INT6056

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2010
Negated 23
Speculated 13
Reported most in Abstract
Documents 601
Total Number 614
Disease Relevance 193.05
Pain Relevance 386.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 150
spinal 110
dorsal horn 69
neurons 61
brain 50
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 1181 100.00 Very High Very High Very High
Spinal cord 947 100.00 Very High Very High Very High
Morphine 812 100.00 Very High Very High Very High
Acupuncture 604 100.00 Very High Very High Very High
Dopamine 563 100.00 Very High Very High Very High
Inflammation 559 100.00 Very High Very High Very High
Dorsal horn 459 100.00 Very High Very High Very High
Spinal nerve ligature 400 100.00 Very High Very High Very High
withdrawal 389 100.00 Very High Very High Very High
allodynia 363 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 1044 100.00 Very High Very High Very High
Nociception 787 100.00 Very High Very High Very High
Neuropathic Pain 622 100.00 Very High Very High Very High
INFLAMMATION 500 100.00 Very High Very High Very High
Stress 386 100.00 Very High Very High Very High
Hyperalgesia 343 100.00 Very High Very High Very High
Urological Neuroanatomy 233 100.00 Very High Very High Very High
Injury 225 100.00 Very High Very High Very High
Pressure And Volume Under Development 194 100.00 Very High Very High Very High
Depression 184 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nor-trimebutine decreased Fos expression in the thoraco-lumbar (peritoneal irritation) and lumbo-sacral (colonic inflammation) spinal cord in laminae I, IIo V, VII and X.
Negative_regulation (decreased) of Gene_expression (expression) of Fos in spinal cord associated with inflammation and spinal cord
1) Confidence 0.59 Published 2005 Journal Life Sci. Section Abstract Doc Link 15978629 Disease Relevance 0.68 Pain Relevance 0.67
In laminae I-II of the L4-L5 segment, the magnitude of the decrease in Fos expression was comparable for remifentanil (26.5%) and lidocaine (27.3%); the decrease was greater when both remifentanil and lidocaine were administered (50.5%), and even greater when bupivicaine and lidocaine were used (74.2%).
Negative_regulation (decrease) of Gene_expression (expression) of Fos associated with ultiva and lidocaine
2) Confidence 0.59 Published 1997 Journal Pain Section Abstract Doc Link 9060019 Disease Relevance 0.39 Pain Relevance 1.92
The treatments dose dependently decreased both Fos immunoreactivity expression in dorsal horn of rat lumbar spinal cord and all nociceptive measures in the tonic phase of the formalin test. c-Fos correlated well with weighted pain score and/or flinching responses, but not with licking/biting behavior.
Negative_regulation (decreased) of Gene_expression (expression) of Fos in dorsal horn associated with nociception, pain score, dorsal horn and spinal cord
3) Confidence 0.59 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9218679 Disease Relevance 0.51 Pain Relevance 0.31
On the other hand, the finding that the intrathecal injection of lidocaine after formalin treatment reduced Fos expression but not nociceptive responses indicates an uncoupling of the behavioral and Fos protein responses to formalin and suggests that changes in Fos expression may not be a good predictor of the ability of agents to produce preemptive analgesia.


Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of Fos
4) Confidence 0.59 Published 1998 Journal Anesthesiology Section Body Doc Link 9447868 Disease Relevance 0.05 Pain Relevance 0
In the saline group, Fos expression was detected predominantly in laminae I-II and V-VI, and the total Fos expression was maximal at 1 h and then decreased gradually.
Negative_regulation (decreased) of Gene_expression (expression) of Fos
5) Confidence 0.59 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041605 Disease Relevance 0.13 Pain Relevance 1.27
IMPLICATIONS: Prevention of early pain by pretreatment with local anesthetics provides little benefit for postoperative pain relief in the plantar incision model, although c-Fos expression is suppressed.
Negative_regulation (suppressed) of Gene_expression (expression) of Fos associated with pain, perioperative pain and local anesthetic
6) Confidence 0.59 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041605 Disease Relevance 0.20 Pain Relevance 0.99
Pretreatment with local anesthetics suppressed Fos expression significantly in all layers, and this suppression continued for several days.
Negative_regulation (suppressed) of Gene_expression (expression) of Fos associated with local anesthetic
7) Confidence 0.59 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15041605 Disease Relevance 0.14 Pain Relevance 1.27
Lidocaine blockade of amygdala output in fear-conditioned rats reduces Fos expression in the ventrolateral periaqueductal gray.
Negative_regulation (reduces) of Gene_expression (expression) of Fos in amygdala associated with anxiety disorder, central grey, amygdala and lidocaine
8) Confidence 0.59 Published 2000 Journal Neuroscience Section Title Doc Link 10682714 Disease Relevance 0.73 Pain Relevance 0.68
Finally, although freezing was only partly reduced in the conditioned animals unilaterally injected with lidocaine, it was significantly correlated to the ipsilateral reduction in Fos expression.
Negative_regulation (reduction) of Gene_expression (expression) of Fos associated with lidocaine
9) Confidence 0.59 Published 2000 Journal Neuroscience Section Abstract Doc Link 10682714 Disease Relevance 0.52 Pain Relevance 0.87
Capsaicin- or formalin-induced Fos expression was reduced in both cases by pretreatment of capsazepine, but to a much lesser extent for formalin.
Negative_regulation (reduced) of Gene_expression (expression) of Fos associated with qutenza
10) Confidence 0.59 Published 1998 Journal Neuroscience Section Abstract Doc Link 9881874 Disease Relevance 0.80 Pain Relevance 1.32
The results show that, when lidocaine was microinjected in the medial part of the central nucleus of the amygdala or along the ventral amygdalofugal pathway of conditioned rats, fear-induced Fos expression in the ventrolateral periaqueductal gray was reduced on the side ipsilateral to the injection (up to 37% reduction in comparison to the contralateral side).
Negative_regulation (reduced) of Gene_expression (expression) of Fos in nucleus associated with anxiety disorder, central grey, amygdala and lidocaine
11) Confidence 0.59 Published 2000 Journal Neuroscience Section Abstract Doc Link 10682714 Disease Relevance 0.77 Pain Relevance 0.91
Fedotozine, a kappa-opioid agonist, prevents spinal and supra-spinal Fos expression induced by a noxious visceral stimulus in the rat.
Negative_regulation (prevents) of Gene_expression (expression) of Fos in spinal associated with mu agonist and qutenza
12) Confidence 0.59 Published 2000 Journal Neurogastroenterol. Motil. Section Title Doc Link 10771495 Disease Relevance 0.16 Pain Relevance 0.83
In addition, BV treatment significantly suppressed adjuvant-induced Fos expression in the lumbar spinal cord at 3 weeks post-adjuvant injection.
Negative_regulation (suppressed) of Gene_expression (expression) of Fos in spinal cord associated with spinal cord
13) Confidence 0.59 Published 2001 Journal Pain Section Abstract Doc Link 11207399 Disease Relevance 2.05 Pain Relevance 0.99
Local anesthetic pretreatment was effective in reducing Fos expression only for the long acting bupivacaine; lidocaine without and with epinephrine (1:100,000) failed to significantly affect Fos expression.
Negative_regulation (reducing) of Gene_expression (expression) of Fos associated with lidocaine and local anesthetic
14) Confidence 0.59 Published 2005 Journal J Endod Section Abstract Doc Link 16044040 Disease Relevance 0.29 Pain Relevance 1.12
Pretreatment with morphine 30 min before pulp exposure dose-dependently (2.5, 5, and 10 mg/kg subcutaneously) reduced Fos expression in subnucleus caudalis whereas pretreatment with ibuprofen (10-100 mg/kg subcutaneously) did not significantly affect Fos expression.
Negative_regulation (reduced) of Gene_expression (expression) of Fos associated with morphine
15) Confidence 0.59 Published 2005 Journal J Endod Section Abstract Doc Link 16044040 Disease Relevance 0.28 Pain Relevance 0.88
The increased Fos expression is blocked by N(G)-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, but not by its inactive isomer N(G)-nitro-D-arginine methyl ester.
Negative_regulation (blocked) of Gene_expression (expression) of Fos
16) Confidence 0.59 Published 2000 Journal Neuroscience Section Abstract Doc Link 10683575 Disease Relevance 0 Pain Relevance 0.34
Aspirin and acetaminophen reduced both Fos expression in rat lumbar spinal cord and inflammatory signs produced by carrageenin inflammation.
Negative_regulation (reduced) of Gene_expression (expression) of Fos in spinal cord associated with aspirin, paracetamol, inflammation and spinal cord
17) Confidence 0.59 Published 1995 Journal Pain Section Title Doc Link 8719538 Disease Relevance 0.36 Pain Relevance 1.15
Fos expression in the spinal cord is suppressed in rats displaying conditioned hypoalgesia.
Negative_regulation (suppressed) of Gene_expression (expression) of Fos in spinal cord associated with nociceptor, hypoalgesia and spinal cord
18) Confidence 0.59 Published 1995 Journal Behav. Neurosci. Section Title Doc Link 7619322 Disease Relevance 0.19 Pain Relevance 0.45
Both drugs inhibited D-fenfluramine-induced Fos expression in the cingulate cortex, frontal cortex, and the parvocellular subdivision of the paraventricular nucleus of the hypothalamus.
Negative_regulation (inhibited) of Gene_expression (expression) of Fos in nucleus associated with urological neuroanatomy
19) Confidence 0.59 Published 1997 Journal Brain Res. Section Abstract Doc Link 9452197 Disease Relevance 0.25 Pain Relevance 0.58
p-Chlorophenylalanine and fluoxetine inhibit D-fenfluramine-induced Fos expression in the paraventricular nucleus, cingulate cortex and frontal cortex but not in other forebrain and brainstem regions.
Negative_regulation (inhibit) of Gene_expression (expression) of Fos in nucleus associated with medulla, urological neuroanatomy and fluoxetine
20) Confidence 0.59 Published 1997 Journal Brain Res. Section Title Doc Link 9452197 Disease Relevance 0.26 Pain Relevance 0.51

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