INT6052

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 8.40
Pain Relevance 6.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ptn) endoplasmic reticulum (Ptn)
Anatomy Link Frequency
DRG 3
neuronal 1
spinal cord 1
natural killer cell 1
Schwann cells 1
Ptn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 7 99.86 Very High Very High Very High
Neuropathic pain 18 99.84 Very High Very High Very High
Spinal cord 13 99.68 Very High Very High Very High
cytokine 8 99.58 Very High Very High Very High
Pain 7 99.58 Very High Very High Very High
Eae 30 98.96 Very High Very High Very High
Morphine 6 98.24 Very High Very High Very High
Sciatic nerve 24 96.08 Very High Very High Very High
allodynia 6 95.88 Very High Very High Very High
opioid receptor 5 93.48 High High
Disease Link Frequency Relevance Heat
Vomiting 6 100.00 Very High Very High Very High
Neuropathic Pain 24 99.84 Very High Very High Very High
Sprains And Strains 36 99.64 Very High Very High Very High
Injury 30 98.96 Very High Very High Very High
Neuroblastoma 1 98.24 Very High Very High Very High
Nervous System Injury 12 96.68 Very High Very High Very High
Breast Cancer 1 75.48 Quite High
Adhesions 8 72.00 Quite High
Pain 1 60.16 Quite High
Gliosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain.
Gene_expression (expression) of pleiotrophin gene associated with neuropathic pain, sprains and strains and cytokine
1) Confidence 0.78 Published 2008 Journal Growth Factors Section Title Doc Link 18365878 Disease Relevance 1.24 Pain Relevance 0.75
Real time RT-PCR revealed minimal changes in PTN/MK gene expression in the spinal cord after CCI despite the strain considered, but marked changes were detected in DRG.
Gene_expression (expression) of PTN in DRG associated with eae, sprains and strains and spinal cord
2) Confidence 0.78 Published 2008 Journal Growth Factors Section Abstract Doc Link 18365878 Disease Relevance 1.35 Pain Relevance 0.64
We have tested this hypothesis by comparatively studying PTN and MK gene expression in the spinal cord and dorsal root ganglia (DRG) of three rat strains known to differ in their behavioural responses to chronic constriction injury (CCI) of the sciatic nerve: Lewis, Fischer 344 (F344) and Sprague-Dawley (SD).
Gene_expression (expression) of PTN in dorsal root ganglia associated with eae, injury, sciatic nerve, sprains and strains and spinal cord
3) Confidence 0.78 Published 2008 Journal Growth Factors Section Abstract Doc Link 18365878 Disease Relevance 1.18 Pain Relevance 0.60
A significant upregulation of PTN gene expression occurred in injured DRG of the F344 strain, the only strain that recovers from CCI-induced mechanical allodynia 28 days after surgery.
Gene_expression (expression) of PTN in DRG associated with allodynia, eae and sprains and strains
4) Confidence 0.78 Published 2008 Journal Growth Factors Section Abstract Doc Link 18365878 Disease Relevance 1.38 Pain Relevance 0.67
Different pattern of pleiotrophin and midkine expression in neuropathic pain: correlation between changes in pleiotrophin gene expression and rat strain differences in neuropathic pain.
Gene_expression (expression) of pleiotrophin associated with neuropathic pain, sprains and strains and cytokine
5) Confidence 0.75 Published 2008 Journal Growth Factors Section Title Doc Link 18365878 Disease Relevance 1.19 Pain Relevance 0.73
These findings suggest that experience of chemotherapy infusions is an important source of expectations for PTN, which may be representative of the source of expectations for nonvolitional outcomes in broader contexts.
Gene_expression (source) of PTN associated with vomiting
6) Confidence 0.60 Published 2003 Journal Ann Behav Med Section Abstract Doc Link 12581936 Disease Relevance 0.65 Pain Relevance 0.06
In general these data correlate with the topography of innervation by the different nerve afferents, although the expression in the PTN (and in some cases the AP) would not be predicted on the basis of neuronal innervation patterns reported for the rat.
Gene_expression (expression) of PTN in neuronal
7) Confidence 0.53 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1320720 Disease Relevance 0 Pain Relevance 0.12
Pleiotrophin gene expression was not altered by any treatment; however midkine mRNA levels were increased after chronic treatment with morphine.
Gene_expression (expression) of Pleiotrophin gene associated with morphine
8) Confidence 0.48 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17157293 Disease Relevance 0 Pain Relevance 0.91
FGF-2 and its high affinity receptor [39], as well as HB-GAM [40], are expressed by Schwann cells.
Gene_expression (expressed) of HB-GAM in Schwann cells
9) Confidence 0.29 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC293377 Disease Relevance 0.24 Pain Relevance 0
We have tested this hypothesis by comparatively studying PTN and MK gene expression in the spinal cord and dorsal root ganglia (DRG) of three rat strains known to differ in their behavioural responses to chronic constriction injury (CCI) of the sciatic nerve: Lewis, Fischer 344 (F344) and Sprague-Dawley (SD).
Gene_expression (expression) of PTN in spinal cord associated with eae, injury, sciatic nerve, sprains and strains and spinal cord
10) Confidence 0.26 Published 2008 Journal Growth Factors Section Abstract Doc Link 18365878 Disease Relevance 1.18 Pain Relevance 0.60
Second, across the cycle of posture-related corrections, bicuculline affected PTN responses not uniformly but in a strong phase-dependent manner, being maximal in the period of higher PTN activity.
Gene_expression (responses) of PTN
11) Confidence 0.19 Published 2007 Journal The European Journal of Neuroscience Section Body Doc Link PMC2777253 Disease Relevance 0 Pain Relevance 0.18
Immune assessments completed 1 h following drug administration showed that the mu-receptor selective agonist DAMGO produced a dose-dependent decrease in natural killer cell activity and T-lymphocyte proliferation to the mitogen concanavalin A (Con A); no immunological changes were found following DPDPE or U69,593 treatment.
Gene_expression (produced) of mitogen in natural killer cell associated with agonist
12) Confidence 0.03 Published 2000 Journal Brain Behav. Immun. Section Abstract Doc Link 10970678 Disease Relevance 0 Pain Relevance 1.24

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