INT6053

Context Info Confidence 0.72 First Reported 1991 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 107 Total Number 108 Disease Relevance 20.97 Pain Relevance 31.88

aging (Fos) nucleolus (Fos) nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)

Anatomy Link Frequency brain 10 nucleus 7 spinal cord 7 forebrain 5 spinal 4 Fos (Rattus norvegicus)

Pain Link Frequency Relevance Heat Pain 164 100.00 Enkephalin 65 100.00 Neuropeptide 37 100.00 electroacupuncture 25 100.00 Spinal cord 270 99.98 addiction 20 99.92 antagonist 246 99.84 Nerve growth factor 2 99.80 depression 201 99.76 fluoxetine 71 99.74

Disease Link Frequency Relevance Heat Cancer 6 100.00 Necrosis 2 100.00 Stress 1220 99.92 Depression 216 99.76 Nociception 90 99.28 Generalized Anxiety Disorder 198 99.20 Drug Induced Neurotoxicity 1 99.20 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 106 98.76 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 53 98.24 Cognitive Disorder 25 98.18

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both opiate and alpha2-adrenoceptor agonists reduced formalin-induced c-fos gene transcription and nocifensive behavior via their cognate receptors.

Transcription (transcription) of c-fos gene associated with agonist and opiate

1) Confidence 0.72 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10497900 Disease Relevance 0.08 Pain Relevance 0.86

RESULTS: Gastric acid challenge did not induce c-fos transcription in the spinal cord but caused many neurons in the nucleus tractus solitarii and area postrema to express c-fos messenger RNA (mRNA).

Transcription (transcription) of c-fos in nucleus

2) Confidence 0.69 Published 1998 Journal Gastroenterology Section Body Doc Link 9721162 Disease Relevance 0 Pain Relevance 0

It is hypothesized that the gastric acid-induced c-fos transcription in the brainstem is related to gastric chemonociception.

Transcription (transcription) of c-fos in brainstem

3) Confidence 0.69 Published 1998 Journal Gastroenterology Section Body Doc Link 9721162 Disease Relevance 0 Pain Relevance 0

Fluoxetine induces the transcription of genes encoding c-fos, corticotropin-releasing factor and its type 1 receptor in rat brain.

Transcription (transcription) of c-fos in brain associated with fluoxetine

4) Confidence 0.69 Published 1998 Journal Neuroscience Section Title Doc Link 9740405 Disease Relevance 0.09 Pain Relevance 0.60

ODC inactivation is associated with decreased transcription of the growth-related c-myc and c-fos genes.

Transcription (transcription) of c-fos

5) Confidence 0.69 Published 2007 Journal Biochem. Soc. Trans. Section Abstract Doc Link 17371277 Disease Relevance 0.46 Pain Relevance 0

It should be noted that the level of c-fos transcription was very low, as typically less than 0.7 c-fos mRNA-positive cells per lamina were counted in the 0.01 mm sections of the unilateral dorsal spinal cord (Figure 2).

Transcription (transcription) of c-fos in spinal cord associated with spinal cord

6) Confidence 0.69 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0 Pain Relevance 0.55

This effect was, however, not generalized throughout the brain as PGE2 inhibition failed to abolish IL-1beta-induced c-fos transcription in the nucleus of the solitary tract, parabrachial nucleus, bed nucleus of the stria terminalis, and the circumventricular organs.

Transcription (transcription) of c-fos in nucleus associated with parabrachial

7) Confidence 0.69 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10800959 Disease Relevance 0 Pain Relevance 0.36

However, c-fos transcription in the insular cortex was not enhanced by the gastric acid insult.

Transcription (transcription) of c-fos in insular cortex

8) Confidence 0.69 Published 2001 Journal Pain Section Abstract Doc Link 11323123 Disease Relevance 0.07 Pain Relevance 0.23

The low level of c-fos transcription in the laminae of the dorsal spinal cord made it compulsory to run the experiments involving HCl and capsaicin strictly in parallel with those involving the respective control/vehicle solution.

