INT60541

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Context Info
Confidence 0.61
First Reported 1993
Last Reported 2010
Negated 6
Speculated 2
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 6.76
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peroxisome (GSTK1) intracellular (GSTK1)
Anatomy Link Frequency
pancreas 1
brain 1
hippocampus 1
frontal cortex 1
kidney 1
GSTK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 8 100.00 Very High Very High Very High
Paracetamol 170 99.60 Very High Very High Very High
Hippocampus 22 99.52 Very High Very High Very High
Chronic pancreatitis 6 97.12 Very High Very High Very High
cINOD 8 94.00 High High
Neurotransmitter 1 92.48 High High
Inflammation 18 87.12 High High
Neurobehavioral 1 85.20 High High
ischemia 40 83.92 Quite High
anesthesia 4 80.20 Quite High
Disease Link Frequency Relevance Heat
Stress 98 99.40 Very High Very High Very High
Metastasis 1 98.92 Very High Very High Very High
Urological Neuroanatomy 25 98.88 Very High Very High Very High
Middle Cerebral Artery Infarction 56 98.48 Very High Very High Very High
Pancreatic Cancer 6 97.54 Very High Very High Very High
Cancer 39 97.20 Very High Very High Very High
Pancreatitis 6 97.12 Very High Very High Very High
Apoptosis 9 96.32 Very High Very High Very High
INFLAMMATION 21 93.44 High High
Epilepsy 2 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that sulindac itself increased QR activity as much as 2-fold over controls but had no effect on GST activity.
Neg (no) Regulation (effect) of GST
1) Confidence 0.61 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10660094 Disease Relevance 0.25 Pain Relevance 0.44
In this study we examined the effect of sulindac, sulindac sulfide, sulindac sulfone and aspirin on QR and GST activity.
Spec (examined) Regulation (effect) of GST associated with aspirin
2) Confidence 0.45 Published 1999 Journal Cancer Lett. Section Abstract Doc Link 10660094 Disease Relevance 0.26 Pain Relevance 0.44
In material from patients with chronic pancreatitis or pancreatic cancer, cytochrome P-450 enzyme levels were greater in both the liver and the pancreas than those seen in the donor group, while GST levels were unchanged.
Neg (unchanged) Regulation (unchanged) of GST in pancreas associated with pancreatic cancer and chronic pancreatitis
3) Confidence 0.38 Published 1993 Journal J. Pathol. Section Abstract Doc Link 8501544 Disease Relevance 0.94 Pain Relevance 0.47
Many other widely used drugs, including acetaminophen, clozapine, and furosemide, are metabolized to glutathione conjugates [36], although the reaction with glutathione is not necessarily dependent on GST catalysis in every case.
Neg (not) Regulation (dependent) of GST associated with paracetamol
4) Confidence 0.29 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.16 Pain Relevance 0.14
However, there have been a number of studies designed to address the effects of GST genotypes on survival and secondary malignancies after treatment for cancer, with several – although not all – studies finding an important role for GSTP1 polymorphisms in treatment outcomes.
Regulation (effects) of GST associated with cancer and metastasis
5) Confidence 0.22 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.50 Pain Relevance 0
In addition we observed no evidence of an up-regulation of HO-1 or GST in the bronchial tissues of subjects post wood smoke, which has previously been observed in cell models challenged with PM reflecting protective adaptation to the induction of oxidative stress [48].
Regulation (regulation) of GST associated with stress
6) Confidence 0.20 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2936868 Disease Relevance 0.25 Pain Relevance 0
Second, as discussed below, humans express a large number of different GSTs with overlapping substrate specificities, and the effects of polymorphisms (including gene deletions) affecting one GST may be masked by the activity of others.
Regulation (affecting) of GST
7) Confidence 0.17 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.18 Pain Relevance 0.08
On the other hand, kidney levels of total GST and GST-mu enzymatic activity were no different between the 4 inducer compound treated groups and the controls except for induction of GST-mu by curcumin (Figure 2B and Tables 3 and 4).
Neg (no) Regulation (different) of GST in kidney
8) Confidence 0.09 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1421427 Disease Relevance 0 Pain Relevance 0
As shown in Figures 5, 6, 7, a toxic dose of APAP exerted a lowering effect on the hepatic activities of GR, GST and GCS.
Regulation (effect) of GST associated with paracetamol
9) Confidence 0.08 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0 Pain Relevance 0.60
Large numbers of genes in the C. elegans genome encode detoxification enzymes such as cytochrome P450 (CYP), short-chain type dehydrogenase (SDR), UDP-glucuronosyl/glucosyl transferase (UGT), and glutathione S-transferase (GST) (WormBase, http://www.wormbase.org/), and they are probably regulated by conserved signal transduction pathways.
Spec (probably) Regulation (regulated) of GST
10) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2822842 Disease Relevance 0.96 Pain Relevance 0.04
Among all of the known gst genes (WormBase, http://www.wormbase.org/), gst-4, which encodes a sigma class GST, was one of the most up-regulated genes and most prominently expressed when the nematode was treated with the harmful food substance acrylamide [15].
Regulation (regulated) of GST
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2822842 Disease Relevance 0.40 Pain Relevance 0
Within a narrow range of potencies, HYTAU was somewhat more effective than NAC in curtailing the changes in GR and GST caused by APAP; and NAC was the only treatment compound to raise the GCS activity to baseline values.
Regulation (changes) of GST associated with paracetamol
12) Confidence 0.05 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0.07 Pain Relevance 0.52
Effects of oxidative stress were also confirmed based on alterations in antioxidant enzymes, GPx, GST and SOD in rat brain.
Regulation (alterations) of GST in brain associated with stress
13) Confidence 0.02 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 19460394 Disease Relevance 0.70 Pain Relevance 0.17
However, no significant changes in GSH, GPx, GR and GST levels of hippocampus and frontal cortex were observed in the rats treated only with the aqueous extract of Embelia ribes, as compared to the sham rats [Tables 3 and 4].


Neg (no) Regulation (changes) of GST in frontal cortex associated with urological neuroanatomy and hippocampus
14) Confidence 0.02 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792627 Disease Relevance 1.04 Pain Relevance 0.20
However, no significant changes in GSH, GPx, GR and GST levels of hippocampus and frontal cortex were observed in the rats treated only with the aqueous extract of Embelia ribes, as compared to the sham rats [Tables 3 and 4].


Neg (no) Regulation (changes) of GST in hippocampus associated with urological neuroanatomy and hippocampus
15) Confidence 0.01 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792627 Disease Relevance 1.04 Pain Relevance 0.20

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