INT60536

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Context Info
Confidence 0.22
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.12
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Gnrh1, Prl) extracellular space (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
pituitary 4
follicle 2
pars distalis 2
Gnrh1 (Rattus norvegicus)
Prl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 3 99.64 Very High Very High Very High
Dopamine 42 99.40 Very High Very High Very High
antagonist 120 99.16 Very High Very High Very High
narcan 2 98.74 Very High Very High Very High
Nerve growth factor 84 5.00 Very Low Very Low Very Low
Inflammation 81 5.00 Very Low Very Low Very Low
cytokine 66 5.00 Very Low Very Low Very Low
agonist 66 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 51 5.00 Very Low Very Low Very Low
substance P 48 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reprotox - General 1 5 99.20 Very High Very High Very High
Polycystic Ovary Syndrome 3 96.40 Very High Very High Very High
Eating Disorder 12 90.44 High High
Klinefelter Syndrome 3 59.00 Quite High
Endometriosis (extended) 3 38.28 Quite Low
Galactorrhea 6 9.80 Low Low
Stress 144 5.00 Very Low Very Low Very Low
INFLAMMATION 84 5.00 Very Low Very Low Very Low
Cancer 66 5.00 Very Low Very Low Very Low
Targeted Disruption 66 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also in teleost fish, GnRH stimulates PRL release in culture and this must be a direct effect on PRL cells since the rostral pars distalis is a nearly homogeneous population of PRL cells without gonadotrophs (151).
GnRH Positive_regulation (stimulates) of Localization (release) of PRL in pars distalis
1) Confidence 0.22 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.24 Pain Relevance 0
In human pituitary cell cultures, GnRH stimulated PRL secretion in an oestrogen-free environment and was inhibited by pretreating the cells with oestradiol (148).
GnRH Positive_regulation (stimulated) of Localization (secretion) of PRL in pituitary
2) Confidence 0.15 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.43 Pain Relevance 0
Furthermore, it should be noticed that GnRH has been reported to stimulate PRL release from a clonal cell line derived from embryonic pituitary cells (150).
GnRH Positive_regulation (stimulate) of Localization (release) of PRL in pituitary
3) Confidence 0.15 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.26 Pain Relevance 0
Effect of antagonists of dopamine and opiates on the basal and GnRH-induced secretion of luteinizing hormone, follicle stimulating hormone and prolactin during lactational amenorrhoea in breastfeeding women.
GnRH Positive_regulation (induced) of Localization (secretion) of prolactin in follicle associated with dopamine, antagonist, narcan, opiate and reprotox - general 1
4) Confidence 0.01 Published 1993 Journal Hum. Reprod. Section Title Doc Link 8501180 Disease Relevance 0.19 Pain Relevance 0.60

General Comments

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