Transcription (transcription) of c-fos in spinal cord associated with qutenza and spinal cord

9) Confidence 0.69 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0.07 Pain Relevance 0.57

The sciatic nerve and the lumbar tract of the spinal cord were processed to evaluate the levels of the phosphorylated form of PKCgamma, ERK 1,2, SAP/JNK, p-38 and c-Jun; furthermore, the mRNA expression of the early genes c-Jun and c-Fos has been investigated.

Transcription (expression) of c-Fos in spinal cord associated with sciatic nerve and spinal cord

10) Confidence 0.69 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.57 Pain Relevance 0.57

Additionally, repeated administrations of nicotine transiently induced the c-fos and c-jun mRNA levels after the first-third nicotine administration, and the c-fos and c-jun mRNA levels were returned to the basal level after the seventh administration of nicotine. c-Fos, c-Jun and Fra-2 protein levels were persistently increased until the seventh administration.

Transcription (levels) of c-fos associated with nicotine

11) Confidence 0.69 Published 2002 Journal Life Sci. Section Abstract Doc Link 12269402 Disease Relevance 0 Pain Relevance 0.48

In this setting,NO2-Arg-Trim but not trimebutine, significantly down-regulated the spinal cFOS mRNA expression and increased blood concentrations of NO2 +NO3.

Transcription (expression) of cFOS in spinal

12) Confidence 0.69 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 19416632 Disease Relevance 1.15 Pain Relevance 1.09

c-fos and CRF receptor gene transcription in the brain of acetic acid-induced somato-visceral pain in rats.

Transcription (transcription) of c-fos in brain associated with pain and visceral pain

13) Confidence 0.69 Published 2004 Journal Pain Section Title Doc Link 15288415 Disease Relevance 0.07 Pain Relevance 0.59

In addition, PMA caused the induction of c-fos, c-jun and fra-1 mRNA level and, especially, PMA-induced increase of fra-1 mRNA level was further enhanced by CHX treatment at 4 h.

Transcription (level) of c-fos

14) Confidence 0.69 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9555062 Disease Relevance 0 Pain Relevance 0

Using the techniques of immunohistochemistry, Northern blotting and in situ hybridization, we have found that electroacupuncture (2/15Hz) accelerated the expression of mRNA and protein synthesis of immediate early genes c-fos, c-jun as well as proenkephalin gene in rat central nervous system (CNS).

Transcription (synthesis) of c-fos in CNS associated with central nervous system and electroacupuncture

15) Confidence 0.69 Published 1995 Journal Sheng Li Ke Xue Jin Zhan Section Abstract Doc Link 8584889 Disease Relevance 0 Pain Relevance 0.26

To further probe the dose-dependence of c-Fos and Egr-1 transcription on propofol concentration, we exposed the hippocampal slices to increasing concentrations of propofol for 60 min.

Transcription (transcription) of c-Fos associated with addiction

16) Confidence 0.69 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.05

Surprisingly, both lower and higher doses of propofol resulted in a non-significant, but sub-maximal induction of c-Fos transcription 24% ± 9% (P = 0.073, N = 3) and 43% ± 7% (P = 0.065, N = 3) increase for 5.6 ?

Transcription (transcription) of c-Fos

17) Confidence 0.69 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0

The transcription of c-Fos and Egr-1 genes was measured at several time intervals post treatment.

Transcription (transcription) of c-Fos

18) Confidence 0.69 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0

M propofol resulted in a significantly lower c-Fos (49% ± 12%; P = 0.024, N = 3) and higher Egr-1 (39% ± 7%; P = 0.046, N = 3) gene transcription compared to propofol treatment alone.

Transcription (transcription) of c-Fos

19) Confidence 0.67 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0

M) propofol caused a 80% induction in c-Fos transcription, and a 91% decrease in the transcription of Egr-1.

Transcription (transcription) of c-Fos

20) Confidence 0.67 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.04

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