INT6057

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 19
Disease Relevance 4.17
Pain Relevance 7.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Egr1) intracellular (Egr1) DNA binding (Egr1)
transcription factor binding (Egr1) cytoplasm (Egr1)
Anatomy Link Frequency
striatum 4
nerve 2
brain 2
cortex 2
spinal cord 1
Egr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 23 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
cocaine 222 99.82 Very High Very High Very High
Spinal cord 5 99.76 Very High Very High Very High
Serotonin 8 99.72 Very High Very High Very High
Morphine 7 98.24 Very High Very High Very High
Hippocampus 132 97.68 Very High Very High Very High
fluoxetine 3 97.56 Very High Very High Very High
bradykinin 1 96.80 Very High Very High Very High
drug abuse 2 96.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 130 100.00 Very High Very High Very High
INFLAMMATION 22 100.00 Very High Very High Very High
Shock 80 99.50 Very High Very High Very High
Death 6 97.08 Very High Very High Very High
Drug Dependence 5 96.32 Very High Very High Very High
Nociception 5 94.48 High High
Anxiety Disorder 66 92.52 High High
Pain 16 89.24 High High
Pheochromocytoma 1 88.96 High High
Disease 7 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The suppressive effects of pentobarbital were not specific to c-Fos, such that pentobarbital also suppressed expression of ITFs FosB and Egr1 in the striatum of cocaine-treated rats.
Negative_regulation (suppressed) of Gene_expression (expression) of Egr1 in striatum associated with cocaine
1) Confidence 0.57 Published 2000 Journal Brain Res. Section Abstract Doc Link 10986339 Disease Relevance 0.06 Pain Relevance 0.68
In contrast, FosB was induced and continued to rise in all areas, whereas the basal expressions of c-Jun and Krox-24 were initially reduced but then returned during the subsequent 36 h.
Negative_regulation (reduced) of Gene_expression (expressions) of Krox-24
2) Confidence 0.45 Published 2001 Journal Brain Res. Section Abstract Doc Link 11251193 Disease Relevance 0.08 Pain Relevance 0.43
Cocaine-induced egr-1 and c-fos expression was substantially reduced in the brain areas from rats in which the serotonergic projections were lesioned by injection of the neurotoxin 5,7-dihydroxytryptamine and in rats that have been injected with tropisetron, an antagonist of the 5-hydroxytryptamine (5-HT3) receptor.
Negative_regulation (reduced) of Gene_expression (expression) of egr-1 in brain associated with antagonist and cocaine
3) Confidence 0.43 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9668660 Disease Relevance 0 Pain Relevance 0.44
In conclusion the localization of the expression of c-fos and NGFI-A mRNAs represents a useful neuroanatomical technique for detecting the cell bodies of neurones that are activated by cardiovascular nerve afferents and should allow the further characterization of the neurochemical identity of these neurones.
Negative_regulation (localization) of Gene_expression (expression) of NGFI-A in nerve
4) Confidence 0.41 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1320720 Disease Relevance 0 Pain Relevance 0.11
Moreover, after repeated methylphenidate treatment, cocaine-induced expression of c-fos and zif 268, as well as of substance P, was significantly attenuated throughout the striatum.
Negative_regulation (attenuated) of Gene_expression (expression) of zif 268 in striatum associated with substance p and cocaine
5) Confidence 0.41 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14511337 Disease Relevance 0 Pain Relevance 0.52
The Zif268 ASO-infused rats remained significantly impaired relative to MSO-infused controls across both tests (Treatment?
Negative_regulation (impaired) of Gene_expression (rats) of Zif268 ASO-infused
6) Confidence 0.41 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2991235 Disease Relevance 0.38 Pain Relevance 0.03
Experience-dependent IEG reinduction during REM sleep is at variance with studies showing that sleep downregulates the expression of IEGs such as zif-268 and c-fos (Basheer et al., 1997; Cirelli and Tononi, 1998, 2000a; O'Hara et al., 1993; Pompeiano et al., 1992, 1994).
Negative_regulation (downregulates) of Gene_expression (expression) of zif-268
7) Confidence 0.39 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0 Pain Relevance 0
recently reported coordinate expression of BDNF, Zif268, PSD-95, and pCaMKII in
Negative_regulation (coordinate) of Gene_expression (expression) of Zif268
8) Confidence 0.36 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.22 Pain Relevance 0.09
min prior to context pre-exposure or to the immediate shock session (apart from the delayed Zif268 group, for which the infusions were delayed until 4?
