INT60552

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Context Info
Confidence 0.79
First Reported 1993
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 56
Total Number 58
Disease Relevance 20.05
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNI3) cytoplasm (TNNI3)
Anatomy Link Frequency
coronary artery 3
mitral valve 3
eyes 1
blood 1
chest 1
TNNI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 65 100.00 Very High Very High Very High
anesthesia 43 97.56 Very High Very High Very High
ischemia 58 97.16 Very High Very High Very High
Inflammation 68 94.48 High High
depression 11 94.20 High High
Inflammatory response 42 92.24 High High
cytokine 24 74.96 Quite High
Calcium channel 2 55.32 Quite High
chemokine 9 44.56 Quite Low
fibrosis 37 44.00 Quite Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 29 100.00 Very High Very High Very High
Sepsis 145 99.68 Very High Very High Very High
Necrosis 167 99.24 Very High Very High Very High
Angina 47 99.24 Very High Very High Very High
Congenital Anomalies 38 98.96 Very High Very High Very High
Cognitive Disorder 72 98.72 Very High Very High Very High
Acute Coronary Syndrome 105 98.68 Very High Very High Very High
Emergencies 45 98.40 Very High Very High Very High
Injury 403 98.36 Very High Very High Very High
Coronary Artery Disease 120 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To date no data regarding coagulation disturbances as a possible mechanism for cTnI release during sepsis are available.


Localization (release) of cTnI associated with sepsis
1) Confidence 0.79 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2815772 Disease Relevance 1.13 Pain Relevance 0.05
However, the mechanisms underlying cTnI release in these patients are still unknown.
Localization (release) of cTnI
2) Confidence 0.79 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2815772 Disease Relevance 1.07 Pain Relevance 0.04
Fourth, our study provides some insights into the different mechanisms involved in 'basal' and pathological postoperative cTnI release in main types of adult cardiac surgery with CPB, but do not test appropriate strategies to improve outcome in identified high-risk patients.
Localization (release) of cTnI
3) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.07 Pain Relevance 0
We therefore decided to conduct a comparative study between CABG, valve surgery, and combined surgery in order to determine the postoperative cTnI release and the thresholds of cTnI that predict adverse outcome – the hypothesis tested being that both cTnI release and the thresholds would differ among procedure types.
Localization (release) of cTnI
4) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0 Pain Relevance 0
The definition of the threshold of postoperative cTnI release associated with a poor outcome may therefore be of paramount importance in cardiac surgery to identify a transition in postoperative risk.
Localization (release) of cTnI
5) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.28 Pain Relevance 0
Patients with increased risk of postoperative cardiac morbidity and mortality or of cTnI release (n = 475 patients, 17%) were excluded: emergency surgery in <24 hours (n = 86 patients, 3%), reoperative procedures (n = 58 patients, 2%), recent history (<4 weeks) of acute myocardial infarction and abnormal preoperative cTnI values >0.6 ng/ml (n = 101 patients, 4%), and various other surgical procedures (n = 230 patients, 8%) including valve repair and aortic valve plus mitral valve replacement.
Localization (release) of cTnI in mitral valve associated with emergencies and myocardial infarction
6) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.19 Pain Relevance 0
Moreover, whether the potential differences in cTnI release among procedure types may influence, first, the threshold of cTnI associated with an adverse postoperative outcome and, second, the accuracy of cTnI to predict such an adverse outcome remains unknown.
Localization (release) of cTnI
7) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.13 Pain Relevance 0
Since we previously found in elective CABG surgery that the overall amount of cardiac cells injured (whatever the mechanisms of myocardial tissue insult) was reflected by postoperative cTnI release and was well correlated with the short-term and long-term clinical outcome [12], it is probable that both an increase in basal postoperative cTnI release and the worst outcome are linked in combined surgery.
Localization (release) of cTnI
8) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.29 Pain Relevance 0
An elevated postoperative cTnI release was a strong and independent predictor of severe cardiac events and inhospital death after conventional cardiac surgery, whatever the type of surgery.
Localization (release) of cTnI associated with death
9) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.35 Pain Relevance 0
Whatever the various mechanisms that explain the postoperative cTnI release in cardiac surgery, it has been shown that cTnI is an independent predictor of short-term and long-term adverse outcome in cardiac surgical patients [11,12].
Localization (release) of cTnI
10) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.37 Pain Relevance 0
This result is not surprising since a higher 'basal' cTnI release may have masked some small releases of cTnI due to myocardial necrosis induced by causes other than direct surgical trauma and/or CPB.
Localization (releases) of cTnI associated with necrosis and injury
11) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.35 Pain Relevance 0
This result is not surprising since a higher 'basal' cTnI release may have masked some small releases of cTnI due to myocardial necrosis induced by causes other than direct surgical trauma and/or CPB.
Localization (release) of cTnI associated with necrosis and injury
12) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.34 Pain Relevance 0
Again, a probable explanation is that surgical trauma is less in CABG than that in valve surgery or combined surgery and that the duration of CPB plays a role in the postoperative release of cTnI in the absence of cardiac complications.
Localization (release) of cTnI associated with injury
13) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.24 Pain Relevance 0
Since we previously found in elective CABG surgery that the overall amount of cardiac cells injured (whatever the mechanisms of myocardial tissue insult) was reflected by postoperative cTnI release and was well correlated with the short-term and long-term clinical outcome [12], it is probable that both an increase in basal postoperative cTnI release and the worst outcome are linked in combined surgery.
Localization (release) of cTnI
14) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0.28 Pain Relevance 0
We therefore decided to conduct a comparative study between CABG, valve surgery, and combined surgery in order to determine the postoperative cTnI release and the thresholds of cTnI that predict adverse outcome – the hypothesis tested being that both cTnI release and the thresholds would differ among procedure types.
Spec (determine) Localization (release) of cTnI
15) Confidence 0.78 Published 2007 Journal Crit Care Section Body Doc Link PMC2556750 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Myocardial damage measured by cardiac troponin release was not reduced by volatile anesthetics in patients undergoing mitral valve surgery, whereas it was reduced in patients with concomitant coronary artery disease.


Localization (release) of cardiac troponin in mitral valve
16) Confidence 0.78 Published 2007 Journal J. Cardiothorac. Vasc. Anesth. Section Body Doc Link 17905272 Disease Relevance 0 Pain Relevance 0
These microinfarcts can often be accompanied by chest pain in the patients and diagnosed by the release of cardiac troponin into the serum [19].
Localization (release) of cardiac troponin in chest associated with angina
17) Confidence 0.78 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.89 Pain Relevance 0.17
Peak postoperative troponin I release was measured as a marker of myocardial necrosis.
Localization (release) of troponin I
18) Confidence 0.76 Published 2006 Journal J. Cardiothorac. Vasc. Anesth. Section Body Doc Link 16884976 Disease Relevance 0 Pain Relevance 0
Measurement of cardiac troponin can be useful as a non-invasive method to determine suspected myocardial injury, for example in cases presented with cardiac arrhythmia, severe depression or multi organ dysfunctions.
Localization (Measurement) of cardiac troponin associated with depression, injury and arrhythmia under development
19) Confidence 0.73 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.36 Pain Relevance 0.21
With use of HRTII-RCM, we were able to observe abnormalities of cell shape and cell density in the eyes affected by TSPK.
Localization (use) of RCM in eyes associated with congenital anomalies and corneal disease
20) Confidence 0.73 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2718741 Disease Relevance 0.50 Pain Relevance 0.03

General Comments

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