INT6054

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Context Info
Confidence 0.70
First Reported 1990
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 67
Total Number 69
Disease Relevance 18.45
Pain Relevance 25.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
neuronal 10
dorsal 8
hippocampus 6
neurons 6
spinal cord 5
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 114 100.00 Very High Very High Very High
anesthesia 34 100.00 Very High Very High Very High
medulla 22 100.00 Very High Very High Very High
antidepressant 20 100.00 Very High Very High Very High
cocaine 18 100.00 Very High Very High Very High
cINOD 45 99.98 Very High Very High Very High
tricyclic antidepressant 5 99.76 Very High Very High Very High
Hyperalgesia 28 99.72 Very High Very High Very High
Sciatic nerve 14 99.68 Very High Very High Very High
Serotonin 45 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 507 100.00 Very High Very High Very High
INFLAMMATION 118 100.00 Very High Very High Very High
Shock 131 99.98 Very High Very High Very High
Cognitive Disorder 106 99.98 Very High Very High Very High
Death 81 99.98 Very High Very High Very High
Nociception 44 99.98 Very High Very High Very High
Convulsion 12 99.98 Very High Very High Very High
Cancer 19 99.84 Very High Very High Very High
Hyperalgesia 44 99.72 Very High Very High Very High
Depression 22 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electrical stimulation of sciatic nerve A- and C-fibers, but not of A alpha- and A beta-fibers alone, induced transient expression of KROX-24 in numerous spinal neurons in the termination area of the stimulated nerve.
Positive_regulation (induced) of Gene_expression (expression) of KROX-24 in nerve associated with c fibre and sciatic nerve
1) Confidence 0.70 Published 1990 Journal Neurosci. Lett. Section Abstract Doc Link 2293086 Disease Relevance 0.09 Pain Relevance 0.65
The serotonergic system modulates the cocaine-induced expression of the immediate early genes egr-1 and c-fos in rat brain.
Positive_regulation (induced) of Gene_expression (expression) of egr-1 in brain associated with cocaine
2) Confidence 0.70 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 9668660 Disease Relevance 0 Pain Relevance 0.38
Most notably, our results and those of others demonstrate that seizures increase the expression of messenger RNAs from immediate-early genes (c-fos, c-jun, and NGFI-A) which encode proteins that may mediate neuropeptide gene regulation.
Positive_regulation (increase) of Gene_expression (expression) of NGFI-A associated with convulsion and neuropeptide
3) Confidence 0.67 Published 1990 Journal Prog. Brain Res. Section Abstract Doc Link 2203104 Disease Relevance 0.69 Pain Relevance 0.50
Specifically, following context pre-exposure, immediate shock upregulated the expression of Zif268 protein in the dorsal hippocampus, the antisense oligodeoxynucleotide-mediated knockdown of which prevented subsequent contextual freezing.
Positive_regulation (upregulated) of Gene_expression (expression) of Zif268 protein in hippocampus associated with shock and hippocampus
4) Confidence 0.67 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2991235 Disease Relevance 0.65 Pain Relevance 0.10
Increased Egr1 and c-fos expression supports that deltamethrin and permethrin increased neuronal excitation in the present study.
Positive_regulation (Increased) of Gene_expression (expression) of Egr1 in neuronal
5) Confidence 0.65 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.08 Pain Relevance 0.11
For permethrin, expression of c-fos and Egr1 increases at 3 h, remains persistently elevated at 6 h and returns to control levels by 9 h.
Positive_regulation (increases) of Gene_expression (expression) of Egr1
6) Confidence 0.65 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0.03
In contrast, a stable LTF of C-fiber responses was obtained at 30 and 100 Hz CS, and at these frequencies there was a sharp increase in zif268 expression and appearance of Arc-positive neurons.
Positive_regulation (increase) of Gene_expression (expression) of zif268 in neurons associated with c fibre and aids-related complex
7) Confidence 0.65 Published 2008 Journal Neuroscience Section Abstract Doc Link 18555615 Disease Relevance 0.48 Pain Relevance 0.65
METH administration caused increases in the expression of c-fos, Egr1, and Nor-1 on the intact side.
