INT60526

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 12
Speculated 7
Reported most in Body
Documents 449
Total Number 456
Disease Relevance 292.71
Pain Relevance 107.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
monocytes 32
T cells 32
plasma 27
macrophages 17
chondrocytes 12
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 10449 100.00 Very High Very High Very High
Inflammation 8183 100.00 Very High Very High Very High
rheumatoid arthritis 1642 100.00 Very High Very High Very High
chemokine 1325 100.00 Very High Very High Very High
antagonist 823 100.00 Very High Very High Very High
Inflammatory mediators 360 100.00 Very High Very High Very High
intrathecal 29 99.98 Very High Very High Very High
IPN 19 99.86 Very High Very High Very High
Osteoarthritis 1207 99.84 Very High Very High Very High
Inflammatory response 1051 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 9596 100.00 Very High Very High Very High
Cancer 3067 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 1915 100.00 Very High Very High Very High
Rheumatoid Arthritis 1681 100.00 Very High Very High Very High
Sepsis 1232 100.00 Very High Very High Very High
Necrosis 644 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 143 100.00 Very High Very High Very High
Urological Neuroanatomy 30 100.00 Very High Very High Very High
Infection 3253 99.96 Very High Very High Very High
Targeted Disruption 422 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The A allele of -592 C>A and the T allele of -819 C>T have previously been linked to a lower expression IL-10 mRNA.18 Our results confirm that the 1170 C>T and linked polymorphisms, but not the -1082 G>A or other SNPs in our study, are genetic markers of in vivo IL-10 production.
Gene_expression (production) of IL-10
1) Confidence 0.78 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.55 Pain Relevance 0.04
Additionally, we included rs1800872 of IL10 (5' UTR) that lies within the putative STAT 3 binding site and has been associated with IL-10 expression [21,22].
Gene_expression (expression) of IL-10
2) Confidence 0.77 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 0 Pain Relevance 0
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.
Gene_expression (production) of interleukin-10 in spinal associated with pain, inflammation and cytokine
3) Confidence 0.76 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 15869510 Disease Relevance 1.04 Pain Relevance 1.46
Interestingly, the amount of IL10-producing Tr1 cells, shown to be critical for the control of “determinant spreading“ during chronic immune responses [27], was found drastically reduced in TLT.
Gene_expression (producing) of IL10 in Tr1 cells
4) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894881 Disease Relevance 0.09 Pain Relevance 0.05
M. vaccae administration has also been shown to facilitate the development of Treg cells that can downregulate Th2 immune responses via production of interleukin-10 (IL-10) and transforming growth factor-?
Gene_expression (production) of interleukin-10
5) Confidence 0.75 Published 2007 Journal Neuroscience Section Body Doc Link PMC1868963 Disease Relevance 0.20 Pain Relevance 0.12
Muscle soreness (MS), lactate dehydrogenase (LDH) activity, lipid peroxidation, protein carbonylation, tumor necrosis factor-alpha (TNF-alpha), and interleukin 10 (IL-10) levels were determined.
Gene_expression (levels) of interleukin 10 in Muscle associated with necrosis, cancer and myalgia
6) Confidence 0.72 Published 2010 Journal J Physiol Sci Section Abstract Doc Link 19859781 Disease Relevance 0.64 Pain Relevance 0.10
Muscle soreness (MS), lactate dehydrogenase (LDH) activity, lipid peroxidation, protein carbonylation, tumor necrosis factor-alpha (TNF-alpha), and interleukin 10 (IL-10) levels were determined.
Gene_expression (levels) of IL-10 in Muscle associated with necrosis, cancer and myalgia
7) Confidence 0.72 Published 2010 Journal J Physiol Sci Section Abstract Doc Link 19859781 Disease Relevance 0.64 Pain Relevance 0.10
The strong association between elevation of IL-10 and future events was significantly weakened only after adjustment for CRP and IL-6, which suggests that IL-10 holds similarly detailed prognostic information as other biomarkers of inflammation.
Gene_expression (elevation) of IL-10 associated with inflammation
8) Confidence 0.67 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.47 Pain Relevance 0.08
Haplotype analysis of the IL10, IL19, IL20, and IL24 genes was performed according to the pairwise linkage disequilibrium pattern observed within each of these genes (cases + controls, n = 429).
Gene_expression (analysis) of IL10
9) Confidence 0.67 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2648955 Disease Relevance 0.28 Pain Relevance 0
We studied three SNPs (IL10-1087, -824, and -597) and two microsatellites (IL10R and IL10G) lying within the promoter region of IL10 for association with susceptibility to and clinical manifestations of ankylosing spondylitis (AS), a common form of spondyloarthritis.
Gene_expression (studied) of IL10 associated with spinal inflammation
10) Confidence 0.65 Published 2003 Journal Genes Immun. Section Abstract Doc Link 12595905 Disease Relevance 0.62 Pain Relevance 0.41
, IL-6, and IL-10 were determined by ELISA (Pierce Endogen, Rockford, Illinois, United States).
Spec (determined) Gene_expression (determined) of IL-10
11) Confidence 0.65 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1522038 Disease Relevance 0.31 Pain Relevance 0.13
, IL-10, LPS, and MPO levels.


