INT6055

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 47
Total Number 49
Disease Relevance 3.61
Pain Relevance 7.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
brain 2
forebrain 2
PTN 2
nerve 2
hippocampal formation 1
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 5 100.00 Very High Very High Very High
addiction 25 99.72 Very High Very High Very High
depression 30 99.56 Very High Very High Very High
antidepressant 10 97.84 Very High Very High Very High
cerebral cortex 25 97.64 Very High Very High Very High
agonist 89 97.28 Very High Very High Very High
amygdala 75 97.08 Very High Very High Very High
Dopamine 232 96.88 Very High Very High Very High
antagonist 29 96.80 Very High Very High Very High
Enkephalin 27 94.92 High High
Disease Link Frequency Relevance Heat
Aids-related Complex 154 100.00 Very High Very High Very High
Depression 30 99.56 Very High Very High Very High
Hypertension 3 90.00 High High
Repression 8 88.12 High High
Amnesia 84 86.28 High High
Shock 10 84.60 Quite High
Osteogenic Sarcomas 8 84.60 Quite High
Death 3 79.76 Quite High
Frailty 1 79.16 Quite High
Apoptosis 24 75.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High basal levels of NGFI-A mRNA were present in cortical layers IV and VI, hippocampal CA1, piriform cortex, amygdala and caudate putamen. alpha 1-AR agonist and antagonist treatment had essentially no effect on IEG mRNA, despite producing characteristic behavioral and peripheral effects at the doses used.
Transcription (levels) of NGFI-A in caudate putamen associated with antagonist, agonist and amygdala
1) Confidence 0.69 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7723621 Disease Relevance 0 Pain Relevance 0.69
The transcription of c-Fos and Egr-1 genes was measured at several time intervals post treatment.
Transcription (transcription) of Egr-1
2) Confidence 0.68 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
To further probe the dose-dependence of c-Fos and Egr-1 transcription on propofol concentration, we exposed the hippocampal slices to increasing concentrations of propofol for 60 min.
Transcription (transcription) of Egr-1 associated with addiction
3) Confidence 0.68 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.05
Characterization of the time course of mRNA expression for Camk1g, Gpd1, c-fos and Egr1 demonstrates that altered expression of these transcripts also occurs at times earlier than 6 h following acute, oral pyrethroid exposure (Figure 4, Additional file 5).
Transcription (expression) of Egr1
4) Confidence 0.67 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.14 Pain Relevance 0.13
Dose-dependent changes in the transcription of several genes (Camk1g, Ddc, Gpd3, c-fos and Egr1) were discovered and successfully confirmed.
Transcription (transcription) of Egr1
5) Confidence 0.67 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.19 Pain Relevance 0.03
Biphasic changes in locomotor behavior and in expression of mRNA for NGFI-A and NGFI-B in rat striatum following acute caffeine administration.
Transcription (expression) of NGFI-A in striatum
6) Confidence 0.67 Published 1995 Journal J. Neurosci. Section Title Doc Link 7472512 Disease Relevance 0 Pain Relevance 0.22
The time course of expression of mRNA for NGFI-A and NGFI-B after a single intraperitoneal injection of saline or caffeine was examined using in situ hybridization.
Spec (examined) Transcription (expression) of NGFI-A
7) Confidence 0.67 Published 1995 Journal J. Neurosci. Section Abstract Doc Link 7472512 Disease Relevance 0 Pain Relevance 0
The effects of immobilization on the expression of immediate-early gene c-fos and nerve growth factor-inducible (NGFI)-B mRNAs, corticotropin-releasing factor (CRF) mRNA, CRF heteronuclear RNA (hnRNA), CRF receptor types 1 and 2alpha mRNA, and enkephalin hn/mRNA were investigated in the hypothalamic paraventricular nucleus of Wistar-Kyoto (WKY) rats and borderline hypertensive rats (BHRs).
Transcription (expression) of NGFI in nerve associated with nerve growth factor, hypertension and enkephalin
8) Confidence 0.67 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9523573 Disease Relevance 0.24 Pain Relevance 0.27
In contrast, propofol significantly reduced the transcription of Egr-1 in all concentrations including both lower concentration of 5.6 ?
Transcription (transcription) of Egr-1
9) Confidence 0.65 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.04
M) propofol caused a 80% induction in c-Fos transcription, and a 91% decrease in the transcription of Egr-1.
Transcription (transcription) of Egr-1
10) Confidence 0.65 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.04
M propofol resulted in a significantly lower c-Fos (49% ± 12%; P = 0.024, N = 3) and higher Egr-1 (39% ± 7%; P = 0.046, N = 3) gene transcription compared to propofol treatment alone.
Transcription (transcription) of Egr-1
11) Confidence 0.65 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
M propofol resulted in 91% ± 4% (P = 0.006, N = 3) decrease in Egr-1 transcription.
Transcription (transcription) of Egr-1
12) Confidence 0.65 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.03
Both lower and higher doses of propofol resulted in significant decrease of Egr-1 transcription, 87% ± 5% (P = 0.032, N = 3) and 94% ± 3% (P = 0.008, N = 3) decrease for 5.6 ?
Transcription (transcription) of Egr-1
13) Confidence 0.65 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.04
Pretreatment of hippocampal slices with RAS, RAF, MEK, ERK or p38-MAPK inhibitors for 60 min did not significantly change the transcription of c-Fos or Egr-1.
Transcription (transcription) of Egr-1
14) Confidence 0.65 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
M propofol resulted in 91% ± 4% fold (P = 0.006, N = 3) inhibition in Egr-1 transcription.
Transcription (transcription) of Egr-1
15) Confidence 0.65 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.04
Analysis of c-Fos and Egr-1 transcription was carried out using Mx3000P QPCR system (Stratagene, La Jolla, CA).
Transcription (transcription) of Egr-1
16) Confidence 0.65 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0
In contrast, propofol caused a time and concentration dependant down regulation of Egr-1 transcription and was completely inhibited at 60 min and remained inhibited for up to 240 min for all concentrations.
Transcription (transcription) of Egr-1
17) Confidence 0.65 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2916009 Disease Relevance 0 Pain Relevance 0.03
The immediate early transcription factors c-fos and Egr1 were upregulated by deltamethrin and permethrin.
Transcription (transcription) of Egr1
18) Confidence 0.65 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.09 Pain Relevance 0.12
minutes to reach maximum arc/zif-268 mRNA levels with reference to the moment when criterion was reached.
Transcription (levels) of zif-268 associated with aids-related complex
19) Confidence 0.64 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.19 Pain Relevance 0
minutes after reaching state criterion was the induction kinetics of arc and zif-268 mRNA, characterized by a bell-shaped profile that peaks 30?
Transcription (kinetics) of zif-268 associated with aids-related complex
20) Confidence 0.64 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.19 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox