INT60528

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Context Info
Confidence 0.42
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.86
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNFRSF1A) extracellular region (TNFRSF1A) plasma membrane (TNFRSF1A)
nucleus (TNFRSF1A) protein complex (TNFRSF1A)
TNFRSF1A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 7 100.00 Very High Very High Very High
Etanercept 6 99.92 Very High Very High Very High
rheumatoid arthritis 50 99.60 Very High Very High Very High
anesthesia 1 99.52 Very High Very High Very High
Inflammation 30 97.44 Very High Very High Very High
abdominal pain 2 94.16 High High
Pain 8 85.68 High High
cytokine 16 85.52 High High
Infliximab 12 85.00 Quite High
Adalimumab 75 78.48 Quite High
Disease Link Frequency Relevance Heat
Cancer 9 100.00 Very High Very High Very High
Necrosis 8 100.00 Very High Very High Very High
Rheumatoid Arthritis 51 99.60 Very High Very High Very High
Uveitis 52 97.84 Very High Very High Very High
INFLAMMATION 28 97.44 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 3 97.00 Very High Very High Very High
Erythema 1 94.72 High High
Immunodeficiency 2 94.52 High High
Abdominal Pain 2 94.16 High High
Syndrome 6 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucocorticosteroids and etanercept, a TNF-receptor antagonist, may be effective in the treatment of attacks.
Negative_regulation (antagonist) of TNF-receptor associated with antagonist and etanercept
1) Confidence 0.42 Published 2006 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 17194009 Disease Relevance 1.32 Pain Relevance 0.27
Increased levels of tumor necrosis factor-alpha messenger RNA were not associated with increased levels of IL-1 beta messenger RNA, suggesting differential regulation of these monokines in acquired immunodeficiency syndrome dementia.
Negative_regulation (levels) of tumor necrosis factor-alpha messenger RNA associated with necrosis, dementia, syndrome, cancer and immunodeficiency
2) Confidence 0.34 Published 1993 Journal Ann. Neurol. Section Abstract Doc Link 8498837 Disease Relevance 1.72 Pain Relevance 0.21
inhibition with a p55 TNF- receptor fusion protein (TNFr-Ig) lowered the intraocular inflammation.
Negative_regulation (inhibition) of p55 associated with inflammation
3) Confidence 0.26 Published 2010 Journal Middle East African Journal of Ophthalmology Section Body Doc Link PMC2991444 Disease Relevance 1.31 Pain Relevance 0.73
We also demonstrate for the first time receptor mediated driven disruption of TNFR1 binding to a number of associated proteins.
Negative_regulation (disruption) of TNFR1
4) Confidence 0.20 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.08 Pain Relevance 0
In a nutshell, the optimum combination of RI and EP on uric acid extraction was as follows:

Human studies

Negative_regulation (combination) of RI
5) Confidence 0.20 Published 2010 Journal Int J Nanomedicine Section Body Doc Link PMC3010161 Disease Relevance 0.18 Pain Relevance 0.12
Relative to the control subjects, patients with RA showed significant reductions of the mean values of F1Amp (-21%, p < 0.001, Fig. 4A), E1Amp (-37%, p < 0.001, Fig. 4A), RI (18%, p < 0.05, Fig. 4B) and ERI (-37%, p < 0.05; Fig. 4B).
Negative_regulation (reductions) of RI associated with rheumatoid arthritis
6) Confidence 0.02 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693559 Disease Relevance 0.24 Pain Relevance 0.12

General Comments

This test has worked.

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