INT60568

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Context Info
Confidence 0.38
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 3.60
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Mtx1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methotrexate 278 100.00 Very High Very High Very High
fibrosis 22 98.52 Very High Very High Very High
Inflammation 184 79.12 Quite High
cytokine 95 78.08 Quite High
sodium channel 1 75.60 Quite High
chemokine 3 75.20 Quite High
tetrodotoxin 1 72.84 Quite High
Inflammatory mediators 13 66.80 Quite High
anesthesia 7 63.60 Quite High
cINOD 1 56.72 Quite High
Disease Link Frequency Relevance Heat
Acute Myocarditis 60 100.00 Very High Very High Very High
Enteritis 51 99.48 Very High Very High Very High
Cardiovascular Disorder Under Development 14 98.52 Very High Very High Very High
Urological Neuroanatomy 24 94.88 High High
Diarrhoea 6 92.44 High High
Dilated Cardiomyopathy 14 89.76 High High
INFLAMMATION 200 79.12 Quite High
Fibrosis 10 77.48 Quite High
Ventricular Remodeling 12 76.12 Quite High
Glioma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observation that the effects of MTX were inhibited by structural mimics of both its hydrophobic and hydrophilic portions implies that both portions of the MTX molecule recognize its target.
Negative_regulation (inhibited) of MTX
1) Confidence 0.38 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9422388 Disease Relevance 0.13 Pain Relevance 0.11
Interaction studies indicated that there was secretory inhibition of MTX as evidenced by a decrease in both excretion ratio and tubular clearance at 25 micrograms/ml of MTX.
Negative_regulation (inhibition) of MTX associated with methotrexate
2) Confidence 0.35 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8509997 Disease Relevance 0.06 Pain Relevance 0.61
Data showed that curcumin reduced the levels of D-lactate and DAO in MTX-induced rat enteritis model (Fig. 2).
Negative_regulation (reduced) of MTX associated with enteritis and methotrexate
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.81 Pain Relevance 0.37
0.000), but in MTX+curcumin group and MTX+NAC group, it was markedly decreased (p?
Negative_regulation (decreased) of MTX+NAC associated with methotrexate
4) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.87 Pain Relevance 0.62
Rats were randomly divided into 4 groups: control group (peritoneal injection of normal saline only), MTX group (MTX, 20 mg/kg), MTX+curcumin group (MTX, 20 mg/kg; curcumin, 100 mg/kg) and MTX+NAC positive control group (MTX, 20 mg/kg; NAC, 150 mg/kg).
Negative_regulation (group) of MTX+NAC associated with methotrexate
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945766 Disease Relevance 0.34 Pain Relevance 0.55
However, in the EAM-MTX group, the green staining of the collagen fibers was markedly reduced, compared with that in the EAM60 group (Figures 3(b) and 3(c)).
Negative_regulation (reduced) of EAM-MTX associated with methotrexate and acute myocarditis
6) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768010 Disease Relevance 0.85 Pain Relevance 0.38
However, the size of the discolored area was significantly reduced in the EAM-MTX group.
Negative_regulation (reduced) of EAM-MTX associated with methotrexate and acute myocarditis
7) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768010 Disease Relevance 0.55 Pain Relevance 0.23

General Comments

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