INT60556

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Context Info
Confidence 0.61
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.90
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Epc1) nucleus (Epc1)
Anatomy Link Frequency
endothelial cells 2
monocyte 1
EPC 1
Epc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 2 99.76 Very High Very High Very High
Neurotransmitter 1 99.56 Very High Very High Very High
Inflammation 87 87.68 High High
chemokine 3 87.40 High High
Inflammatory response 9 52.60 Quite High
fluoxetine 1 25.00 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Buprenorphine 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 349 99.46 Very High Very High Very High
Diabetes Mellitus 114 99.32 Very High Very High Very High
Adhesions 9 98.28 Very High Very High Very High
Apoptosis 27 97.76 Very High Very High Very High
INFLAMMATION 96 87.68 High High
Wound Healing 34 85.12 High High
Acute Liver Failure 22 77.76 Quite High
Repression 3 35.76 Quite Low
Cancer 3 21.04 Low Low
Pathologic Neovascularization 2 20.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The neurotransmitter serotonin (5-HT) was localized in the ectoplacental cone (EPC) and placenta of the day 9-12 (E9-12) mouse embryo in vivo and in whole embryo cultures, using immunocytochemistry with a specific 5-HT antiserum.
Localization (localized) of EPC in EPC associated with neurotransmitter and serotonin
1) Confidence 0.61 Published 1993 Journal Placenta Section Abstract Doc Link 8506248 Disease Relevance 0 Pain Relevance 0.14
Furthermore, it has been reported that the transplanted EPC secreted growth factor in a paracrine manner and inhibited cell apoptosis through R1 and R2.
Localization (secreted) of EPC associated with apoptosis
2) Confidence 0.09 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2933582 Disease Relevance 0.79 Pain Relevance 0
Although we did not detect any changes in Vegf expression, chemoattractant molecules monocyte chemoattractant protein-1 (MCP-1/Ccl2) and Defb15, both potent inducers of EPC mobilization and recruitment [33, 34], were independently confirmed by quantitative PCR (Fig. 6F).
Localization (mobilization) of EPC in monocyte
3) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.33 Pain Relevance 0.10
Although we did not detect any differences in VEGF expression itself, reduced VEGF signaling, as well as aberrant cell adhesion properties of EPCs to endothelial cells in diabetic wounds, also contributes to poor EPC recruitment and retention [45–47].
Localization (recruitment) of EPC in endothelial cells associated with diabetes mellitus, injury and adhesions
4) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 1.26 Pain Relevance 0.16
However, because HOXA3 has been previously shown to promote angiogenesis and endothelial cell migration, we chose to focus on factors from this gene set that directly promote EPC mobilization and EPC/endothelial cell migration (Fig. 6E).
Localization (mobilization) of EPC in endothelial cell
5) Confidence 0.07 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.52 Pain Relevance 0.09

General Comments

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