INT60527

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Context Info
Confidence 0.56
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 13.57
Pain Relevance 6.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
T cell 2
joint 1
sciatic nerves 1
brains 1
peripheral nervous system 1
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 393 100.00 Very High Very High Very High
Inflammation 316 100.00 Very High Very High Very High
Sciatic nerve 4 99.84 Very High Very High Very High
Neuritis 23 99.62 Very High Very High Very High
antagonist 10 99.00 Very High Very High Very High
corticosteroid 20 98.88 Very High Very High Very High
Peripheral nervous system 8 98.48 Very High Very High Very High
rheumatoid arthritis 213 98.12 Very High Very High Very High
chemokine 41 96.48 Very High Very High Very High
cINOD 17 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 340 100.00 Very High Very High Very High
Experimental Autoimmune Neuritis 22 99.62 Very High Very High Very High
Blister 2 99.52 Very High Very High Very High
Infection 159 99.40 Very High Very High Very High
Disease 226 98.76 Very High Very High Very High
Rheumatoid Arthritis 214 98.12 Very High Very High Very High
Malaria 90 97.28 Very High Very High Very High
Erythema 2 95.88 Very High Very High Very High
Autoimmune Disease 33 95.80 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 17 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression pattern of IL4, IL10 and TGF® mRNA levels was analyzed following peptide-specific stimulation.
Transcription (levels) of IL10
1) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.29 Pain Relevance 0.16
Past and chronic infections are associated with a higher level of COX-2 and IL-10 mRNA
Transcription (level) of IL-10 associated with infection
2) Confidence 0.43 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 1.67 Pain Relevance 0
The levels of IL-10 transcripts were higher in PfHRP2+-placentas than in controls (MW p = 0.004, Figure 1A) and correlated with COX-2 expression (n = 54, SP p = 0.006 R = 0.36; and p = 0.008 R = 0.36).
Transcription (transcripts) of IL-10 in placentas
3) Confidence 0.33 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 1.29 Pain Relevance 0
These data indicate that low amount of pigment was associated with the highest levels of COX-2 and IL-10 transcripts, whereas, high amount of HZ was associated with a lower COX-2 expression.
Transcription (levels) of IL-10
4) Confidence 0.33 Published 2010 Journal Malar J Section Body Doc Link PMC2831904 Disease Relevance 0.70 Pain Relevance 0.03
Three, 6, and 24 h after irradiation, the proopiomelanocortin and interleukin-10 mRNA levels in suction blister induced epidermal sheets were considerably upregulated as detected by semiquantitative reverse transcription-polymerase chain reaction.
Transcription (levels) of interleukin-10 associated with blister
5) Confidence 0.31 Published 2004 Journal J. Invest. Dermatol. Section Abstract Doc Link 15009732 Disease Relevance 0.49 Pain Relevance 0.34
Cytokine dichotomy in peripheral nervous system influences the outcome of experimental allergic neuritis: dynamics of mRNA expression for IL-1 beta, IL-6, IL-10, IL-12, TNF-alpha, TNF-beta, and cytolysin.
Transcription (expression) of IL-10 in peripheral nervous system associated with peripheral nervous system, experimental autoimmune neuritis, neuritis and cytokine
6) Confidence 0.31 Published 1997 Journal Clin. Immunol. Immunopathol. Section Title Doc Link 9191887 Disease Relevance 1.37 Pain Relevance 1.29
IL-10 and IL-2 messenger RNAs were undetectable in all brains examined.
Transcription (undetectable) of IL-10 in brains
7) Confidence 0.31 Published 1993 Journal Ann. Neurol. Section Abstract Doc Link 8498837 Disease Relevance 1.87 Pain Relevance 0.26
On the contrary, transcription of cytolysin and IL-10 in sciatic nerves reached maxima during clinical improvement of EAN.
Transcription (transcription) of IL-10 in sciatic nerves associated with sciatic nerve and neuritis
8) Confidence 0.30 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9191887 Disease Relevance 1.31 Pain Relevance 1.26
Other receptors include class II receptors that bind the interferon and IL10 families, the immunoglobulin superfamily receptors that bind the IL1 cytokine family, TNF family receptors, TGF?
Transcription (receptors) of IL10 associated with cytokine
9) Confidence 0.26 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.13 Pain Relevance 0.61
We have also studied cytokines associated with the function of Th2 (IL-4 and IL-10) and Th1 (IL-2, IL-12 (p70), and INF?)
Transcription (function) of IL-10 associated with cytokine
10) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.18 Pain Relevance 0.75
Corticosteroids may also control airway inflammation by increasing the transcription of anti-inflammatory genes like IL-10, IL-12 or IL-1 receptor antagonist, the gene products of which appear to be the most potent anti-inflammatory drugs for use in the treatment of airway inflammation [63].
Transcription (transcription) of IL-10 associated with corticosteroid, inflammation, antagonist and cinod
11) Confidence 0.17 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.32 Pain Relevance 0.89
, IL-9, IL-10, IL-13, IL-17A, and IL-17F transcripts were quantitated on single CD4+ T cells.
Transcription (transcripts) of IL-10 in T cells
12) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0
The concentration of PGE2, IL-10 and IL-18 was determined in culture medium of confluent cells incubated for their last 48 hours in Ham's F12/DMEM containing 1% ITS.
Transcription (concentration) of IL-10
13) Confidence 0.13 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0 Pain Relevance 0
Likewise, drastically reduced synthesis of IL-4 and IL-10 mRNA by synovial fluid mononuclear cells from RA patients correlates with disease activity [46].
Transcription (synthesis) of IL-10 in mononuclear cells associated with rheumatoid arthritis and disease
14) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.73 Pain Relevance 0.27
Higher levels of IL-4 and IL-10 mRNA within a joint are allied with a milder oligoarticular course and non-erosive disease67).
Transcription (levels) of IL-10 in joint
15) Confidence 0.11 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3012271 Disease Relevance 0.87 Pain Relevance 0.42
Outcome measures included T cell proliferation and IL-4, IL-5, and IL-13 secretion (assessed by [3H]-thymidine incorporation and ELISA, respectively) and characterization of the induced Treg by qRT-PCR for FoxP3, LAG3, CTLA4, and IL-10 mRNA expression.
Transcription (expression) of IL-10 in T cell
16) Confidence 0.04 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.36 Pain Relevance 0.14

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