Disease Relevance 6.30
Pain Relevance 11.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
nucleus 10
spinal cord 4
barrel cortex 4
insular cortex 2
liver 2
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 54 100.00 Very High Very High Very High
isoflurane 5 100.00 Very High Very High Very High
fluoxetine 11 99.98 Very High Very High Very High
qutenza 89 99.80 Very High Very High Very High
Nicotine 20 99.74 Very High Very High Very High
Spinal cord 56 99.68 Very High Very High Very High
Locus ceruleus 15 99.68 Very High Very High Very High
agonist 16 99.66 Very High Very High Very High
intrathecal 7 99.32 Very High Very High Very High
withdrawal 10 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 228 99.84 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

42 99.08 Very High Very High Very High
Injury 9 98.32 Very High Very High Very High
Neuropathic Pain 5 96.32 Very High Very High Very High
INFLAMMATION 18 95.92 Very High Very High Very High
Depression 7 94.48 High High
Pain 44 91.52 High High
Colitis 6 84.40 Quite High
Sleep Disorders 30 82.72 Quite High
Nociception 16 81.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both opiate and alpha2-adrenoceptor agonists reduced formalin-induced c-fos gene transcription and nocifensive behavior via their cognate receptors.
Positive_regulation (-) of Transcription (transcription) of c-fos gene associated with agonist and opiate
1) Confidence 0.69 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10497900 Disease Relevance 0.08 Pain Relevance 0.86
Surprisingly, both lower and higher doses of propofol resulted in a non-significant, but sub-maximal induction of c-Fos transcription 24% ± 9% (P = 0.073, N = 3) and 43% ± 7% (P = 0.065, N = 3) increase for 5.6 ?
Positive_regulation (induction) of Transcription (transcription) of c-Fos
2) Confidence 0.67 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
It is hypothesized that the gastric acid-induced c-fos transcription in the brainstem is related to gastric chemonociception.