Positive_regulation (caused) of Gene_expression (expression) of Egr1
8) Confidence 0.65 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3001483 Disease Relevance 0.05 Pain Relevance 0.52
show that object recognition induces Zif268 expression in both blades
Positive_regulation (induces) of Gene_expression (expression) of Zif268 associated with cognitive disorder
9) Confidence 0.59 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.29 Pain Relevance 0
extent, Narp. (2) Object exploration induces Zif268 expression across both
Positive_regulation (induces) of Gene_expression (expression) of Zif268
10) Confidence 0.59 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.85 Pain Relevance 0
However, the 2-min context re-exposure here upregulated dorsal hippocampal Zif268 expression, albeit to a significantly lesser extend than did the immediate shock.
Positive_regulation (upregulated) of Gene_expression (expression) of Zif268 in dorsal associated with shock
11) Confidence 0.58 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2991235 Disease Relevance 0.18 Pain Relevance 0.12
Significant increases in the expression of the early growth response genes Egr-1 and c-fos, but not c-jun, were found in the Ang II-infused left kidney compared to the control right kidney.
Positive_regulation (increases) of Gene_expression (expression) of Egr-1 in right kidney
12) Confidence 0.56 Published 1993 Journal Kidney Int. Section Abstract Doc Link 8455358 Disease Relevance 0 Pain Relevance 0.18
When these two stimuli were applied simultaneously a few c-Fos labelled cells did appear, and there was and an increased Krox-24 expression.
Positive_regulation (increased) of Gene_expression (expression) of Krox-24
13) Confidence 0.54 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0.06 Pain Relevance 0.53
Cocaine-induced egr-1 and c-fos expression was substantially reduced in the brain areas from rats in which the serotonergic projections were lesioned by injection of the neurotoxin 5,7-dihydroxytryptamine and in rats that have been injected with tropisetron, an antagonist of the 5-hydroxytryptamine (5-HT3) receptor.
Positive_regulation (Cocaine-induced) of Gene_expression (expression) of egr-1 in brain associated with antagonist and cocaine
14) Confidence 0.50 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668660 Disease Relevance 0 Pain Relevance 0.44
NGFI-A mRNA expression increased profoundly in the hippocampal formation and the cerebral cortex after all drug treatments, especially after moclobemide treatment (77-122% increase); with the exception of buspirone.
Positive_regulation (increased) of Gene_expression (expression) of NGFI-A in hippocampal formation associated with cerebral cortex
15) Confidence 0.49 Published 2000 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10958110 Disease Relevance 0 Pain Relevance 0.29
Moreover, after repeated methylphenidate treatment, cocaine-induced expression of c-fos and zif 268, as well as of substance P, was significantly attenuated throughout the striatum.
Positive_regulation (cocaine-induced) of Gene_expression (expression) of zif 268 in striatum associated with substance p and cocaine
16) Confidence 0.49 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511337 Disease Relevance 0 Pain Relevance 0.52
During the "central sensitization" phenomenon, noxious stimuli lead to expression of IEGs (c-fos, c-jun, krox-24); their proteic products have been postulated to convert short-term stimulations into long-lasting responses in dorsal-horn neurons.
Positive_regulation (lead) of Gene_expression (expression) of krox-24 in dorsal associated with central sensitization
17) Confidence 0.49 Published 1997 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 9403355 Disease Relevance 0 Pain Relevance 0.37
Expression of the immediate-early genes (IEG) c-FOS, NGF1-A and c-JUN was induced by noxious thermal stimulation in neurons of the rat spinal cord dorsal horn.
Positive_regulation (induced) of Gene_expression (Expression) of NGF1 in spinal cord dorsal horn associated with dorsal horn and spinal cord
18) Confidence 0.49 Published 1994 Journal Pain Section Abstract Doc Link 8159434 Disease Relevance 0 Pain Relevance 0.48
Acute methylphenidate treatment (0-10 mg/kg, i.p.) produced a dose-dependent increase in the expression of c-fos and zif 268.
Positive_regulation (increase) of Gene_expression (expression) of zif 268
19) Confidence 0.49 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511337 Disease Relevance 0 Pain Relevance 0.53
The alpha(2)-AR agonists, clonidine and UK14304 also had no effect on basal IEG levels, while blockade of alpha(2)-ARs by methoxyidazoxan significantly increased NGFI-A and c-fos expression, but decreased c-jun mRNA levels.
Positive_regulation (increased) of Gene_expression (expression) of NGFI-A associated with agonist and clonidine
20) Confidence 0.49 Published 2000 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11072104 Disease Relevance 0.65 Pain Relevance 0.68

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