Negative_regulation (delayed) of Gene_expression (group) of Zif268 associated with shock
9) Confidence 0.36 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2991235 Disease Relevance 0.55 Pain Relevance 0.03
The reductions of Zif/268 expression by endomorphins were greater than those by morphine, while the reductions of c-Fos expression by endomorphins were smaller than those by morphine.
Negative_regulation (reductions) of Gene_expression (expression) of Zif/268 associated with morphine
10) Confidence 0.35 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12223232 Disease Relevance 0.07 Pain Relevance 0.60
Expression of the genes encoding Per2, Dbp, Arc, Egr1, Krox20 and NGFI-B was suppressed during inhalation of sevoflurane for 2 h and 6 h.
Negative_regulation (suppressed) of Gene_expression (Expression) of Egr1 associated with aids-related complex
11) Confidence 0.34 Published 2007 Journal Brain Res. Section Abstract Doc Link 17942082 Disease Relevance 0.10 Pain Relevance 0.70
The level of Egr-1 expression significantly decreased in the BoNT/E-treated cortex compared with that in the cortex of normal animals (average┬▒SEM: 43.5┬▒1.2%, p<0.05, unpaired t-test).
Negative_regulation (decreased) of Gene_expression (expression) of Egr-1 in cortex
12) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614467 Disease Relevance 0.07 Pain Relevance 0
We have previously described altered expression of Arc, CART, Egr1, Fos, NPY, and Nr4a1 in these samples in a directed study of genes with known relevance to drug abuse [12].
Negative_regulation (described) of Gene_expression (expression) of Egr1 associated with aids-related complex and drug abuse
13) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.29 Pain Relevance 0.38
We have previously described altered expression of Arc, CART, Egr1, Fos, NPY, and Nr4a1 in these samples in a directed study of genes with known relevance to drug abuse [12].
Negative_regulation (altered) of Gene_expression (expression) of Egr1 associated with aids-related complex and drug abuse
14) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.29 Pain Relevance 0.38
To describe a sympathetic afferent circuit, the left ureter was ligated in anesthetized rats for 1.5-2 h followed by immunocytochemical processing to localize expression of either the immediate early gene (IEG) c-fos or Krox-24 in the spinal cord or dorsal root ganglia (DRG).
Negative_regulation (localize) of in spinal cord Gene_expression (expression) of Krox-24 in left ureter associated with spinal cord
15) Confidence 0.28 Published 1996 Journal Brain Res. Section Abstract Doc Link 8813399 Disease Relevance 0 Pain Relevance 0.31
Striatal infusion of 6-cyano-7-nitroquinoxaline-2,3-dione (1 mM) completely blocked (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate-induced c-fos and zif268 expression.
Negative_regulation (blocked) of Gene_expression (expression) of zif268
16) Confidence 0.27 Published 1999 Journal Neuroscience Section Abstract Doc Link 10077330 Disease Relevance 0 Pain Relevance 0.90
However, an impairment of both ERK activation and Egr-1 biosynthesis by the MAP kinase kinase-1 (MEK-1) inhibitor PD98059 did not block cell death.
Negative_regulation (impairment) of Gene_expression (biosynthesis) of Egr-1 associated with death
17) Confidence 0.14 Published 2002 Journal Biochem. Pharmacol. Section Abstract Doc Link 11996893 Disease Relevance 0.51 Pain Relevance 0.36
Expression of inflammation-induced Zif268 was also attenuated after serotonin depletion, in parallel with mechanical sensitivity.
Negative_regulation (attenuated) of Gene_expression (Expression) of Zif268 associated with inflammation and serotonin
18) Confidence 0.14 Published 2008 Journal Mol Pain Section Body Doc Link PMC2553762 Disease Relevance 0.74 Pain Relevance 0.79
We determined whether curcumin, a natural product known to have anti-inflammatory properties, suppressed Egr-1 activation and concomitant expression of cytochemokines.
Spec (whether) Negative_regulation (suppressed) of Gene_expression (expression) of Egr-1 associated with inflammation
19) Confidence 0.12 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15569263 Disease Relevance 0.80 Pain Relevance 0.42

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