Gene_expression (levels) of IL-10 associated with urological neuroanatomy
12) Confidence 0.65 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1522038 Disease Relevance 0.36 Pain Relevance 0.20
Plasma concentrations of epinephrine, norepinephrine, cortisol, IL-6 and IL-10 as well as monocyte surface expression of HLA-DR and their ex vivo capacity to release TNF-alpha after LPS stimulation were measured perioperatively.
Gene_expression (expression) of IL-10 in Plasma
13) Confidence 0.63 Published 2003 Journal Cytokine Section Abstract Doc Link 14609565 Disease Relevance 0.34 Pain Relevance 0.52
Two cytokines IL-2 and IL-10, which are specific pattern of lymphocytes T helper 1 and T helper 2, respectively, were produced in the bioreactor up to 14 days of culture.
Gene_expression (produced) of IL-10 in lymphocytes associated with cytokine
14) Confidence 0.63 Published 2007 Journal J. Biotechnol. Section Abstract Doc Link 17905461 Disease Relevance 0.07 Pain Relevance 0.18
During the last months of pregnancy Treg lymphocytes level is elevated leading to overexpression of IL-4 and IL-10.
Gene_expression (overexpression) of IL-10 in lymphocytes
15) Confidence 0.62 Published 2008 Journal Presse Med Section Abstract Doc Link 18819772 Disease Relevance 0.72 Pain Relevance 0.31
The gene expressions of hyaluronan synthase-1, hyaluronan synthase-2, and interleukin-10 which is an antiadhesive cytokine were predominant in nonadhesive bursae.
Gene_expression (expressions) of interleukin-10 associated with cytokine
16) Confidence 0.62 Published 2003 Journal Clin. Orthop. Relat. Res. Section Abstract Doc Link 12838053 Disease Relevance 0.31 Pain Relevance 0.16
Interestingly, exposure to a lower concentration (1 microM) of the antidepressants tended to increase T-cell-derived IL-10 production, with significant effects elicited by the noradrenaline reuptake inhibitors reboxetine and desipramine.
Gene_expression (production) of IL-10 in T-cell associated with desipramine, antidepressant and noradrenaline
17) Confidence 0.61 Published 2006 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 16388933 Disease Relevance 0.18 Pain Relevance 1.00
None of the peptides included in the study were able to induce statistically significant differences in the expression level of IL4, IL10 and TGF® when cytokines were analyzed individually.
Gene_expression (expression) of IL10 associated with cytokine
18) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.37 Pain Relevance 0.23
Experimental studies have indicated that sampling time may considerably influence IL-10 measurements; IL-10 production was delayed in a study of patients measured before and after percutaneous coronary intervention and in vitro the production of IL-10 in lipopolysacharide-stimulated monocytes is delayed compared with that of interleukin-1?
Gene_expression (production) of IL-10 in monocytes
19) Confidence 0.60 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.65 Pain Relevance 0.10
Our primary results poorly support previous smaller reports associating lower serum IL-10 levels with elevation of CRP, unstable angina or an unfavourable prognosis in patients with ACS.12–15 Of note, our study consisted of 3634 individuals with available plasma IL-10 determinations and is thus several-fold larger than any previous study on this topic.
Gene_expression (levels) of IL-10 in plasma associated with acute coronary syndrome and angina
20) Confidence 0.60 Published 2008 Journal Heart Section Body Doc Link PMC2564840 Disease Relevance 0.76 Pain Relevance 0.15

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