Positive_regulation (induced) of Transcription (transcription) of c-fos in brainstem
3) Confidence 0.67 Published 1998 Journal Gastroenterology Section Body Doc Link 9721162 Disease Relevance 0 Pain Relevance 0
RESULTS: Gastric acid challenge did not induce c-fos transcription in the spinal cord but caused many neurons in the nucleus tractus solitarii and area postrema to express c-fos messenger RNA (mRNA).
Neg (not) Positive_regulation (induce) of Transcription (transcription) of c-fos in nucleus
4) Confidence 0.67 Published 1998 Journal Gastroenterology Section Body Doc Link 9721162 Disease Relevance 0 Pain Relevance 0
However, c-fos transcription in the insular cortex was not enhanced by the gastric acid insult.
Neg (not) Positive_regulation (enhanced) of Transcription (transcription) of c-fos in insular cortex
5) Confidence 0.67 Published 2001 Journal Pain Section Abstract Doc Link 11323123 Disease Relevance 0.07 Pain Relevance 0.23
In this setting,NO2-Arg-Trim but not trimebutine, significantly down-regulated the spinal cFOS mRNA expression and increased blood concentrations of NO2 +NO3.
Positive_regulation (increased) of Transcription (expression) of cFOS in spinal
6) Confidence 0.49 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 19416632 Disease Relevance 1.16 Pain Relevance 1.09
M propofol resulted in a significantly lower c-Fos (49% ± 12%; P = 0.024, N = 3) and higher Egr-1 (39% ± 7%; P = 0.046, N = 3) gene transcription compared to propofol treatment alone.
Positive_regulation (resulted) of Transcription (transcription) of c-Fos
7) Confidence 0.49 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
Additionally, repeated administrations of nicotine transiently induced the c-fos and c-jun mRNA levels after the first-third nicotine administration, and the c-fos and c-jun mRNA levels were returned to the basal level after the seventh administration of nicotine. c-Fos, c-Jun and Fra-2 protein levels were persistently increased until the seventh administration.
Positive_regulation (returned) of Transcription (levels) of c-fos associated with nicotine
8) Confidence 0.49 Published 2002 Journal Life Sci. Section Abstract Doc Link 12269402 Disease Relevance 0 Pain Relevance 0.48
The sciatic nerve and the lumbar tract of the spinal cord were processed to evaluate the levels of the phosphorylated form of PKCgamma, ERK 1,2, SAP/JNK, p-38 and c-Jun; furthermore, the mRNA expression of the early genes c-Jun and c-Fos has been investigated.
Spec (investigated) Positive_regulation (investigated) of Transcription (expression) of c-Fos in spinal cord associated with sciatic nerve and spinal cord
9) Confidence 0.49 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.57 Pain Relevance 0.60
Fluoxetine induces the transcription of genes encoding c-fos, corticotropin-releasing factor and its type 1 receptor in rat brain.
Positive_regulation (induces) of Transcription (transcription) of c-fos in brain associated with fluoxetine
10) Confidence 0.49 Published 1998 Journal Neuroscience Section Title Doc Link 9740405 Disease Relevance 0.09 Pain Relevance 0.60
In addition, PMA caused the induction of c-fos, c-jun and fra-1 mRNA level and, especially, PMA-induced increase of fra-1 mRNA level was further enhanced by CHX treatment at 4 h.
Positive_regulation (induction) of Transcription (level) of c-fos
11) Confidence 0.49 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0
M) propofol caused a 80% induction in c-Fos transcription, and a 91% decrease in the transcription of Egr-1.
Positive_regulation (induction) of Transcription (transcription) of c-Fos
12) Confidence 0.49 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.05
Both opiate and alpha2-adrenoceptor agonists reduced formalin-induced c-fos gene transcription and nocifensive behavior via their cognate receptors.
Positive_regulation (induced) of Transcription (transcription) of c-fos gene associated with agonist and opiate
13) Confidence 0.47 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10497900 Disease Relevance 0.08 Pain Relevance 0.86
Kozinn and co-workers demonstrated that lower concentrations of propofol inhibits N-methyl-D-aspartate (NMDA) receptor activation of MAPK/ERK pathway and c-Fos transcription in hippocampal neurons[14].
Positive_regulation (activation) of Transcription (transcription) of c-Fos in neurons
14) Confidence 0.45 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0.06 Pain Relevance 0.06
Recently we have also demonstrated that propofol induces a time and dose dependant transcription of the IEGs c-Fos and Egr-1 in neuronal cells[17].
Positive_regulation (induces) of Transcription (transcription) of c-Fos in neuronal
15) Confidence 0.45 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0.07 Pain Relevance 0.22
In summary, we demonstrated that propofol induces a time and dose dependant transcription of IEGs c-Fos and Egr-1 in rat hippocampal slices.
Positive_regulation (induces) of Transcription (transcription) of c-Fos
16) Confidence 0.45 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0.06 Pain Relevance 0.14
Relative to vehicle, HCl (0.5 M) and capsaicin (3.2 mM) increased c-fos transcription in the nucleus tractus solitarii by factors of 7.0 and 2.1, respectively.
Positive_regulation (increased) of Transcription (transcription) of c-fos in nucleus associated with qutenza
17) Confidence 0.45 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1239919 Disease Relevance 0.19 Pain Relevance 1.02
In contrast, mRNA levels for c-fos were dramatically elevated in the LC following naloxone-precipitated withdrawal.
Positive_regulation (elevated) of Transcription (levels) of c-fos associated with locus ceruleus, narcan and withdrawal
18) Confidence 0.45 Published 1995 Journal Synapse Section Abstract Doc Link 7540319 Disease Relevance 0.07 Pain Relevance 1.64
Lower levels of c-fos and NGFI-A mRNA were seen in the ipsilateral NTS and PTN following mechanical stimulation of the left CS.
Positive_regulation (following) of Transcription (levels) of c-fos in PTN
19) Confidence 0.45 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1320720 Disease Relevance 0 Pain Relevance 0.11
Additionally, repeated administrations of nicotine transiently induced the c-fos and c-jun mRNA levels after the first-third nicotine administration, and the c-fos and c-jun mRNA levels were returned to the basal level after the seventh administration of nicotine. c-Fos, c-Jun and Fra-2 protein levels were persistently increased until the seventh administration.
Positive_regulation (induced) of Transcription (levels) of c-fos associated with nicotine
20) Confidence 0.45 Published 2002 Journal Life Sci. Section Abstract Doc Link 12269402 Disease Relevance 0 Pain Relevance 0.47

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