INT60540

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Context Info
Confidence 0.35
First Reported 1993
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.94
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP26A1) endoplasmic reticulum (CYP26A1)
Anatomy Link Frequency
Islets of Langerhans 1
CYP26A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 6 97.60 Very High Very High Very High
fibrosis 6 40.96 Quite Low
agonist 6 8.68 Low Low
cytokine 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 48 98.68 Very High Very High Very High
Uterine Fibroids 240 98.24 Very High Very High Very High
Apoptosis 6 97.88 Very High Very High Very High
Pancreatitis 6 97.60 Very High Very High Very High
Pancreatic Cancer 6 96.16 Very High Very High Very High
Leukemia 4 83.00 Quite High
Cancer 18 54.88 Quite High
Pulmonary Fibrosis 4 41.76 Quite Low
Papillomavirus Infection 6 10.52 Low Low
Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant up-regulation of CYP26A1 in myometrial cells and down-regulation in leiomyoma cells resulted in approximate equal levels of CYP26A1 in these cells at 10?
Positive_regulation (up-regulation) of CYP26A1 associated with uterine fibroids
1) Confidence 0.35 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 0.82 Pain Relevance 0
RA regulates a number of genes involved in the RA pathway including the receptors and metabolizing enzymes such as CYP26.12–14 Up-regulation of CYP26A1 expression protects many cell types from apoptosis.15 We have previously demonstrated that CYP26 genes were up-regulated in leiomyomas as compared to myometrial tissue.6 Untreated leiomyoma cells (0 µm) demonstrated a 16·8 ± 4·5-fold up-regulation (P < 0·05) of CYP26A1 gene expression compared with myometrial cells (Table 1).
Positive_regulation (regulation) of CYP26 associated with uterine fibroids, rheumatoid arthritis and apoptosis
2) Confidence 0.35 Published 2008 Journal Clinical Endocrinology Section Body Doc Link PMC2610401 Disease Relevance 1.20 Pain Relevance 0
Islets of Langerhans showed high levels of P-450 IA2 in the donor group, with clear induction of P-450 IIIA1 and NADPH cytochrome P-450 oxidoreductase in patients with chronic pancreatitis but not in the pancreatic cancer group.
Neg (not) Spec (clear) Positive_regulation (induction) of P-450 IIIA1 in Islets of Langerhans associated with pancreatic cancer and chronic pancreatitis
3) Confidence 0.18 Published 1993 Journal J. Pathol. Section Abstract Doc Link 8501544 Disease Relevance 0.92 Pain Relevance 0.46

General Comments

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